A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
A Clinical Study to Compare Efficacy and Safety of Two Different Doses of CagriSema and Semaglutide in Participants With Obesity With or Without Type 2 Diabetes
3 other identifiers
interventional
2,500
18 countries
295
Brief Summary
This clinical study is testing how the study medicine CagriSema helps people living with obesity, with or without type 2 diabetes (T2D), lose weight. The purpose of the study is to find out how safe and effective CagriSema is for body weight loss in these participants. Participants will receive either CagriSema or semaglutide, and which treatment participants receive is decided by chance. CagriSema is a new study medicine being tested, while semaglutide is a medicine that doctors can already prescribe. The study will last for about 83 weeks
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 obesity
Started May 2026
295 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 27, 2026
CompletedFirst Posted
Study publicly available on registry
May 4, 2026
CompletedStudy Start
First participant enrolled
May 21, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 23, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
April 19, 2028
July 30, 2026
July 1, 2026
1.8 years
April 27, 2026
July 29, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Relative change in body weight
Measured as percentage (%).
From randomisation (week 0) to end of treatment (week 72)
Secondary Outcomes (25)
Relative change in body weight
From randomisation (week 0) to end of treatment (week 72)
Change in Body Mass Index (BMI)
From randomisation (week 0) to end of treatment (week 72)
Number of participants who achieve greater than or equal to (≥) 30% weight reduction
From randomisation (week 0) to end of treatment (week 72)
Number of participants who achieve ≥25% weight reduction
From randomisation (week 0) to end of treatment (week 72)
Number of participants who achieve greater ≥ 20% weight reduction
From randomisation (week 0) to end of treatment (week 72)
- +20 more secondary outcomes
Study Arms (3)
Cagrisema - dose level 1
EXPERIMENTALParticipants will receive CagriSema at dose level 1 once weekly subcutaneously during the treatment period for 72 weeks.
Cagrisema - dose level 2
ACTIVE COMPARATORParticipants will receive CagriSema at dose level 2 once weekly subcutaneously during the treatment period for 72 weeks.
Semaglutide
ACTIVE COMPARATORParticipants will receive Semaglutide once weekly subcutaneously during the treatment period for 72 weeks.
Interventions
Cagrisema (Cagrilintide and Semaglutide) will be administered subcutaneously.
Eligibility Criteria
You may qualify if:
- Male or female (sex assigned at birth, inclusive of all gender identities).
- Age 18 years or above at the time of signing the informed consent.
- BMI≥ 35.0 kg/m\^2.
- Participants without T2D: No history of T2D and HbA1c \< 6.5% (48 millimoles per mole (mmol/mol)) Participants with T2D: A history of T2D and HbA1c \< 10% (\< 86 mmol/mol). If a participant without a history of diabetes during the screening period receives an HbA1c result of 6.5% (48 mmol/mol) or higher, the investigator or the participant's healthcare provider must confirm the diagnosis of type 2 diabetes before the participant is randomised.
You may not qualify if:
- A self-reported change in body weight \> 5% within 90 days before screening, irrespective of medical records.
