3D Printed Customized Bone Graft for Alveolar Regeneration: Longitudinal Cohort Evaluation

NCT07405918 | Not Yet Recruiting DMC

• 1 other identifier: Guaruhos University
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will evaluate the behavior of the implant-supported restorations (prosthesis) placed into the areas grafted with the 3D printed customized bone (personalized graft produced to fit a specific bone defect), as well as the volume contraction of the printed bone.

Conditions

Periodontal Diseases; Periodontal Bone Loss

Keywords

Personalized bone graft; 3D printed customized bone block; Guided Bone Regeneration; Personalized Medicine

Outcome Measures

Primary Outcomes (1)

• Periodontal Clinical Parameter of the implants Placed in the Grafted area

  Marginal Bone Loss \< 2mm

  5 years

Secondary Outcomes (1)

• Bone Graft Volume Alteration

  6 years

Interventions

Clinical evaluation OTHER

Clinical parmeters and radiographical analysis

Eligibility Criteria

• Age: 15 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This prospective cohort study will evaluate the peri-implant conditions of patients who received regenerative procedures using 3D-printed blocks at the UnG Clinic. To this end, participants will be selected from the UnG graduate clinic who received the regenerative treatment using 3D-printed blocks between 2019 and 2025. Participants selected for the study must sign the Informed Consent Form (ICF) after a verbal and written explanation of the project. Subjects will receive oral hygiene instruction and professional prophylaxis prior to clinical examinations.

You may qualify if:

• Systemically healthy individuals
• over 18 years of age
• Subjects that received regenerative surgical treatment by customized 3D printed blocks.
• Subjects must agree to participate in the study and agree to sign the Informed Consent.

You may not qualify if:

• Subjects with ilness that avoid their presence to the clinical evaluation
• ISubjects who have lost the customized blocks
• Subjects who do not agree to participate in the study will be excluded.

Sponsors & Collaborators

• University of Guarulhos: lead

MeSH Terms

Conditions

Periodontal Diseases; Alveolar Bone Loss

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Bone Resorption; Bone Diseases; Musculoskeletal Diseases; Periodontal Atrophy

Central Study Contacts

Jamil A Shibli, DDS, PhD

CONTACT

+55 11 982593439; jshibli@ung.br

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 21, 2026
• First Posted: February 12, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: April 28, 2026

Record last verified: 2026-04