Evaluation of the Effectiveness of Odontogenic Grafts Obtained From Human Teeth on Bone Formation

NCT07573761 | Enrolling By Invitation

• 1 other identifier: 24/4
• Study Type: observational
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

Tooth extraction triggers a cascade of biological events mediated by the local inflammatory response following surgical intervention and by the loss of masticatory stimulation to the periodontium. These factors disrupt the homeostasis and structural integrity of the periodontal tissues. Following tooth loss, bone remodeling is initiated and continues for several months, with the majority of dimensional and morphological changes occurring within the first three months. This early alveolar bone resorption may compromise future implant placement and prosthetic rehabilitation. Previous studies by Schmidt-Schultz and Schultz have demonstrated that biologically intact growth factors can be preserved within the collagenous extracellular matrix of ancient human bone and teeth. These findings suggest that stored dentin may retain biologically active growth factors and provide regenerative benefits comparable to those of freshly prepared dentin, while eliminating the need for simultaneous multiple surgical interventions. Moreover, the volume of particulate dentin exceeds twice the original root volume, allowing for the acquisition of sufficient graft material for clinical application. Based on these biological and volumetric advantages, the use of autogenous stored mineralized dentin grafts (ASMDG) has emerged as a promising approach for alveolar socket preservation. ASMDG may contribute to limiting post-extraction alveolar ridge resorption and maintaining ridge dimensions during the critical early healing period.

Conditions

Alveolar Bone Loss; Periodontal Diseases; Periodontal Bone Loss; Periodontal Atrophy; Bone Diseases; Bone Resorption

Outcome Measures

Primary Outcomes (1)

• Mean change in horizontal alveolar ridge width (mm) from baseline to 4 months (CBCT)

  Horizontal alveolar ridge width will be measured in millimeters using cone-beam computed tomography (CBCT) at baseline (immediately after tooth extraction) and at 4 months postoperatively prior to implant placement. The primary outcome will be defined as the mean change in ridge width (Δ width = width at 4 months - width at baseline), expressed in millimeters.

  Baseline (immediately after tooth extraction) and 4 months postoperatively (prior to implant placement)

Secondary Outcomes (1)

• Mean change in vertical alveolar ridge height (mm) from baseline to 4 months (CBCT)

  Baseline (immediately after tooth extraction) and 4 months postoperatively (prior to implant placement)

Study Arms (2)

Study Group

Dentin graft socket preservation

Control Group

Spontaneous healing

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult, systemically healthy patients indicated for the extraction of at least two posterior teeth with a hopeless prognosis due to periodontal disease, root caries, or root fractures, and who are candidates for implant-supported posterior rehabilitation. Eligible participants will present with intact alveolar socket walls after extraction, have no systemic or local contraindications affecting bone healing, and will provide written informed consent and comply with follow-up visits.

You may qualify if:

• Patients requiring tooth extraction due to periodontal reasons (teeth with a hopeless prognosis), root caries, or root fractures, who are simultaneously candidates for posterior replacement with an osseointegrated implant, and who require extraction of at least two teeth.
• Integrity of the alveolar socket walls following tooth extraction.
• Patients who accept the study conditions, sign written informed consent, and agree to attend the scheduled follow-up visits.

You may not qualify if:

• General contraindications for dental and/or surgical treatments.
• Inflammatory or autoimmune diseases of the oral cavity.
• Uncontrolled diabetes mellitus (HbA1c \> 7%).
• History of malignancy requiring chemotherapy or radiotherapy within the past 5 years.
• Previous treatment with immunosuppressive agents, bisphosphonates, or high-dose corticosteroids.
• Smoking more than 10 cigarettes per day.
• Pregnant or breastfeeding women.

Sponsors & Collaborators

• Istanbul Saglik Bilimleri University: lead

Study Sites (1)

Health Sciences University

Istanbul, Uskudar, 34668, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Alveolar Bone Loss; Periodontal Diseases; Periodontal Atrophy; Bone Diseases; Bone Resorption

Condition Hierarchy (Ancestors)

Musculoskeletal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: February 20, 2026
• First Posted: May 7, 2026
• Study Start: February 2, 2026
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: May 7, 2026

Record last verified: 2026-02

Locations

TU (1)