- Use of any glucagon-like-peptide-1 receptor agonist (GLP-1 RA), including medication with GLP-1 RA activity, or amylin analogues, including medication with amylin activity, within 6 months before screening.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Novo Nordisk A/Slead
Study Sites (303)
Uni of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
Cahaba Research
Pelham, Alabama, 35124, United States
Elligo Health Research Inc
Gilbert, Arizona, 85296, United States
Velocity Clinical Research-Phoenix
Phoenix, Arizona, 85006, United States
Arkansas Clinical Research
Little Rock, Arkansas, 72205, United States
Woodland Int. Research Group
Little Rock, Arkansas, 72211, United States
Headlands Research California, LLC
Escondido, California, 92025, United States
Neighborhood Healthcare
Escondido, California, 92025, United States
Diabetes & Endocrine Specialists - La Mesa
La Mesa, California, 91942, United States
Clinical Trials Research_Sacramento
Lincoln, California, 95648, United States
Loma Linda University Faculty Medical Clinics
Loma Linda, California, 92354, United States
Pacific Clinical Studies
Los Alamitos, California, 90720, United States
Valley Clinical Trials
Northridge, California, 91325, United States
Desert Oasis Healthcare
Palm Springs, California, 92262, United States
Linda Vista Health Care Ctr
San Diego, California, 92111, United States
Velocity Clin Res - Van Nuys
Van Nuys, California, 91405, United States
Flourish Research - CA
Walnut Creek, California, 94598, United States
University of Colorado Hospital
Aurora, Colorado, 80045, United States
TBMR & Alcanza
Clearwater, Florida, 33761, United States
Northeast Research Institute
Fleming Island, Florida, 32003, United States
Northeast Research Institute
Jacksonville, Florida, 32204, United States
Westside Center For Clinical Research
Jacksonville, Florida, 32205, United States
Bioclinical Research Alliance
Miami, Florida, 33155, United States
New Horizon Research Center
Miami, Florida, 33165, United States
South Broward Research LLC
Miramar, Florida, 33027, United States
West Orange Endocrinology
Ocoee, Florida, 34761, United States
Oviedo Medical Research, LLC
Oviedo, Florida, 32765, United States
Clinical Trial Services Corp
Pembroke Pines, Florida, 33024, United States
Hope Clin Res & Wellness
Conyers, Georgia, 30094, United States
Center for Adv Res & Education
Gainesville, Georgia, 30501, United States
Endocrine Research Solutions, Inc
Roswell, Georgia, 30076, United States
North Georgia Clinical Research
Woodstock, Georgia, 30189-4255, United States
Solaris Clinical Research
Meridian, Idaho, 83646, United States
Cedar-Crosse Research Center
Chicago, Illinois, 60607, United States
Macoupin Fam Practice Ctr, LLP
Gillespie, Illinois, 62033, United States
Clinical Investigation Spec Gurnee
Gurnee, Illinois, 60031, United States
Endeavor Health
Skokie, Illinois, 60077, United States
Evanston Premier Hlthcr Res
Skokie, Illinois, 60077, United States
Iowa Diabetes Research
West Des Moines, Iowa, 50266, United States
Alliance for Multispecialty Research
Newton, Kansas, 67114, United States
Cotton O'Neil Diab & Endo Ctr
Topeka, Kansas, 66606, United States
The Research Group of Lexington LLC
Lexington, Kentucky, 40503, United States
Endo and Metabolic Consultants
Rockville, Maryland, 20852, United States
Northern Pines Hlth Ctr, PC
Buckley, Michigan, 49620, United States
International Diabetes Center
Minneapolis, Minnesota, 55416, United States
AES Minneapolis DRS
Richfield, Minnesota, 55423, United States
Belzoni Clinical Research
Belzoni, Mississippi, 39038, United States
Clinical Research Professionals
Chesterfield, Missouri, 63005, United States
Amicis Centers of Clinical Research
St Louis, Missouri, 63128, United States
Southgate Medical Group, LLP
West Seneca, New York, 14224, United States
PharmQuest Life Sciences LLC
Greensboro, North Carolina, 27408, United States
Physician's East Endocrinology
Greenville, North Carolina, 27834, United States
Carteret Medical Group
Morehead City, North Carolina, 28557, United States
Centricity Rsrch MHCity Multi
Morehead City, North Carolina, 28557, United States
Piedmont Healthcare/Research
Statesville, North Carolina, 28625, United States
Accellacare Wilmington
Wilmington, North Carolina, 28401, United States
Lillestol Research LLC
Fargo, North Dakota, 58104, United States
Plains Clinical Research Center, LLC
Fargo, North Dakota, 58104, United States
Advanced Medical Research
Maumee, Ohio, 43537, United States
Alliance for Multispecialty Research
Norman, Oklahoma, 73069, United States
Lynn Institute of Norman
Norman, Oklahoma, 73072, United States
Heritage Valley Medical Group
Beaver, Pennsylvania, 15009, United States
Hatboro Med Associates
Hatboro, Pennsylvania, 19040, United States
Northeast Endocrine Metabolic Associates
Philadelphia, Pennsylvania, 19114, United States
Clinical Res Collaborative
Cumberland, Rhode Island, 02864, United States
Velocity Clinical Research-Gaffney
Gaffney, South Carolina, 29340, United States
Spartanburg Medical Research
Spartanburg, South Carolina, 29303, United States
Jackson Clinic
Jackson, Tennessee, 38305, United States
Holston Medical Group
Kingsport, Tennessee, 37660, United States
CNS Healthcare
Memphis, Tennessee, 38119, United States
HealthStar Physicians, PC
Morristown, Tennessee, 37813, United States
Clinical Research Associates
Nashville, Tennessee, 37203, United States
Amarillo Med Spec LLP
Amarillo, Texas, 79124, United States
Texas Diab & Endo, P.A.
