Brain Cognitive Network Abnormalities in Anemia Patients Using fNIRS

NCT07578675 | Recruiting

• 1 other identifier: QTJC2026037
• Study Type: observational
• Target: 323
• Locations: 1 country
• Sites: 1

Brief Summary

Anemia is a global public health concern and is closely linked to dysfunction of brain cognitive neural networks, a key mechanism underlying cognitive impairment. Such deficits-including declines in memory, learning, processing speed, and executive function-reduce daily living abilities and increase risks of falls and depression. Functional near-infrared spectroscopy (fNIRS) enables real-time monitoring of oxygenated and deoxygenated hemoglobin fluctuations, reflecting brain network function. This study aims to identify affected neural network regions in anemic patients and visualize connectivity changes using heatmaps and arc-based mapping. The findings will support early detection of cognitive impairment and guide precise clinical interventions, ultimately informing individualized treatment strategies to enhance therapeutic outcomes and quality of life.

Conditions

Aplastic Anemia; Myelodysplastic Syndromes; Autoimmune Hemolytic Anemia; Functional Near-Infrared Spectroscopy

Outcome Measures

Primary Outcomes (2)

• Concentration changes in oxygenated hemoglobin (HbO) and de-oxygenated hemoglobin (HbR)

  Functional Near Infrared Spectroscopy (fNIRS) is a non-invasive brain imaging modality, that can be used to measure HbO and HbR concentrations.

  Patients will be assessed within 48 hours of admission.

• Cognitive Function Assessment

  Montreal Cognitive Assessment (MoCA) is used to assess cognitive function in patients, with higher total scores indicating better cognitive function. The total score range is 0 to 30.

  Patients will be assessed within 48 hours of admission.

Secondary Outcomes (5)

• Anxiety symptoms

  Patients will be assessed within 48 hours of admission.

• Depression symptoms

  Patients will be assessed within 48 hours of admission.

• Sleep quality

  Patients will be assessed within 48 hours of admission.

• Physical fatigue

  Patients will be assessed within 48 hours of admission.

• Appetite condition

  Patients will be assessed within 48 hours of admission.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with anemia who were hospitalized for the first time during the period from 2026 to 2028.

You may qualify if:

• Diagnosis of anemia
• First hospitalization
• Male or female, aged 18-65 years
• Willing and able to comply with the requirements for this study and written informed consent

You may not qualify if:

• History of psychiatric illness
• History of severe brain disease

Sponsors & Collaborators

• Institute of Hematology & Blood Diseases Hospital, China: lead
• Tianjin University: collaborator

Study Sites (1)

Regenerative Medicine Center

Tianjin, Tianjin Municipality, China

RECRUITING

MeSH Terms

Conditions

Anemia, Aplastic; Myelodysplastic Syndromes; Anemia, Hemolytic, Autoimmune

Condition Hierarchy (Ancestors)

Anemia; Hematologic Diseases; Hemic and Lymphatic Diseases; Bone Marrow Failure Disorders; Bone Marrow Diseases; Anemia, Hemolytic; Autoimmune Diseases; Immune System Diseases

Central Study Contacts

ZheXiang Kuang, MSN

CONTACT

13920361752; kuangzhexiang@ihcams.ac.cn

Xiao Yu, Undergraduate

CONTACT

18722218448; yuxiao@ihcams.ac.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head Nurse

Study Record Dates

• First Submitted: May 5, 2026
• First Posted: May 11, 2026
• Study Start: October 11, 2025
• Primary Completion (Estimated): March 31, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: May 11, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)