Austin, Texas, 78731, United States
Velocity Clinical Research Austin
Austin, Texas, 78759, United States
Velocity Clin Res, Dallas
Dallas, Texas, 75230, United States
North Texas Endocrine Center
Dallas, Texas, 75231, United States
Cedar Health Research
Euless, Texas, 76040, United States
JCCT- Juno NW Houston
Houston, Texas, 77040, United States
The Endocrine Center
Houston, Texas, 77079, United States
Medical Colleagues-Texas LLP
Katy, Texas, 77450, United States
Sante Clinical Research
Kerrville, Texas, 78028, United States
Radiance Clinical Research
Lampasas, Texas, 76550, United States
Aeres Clinical Research
Laredo, Texas, 78041, United States
DCOL Ctr for Clin Res
Longview, Texas, 75605, United States
RGV Endocrine Center
McAllen, Texas, 78503, United States
Quality Research Inc
San Antonio, Texas, 78209, United States
AES San Antonio
San Antonio, Texas, 78229, United States
Northeast Clinical Research of San Antonio
San Antonio, Texas, 78233, United States
Consano Clinical Research, LLC
Shavano Park, Texas, 78231, United States
Mt Olympus Medical Research, LLC
Sugar Land, Texas, 77478, United States
J.Lewis Research Inc
Salt Lake City, Utah, 84109, United States
J.Lewis Research Inc
Salt Lake City, Utah, 84121, United States
Diabetes & Endo Tx Specialists
Sandy City, Utah, 84093, United States
J.Lewis Research Inc
South Jordan, Utah, 84095, United States
Health Res of Hampton Roads
Newport News, Virginia, 23606, United States
Tidewater Physicians Multispecialty Group
Newport News, Virginia, 23606, United States
National Clin Res Inc.
Richmond, Virginia, 23294, United States
Prevea Health
Green Bay, Wisconsin, 54303, United States
CEMEDIC
CABA, Buenos Aires, C1440CFD, Argentina
Centro de Investigaciones Metabólicas
Capital Federal, Buenos Aires, C1056ABI, Argentina
CICEMO- Consultorio (Av Directorio)
Ciudad Autónoma de Buenos Aires, Buenos Aires, C1424CIQ, Argentina
Centro Médico Arsema
Ciudad Autónoma de Buenos Aires, Buenos Aires, C1427, Argentina
Centro de Investigación C.I.C.E 9 de Julio - Sanatorio 9 de Julio
San Miguel de Tucumán, Tucumán Province, T4000DPX, Argentina
OMI- Organización Médica de Investigación
Buenos Aires, C1015, Argentina
Kynet Recoleta
Buenos Aires, C1119ACU, Argentina
Hospital Sirio Libanes
Buenos Aires, C1419, Argentina
Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli
Buenos Aires, C1425AGC, Argentina
CEDIC Centro de Investigación Clínica
CABA, C1060ABA, Argentina
CIPREC Arenales
CABA, C1061AAS., Argentina
Centro Médico Viamonte SRL
CABA, C1120AAC, Argentina
Instituto Centenario
Ciudad de Buenos Aires, C1204AAD, Argentina
CEDIR - Centro de diagnóstico y rehabilitación Santa Fe
Santa Fe, S3000FSO, Argentina
Sanatorio Norte
Santiago del Estero, G4200, Argentina
Sydney Clinical Trials
Campbelltown, New South Wales, 2560, Australia
Gosford Renal Research
Gosford, New South Wales, 2250, Australia
Sydney Cardiometabolic Centre
Liverpool, New South Wales, 2170, Australia
Hunter Diabetes Centre
Merewether, New South Wales, 2291, Australia
University of Sunshine Coast - Vitality Village
Birtinya, Queensland, 4575, Australia
University of Sunshine Coast - South Brisbane
South Brisbane, Queensland, 4101, Australia
Emeritus Research Melbourne
Camberwell, Victoria, 3124, Australia
Medical University of Graz
Graz, 8036, Austria
Ordination Winhofer-Stöckl
Mattersburg, 7210, Austria
Fließer-Görzer [Ordination]
Saint Stefan, 8511, Austria
Klinik Landstraße
Vienna, 1030, Austria
Universitätsklinikum AKH Wien
Vienna, 1090, Austria
Ordination Dr. Günter Sokol
Vienna, 1120, Austria
Klinik Hietzing 3. Med. Abt.
Vienna, 1130, Austria
Itariu [Ordination]
Vienna, 1180, Austria
Anima Research Center
Alken, 3570, Belgium
Cliniques universitaires Saint-Luc
Brussels, 1200, Belgium
KORMONT
Kluisbergen, 9690, Belgium
CHU Tivoli
La Louvière, 7100, Belgium
MECLINAS
Mechelen, 2800, Belgium
AZ Delta - Roeselare
Roeselare, 8800, Belgium
KORMONT
Zwalm, 9630, Belgium
MC For Life EOOD
Burgas, 8000, Bulgaria
MC Kazanlak EOOD
Kazanlak, 6100, Bulgaria
Medical center Medi City 21 OOD
Kyustendil, 2500, Bulgaria
OCSOMCE - Dr. Albena Dinkova EOOD
Pleven, 5800, Bulgaria
AIPSMCEMDID - Dr. Georgi Levterov EOOD
Plovdiv, 4000, Bulgaria
DCC Sveti Georgi EOOD
Plovdiv, 4002, Bulgaria
Hipocrat 9 - Dr. Rumyana Boykova - Draganova - AISPEMD EOOD
Sofia, 1463, Bulgaria
DCC XX - Sofia EOOD, Endocrinology
Sofia, 1618, Bulgaria
MC Diamedical - 2013 OOD, Sofia
Sofia, 1618, Bulgaria
Medical Centre Medical Arts Medico-dental centre
Sofia, 1618, Bulgaria
DCC XXV Sofia EOOD, Endocrinology Consulting room
Sofia, 1712, Bulgaria
UMHAT Prof. Dr. Stoyan Kirkovich AD
Stara Zagora, 6003, Bulgaria
AIPSMC Dr. Evelina Zlatanova EOOD
Varna, 9010, Bulgaria
MC Nevromedics EOOD, Internal Diseases
Veliko Tarnovo, 5005, Bulgaria
C-Health Partners
Calgary, Alberta, T2V 4J2, Canada
Kelowna Health and Memory Centre Ltd.
Kelowna, British Columbia, V1Y 5A8, Canada
Medical Arts Health Research Group_Kelowna
Kelowna, British Columbia, V1Y4N7, Canada
Ocean West Research Clinic
Surrey, British Columbia, V3Z 2N6, Canada
Hilltop Medical Clinic
Surrey, British Columbia, V4A 0C1, Canada
Dr. M.B. Jones Inc
Victoria, British Columbia, V8V 4A1, Canada
G.A. Research Associates Ltd.
Moncton, New Brunswick, E1G 1A7, Canada
Nova Scotia Hlth Halifax
Halifax, Nova Scotia, B3H1V7, Canada
Care Access Cape Breton
Sydney, Nova Scotia, B1M 0A1, Canada
Centricity Research Brampton Endocrinology
Brampton, Ontario, L6S 0C6, Canada
Apex Trials
Guelph, Ontario, N1G 0B4, Canada
Hamilton Medical Research Group
Hamilton, Ontario, L8L 5G4, Canada
Premier Clinical Trial Research Network (PCTRN)
Hamilton, Ontario, L8L 5G4, Canada
Wharton Medical Clinic Clinical Trials (Hamilton)
Hamilton, Ontario, L8L 5G8, Canada
Milestone Research
London, Ontario, N5W 6A2, Canada
Bluewater Clin Res Group Inc
Sarnia, Ontario, N7T 4X3, Canada
Diabetes Heart Research Centre
Toronto, Ontario, M6G 1M2, Canada
Centre Medical Acadie
Montreal, Quebec, H4N 2W2, Canada
Centricity Res Pointe-Claire
Pointe-Claire, Quebec, H9R 4S3, Canada
Diex Recherche Quebec
Québec, G1V 4T3, Canada
Alpha Recherche Clinique - Lebourgneuf
Québec, G2J 0C4, Canada
Fakultní nemocnice U sv. Anny v Brně
Brno, 656 91, Czechia
Centrum zdraví Dolní Břežany, a.s.
Dolní Břežany, 252 41, Czechia
KARDIOLOGIE - LIBEREC s.r.o.
Liberec, 460 01, Czechia
Interní a diabetologická ordinace s.r.o.
Náchod, 54701, Czechia
DIALINE s.r.o.
Plzeň 3, 301 00, Czechia
ENDOTRIAL s.r.o.
Prague, 10400, Czechia
Milan Kvapil s.r.o.
Prague, 149 00, Czechia
EUC Klinika Praha a.s.
Prague, 150 00, Czechia
Fledip s.r.o.
Prague, 160 00, Czechia
CHU ROUEN_HOPITAL DE BOIS GUILLAUME_Service de Nutrition
Bois-Guillaume, 76230, France
CENTRE HOSPITALIER DE COLMAR_Endocrinologie/Diabetologie/Centre Nutritionnel
Colmar, 68024, France
LES HOPITAUX DE CHARTRES_HOPITAL LOUIS PASTEUR_Service d'endocrinologie
Le Coudray, 28630, France
APHP - LA PITIE SALPETRIERE _ Service de Nutrition
Paris, 75013, France
HOPITAL EUROPEEN GEORGES POMPIDOU_Service de nutrition et diabétologie
Paris, 75015, France
CHU DE BORDEAUX-HOPITAL HAUT LEVEQUE_Service d'Endocrinologie, Diabétologie et Maladies Métaboliques
Pessac, 33600, France
HCL-HOPITAL LYON SUD_Service d'Endocrinologie-Diabète-Nutrition
Pierre-Bénite, 69310, France
CHU NANTES - HOPITAL NORD LAENNEC_Service d'Endocrinologie-Diabétologie-Nutrition
Saint-Herblain, 44800, France
CENTRE DE RECHERCHE CLINIQUE PORTES DU SUD_Service d'Endocrinologie-Diabétologie-Maladies Métaboliques
Vénissieux, 69200, France
University General Hospital Of Alexandroupoli - First Department of Internal Medicine
Alexandroupoli, 68100, Greece
Evangelismos S.A. - Endocrinology department
Athens, 10676, Greece
Laiko General Hospital Of Athens - 1st department of Internal Medicine
Athens, 115 27, Greece
Athens Medical Center S.A. (Iatriko Psychikou) - Department of Internal Medicine & Metabolic Diseases
Athens, 11525, Greece
General Hospital Of Athens Alexandra - Clinical Therapeutics
Athens, 11528, Greece
General Hospital Of Lamia - Internal Medicine Clinic
Lamia, 35100, Greece
Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit
Marousi, 15125, Greece
Athens Medical Center S.A. (Iatriko P. Falirou) - Diabetes and Clinical Research Center
Palaió Fáliro, 17562, Greece
Athens Medical Center S.A. (Iatriko Peristeriou) - Diabetes, obesity and cardiometabolic diseases department
Peristeri, 121 31, Greece
Athens Medical Center S.A., European Interbalkan Medical Center - Department of Internal Medicine
Thessaloniki, 546 39, Greece
General Hospital Of Thessaloniki G Gennimatas - Internal Medicine Clinic
Thessaloniki, 54635, Greece
NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes
Thessaloniki, 54635, Greece
Thermi Clinic S.A. - Diabetes and Internal Medicine Department
Thessaloniki, 57001, Greece
Dr. Lakatos Ferenc Kardiológus ,Belgyógyász Magán szakrendelés
Békéscsaba, Bekes County, 5600, Hungary
Lausmed Kft.
Baja, Bács-Kiskun county, 6500, Hungary
Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ
Szeged, Csongrád-Csanád, 6725, Hungary
Óbudai Egészségügyi Centrum
Budapest, Pest County, 1036, Hungary
Szatmári-Med Kft.
Budapest, Pest County, 1213, Hungary
Medifarma-98 Kft.
Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary
EURÉKA-CENTER Orvosi és Szolgáltató Betéti Társaság
Baja, 6500, Hungary
Békés Vármegyei Központi Kórház
Békéscsaba, 5600, Hungary
Trial Pharma Kft.
Békéscsaba, 5600, Hungary
Biatros Kft.
Biatorbágy, 2051, Hungary
Semmelweis Egyetem
Budapest, 1083, Hungary
Cardiogeneral Kft.
Budapest, H-1141, Hungary
Mentaház Kft.
Székesfehérvár, 8000, Hungary
Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház-Rendelőintézet
Szolnok, 5000, Hungary
AOU IRCCS Policlinico di Sant'Orsola Malpighi - UOC Endocrinologia e Prevenzione e Cura del Diabete
Bologna, Emilia-Romagna, 40138, Italy
IRCCS Ospedale Policlinico San Martino - U.O.D. Dietetica e Nutrizione Clinica
Genoa, Liguria, 16132, Italy
Spedali Civili Brescia - SSD Endocrinologia
Brescia, Lombardy, 25123, Italy
Ospedale San Raffaele S.r.l. - Unità di Cardio-metabolismo e Trials Clinici
Milan, Lombardy, 20132, Italy
Azienda Ospedaliera di Perugia;Ospedale S. Maria della Misericordia
Perugia, Pg, 06129, Italy
D.A.I. Oncologico - U.O.C. di Chirurgia Generale ad indirizzo Oncologico
Messina, Sicily, 98124, Italy
INRCA Ancona - UOC Clinica Medica e Geriatrica
Ancorna, The Marches, 60127, Italy
Azienda Ospedaliero Universitaria Pisana
Pisa, Tuscany, 56126, Italy
Azienda Ospedaliero-Universitaria Renato Dulbecco
Catanzaro, 88100, Italy
PreCare Trial & Recruitment
Born, Limburg, 6121 XK, Netherlands
Progress Clinical Research Den Bosch
's-Hertogenbosch, North Brabant, 5223 LA, Netherlands
Rijnstate Ziekenhuis
Arnhem, 6815 AD, Netherlands
Catharina Zkh Eindhoven - Interne geneeskunde
Eindhoven, 5623 EJ, Netherlands
Spaarne Gasthuis Hoofddorp - Interne
Hoofddorp, 2134 TM, Netherlands
Bethesda Diabetes Research Center
Hoogeveen, 7909 AA, Netherlands
Ikazia Ziekenhuis
Rotterdam, 3083 AN, Netherlands
Medisch Centrum Thomsonplein
The Hague, 2565 KV, Netherlands
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, 15-276, Poland
Gabinet Leczenia Otylosci i Chorob Dietozaleznych
Bialystok, 15-281, Poland
Kresmed Sp. z o. o.
Bialystok, 15-481, Poland
Renew Clinic Sp. z o.o.
Bialystok, 15-797, Poland
Gierach-Med
Bygdoszcz, 85-796, Poland
ETG Lublin Sp. z o.o.
Dębica, 39-200, Poland
Pro Familia Altera Sp. z o.o.
Katowice, 40-648, Poland
Vita Longa Sp. z o. o.
Katowice, 40-748, Poland
Małopolskie Centrum Kliniczne
Krakow, 30-149, Poland
Maciej Wiza Gaja Poradnie Lekarskie
Poznan, 61-251, Poland
Centrum Medyczne Medyk Sp.zo.o. Sp.k.
Rzeszów, 35-055, Poland
Gyncentrum Sp. z o. o.
Warsaw, 00-124, Poland
Medon Clinical Research Sp. z o.o.
Warsaw, 02-679, Poland
Wojewódzki Szpital Specjalistyczny im. J. Gromkowskiego
Wroclaw, 51-149, Poland
Centrum Medyczne Oporow
Wroclaw, 52-416, Poland
ULS Almada-Seixal E.P.E. - HGO_Serviço de Endocrinologia
Almada, 2805-267, Portugal
ULS Do Oeste E.P.E. - Unidade Caldas da Rainha_CAMI - Unidade de Diabetes
Caldas da Rainha, 2500-176, Portugal
ULS Do Baixo Mondego, E.P.E. - HDFF_Serviço Cardiologia
Figueira da Foz Municipality, 3094-001, Portugal
Hospital da Luz Lisboa, S.A._Serviço de Medicina Interna
Lisbon, 1500-650, Portugal
ULS De Matosinhos, E.P.E - HPH_Serviço de Endocrinologia
Senhora Da Hora, Matosinhos, 4464-513, Portugal
Ucardio Centro Clinico Unidade Cardiovascular
Torres Novas, 2350-111, Portugal
Hospital Trofa Saude Senhor do Bonfim S.A_Unidade de Ensaios Clínicos
Vila do Conde, 4480-565, Portugal
Hospital da Luz Arrábida, S.A_Serviço de Endocrinologia
Vila Nova de Gaia, 4400-346, Portugal
Grandmed SRL
Oradea, Bihor County, 410159, Romania
S.C. Top Diabet Srl
Craiova, Dolj, 200515, Romania
CMI Dr Pop Lavinia
Baia Mare, Maramureş, 430222, Romania
Sc Mediab Srl
Târgu Mureş, Mureș County, 540142, Romania
Mariodiab Clinic SRL
Brasov, 500101, Romania
Sc Nicodiab Srl
Bucharest, 010507, Romania
Mat Cord Biomedica S.R.L.
Buzău, 120133, Romania
Spitalul Clinic Judetean De Urgenta Bihor
Oradea, 410469, Romania
Sc Sal Med Srl
Piteşti, 110424, Romania
Cabinet Medical Dr Geru SRL
Timișoara, 300288, Romania
Spitalul Clinic Judetean De Urgenta Pius Brinzeu Timisoara
Timișoara, 300723, Romania
DIA - CLARUS s.r.o.
Bojnice, 97201, Slovakia
KARDIO-SANUS, spol. s r.o.
Bratislava, 84108, Slovakia
MEDISPEKTRUM s.r.o.
Bratislava, 851 01, Slovakia
Diab - Int, s.r.o.
Bytča, 014 01, Slovakia
HUMAN-CARE, s.r.o.
Košice, 040 01, Slovakia
ENDOMED, s.r.o.
Košice, 04013, Slovakia
DIAMARTIN, s. r. o.
Martin, 036 01, Slovakia
LUDIA, s. r. o.
Spišská Nová Ves, 05201, Slovakia
Phoenix Pharma
Port Elizabeth, Eastern Cape, 6001, South Africa
IATROS International
Bloemfontein, Free State, 9301, South Africa
Medi-Clinic Bloemfontein
Bloemfontein, Free State, 9301, South Africa
Soweto Clinical Trial Centre
Johannesburg, Gauteng, 1818, South Africa
Hemant Makan
Johannesburg, Gauteng, 1827, South Africa
Newtown Clinical Research
Johannesburg, Gauteng, 2001, South Africa
Wits Bara Clinical Trial Site
Johannesburg, Gauteng, 2013, South Africa
Sandton Medical Research
Johannesburg, Gauteng, 2196, South Africa
Lenasia Clinical Trial Centre
Lenasia, Gauteng, 1827, South Africa
Clinical Trial Systems (CTC)
Pretoria, Gauteng, 0186, South Africa
Dr Pillay's Rooms
Durban, KwaZulu-Natal, 4450, South Africa
Tread Research (Pty)Ltd
Cape Town, Western Cape, 7500, South Africa
Dr Hendrik Snyman's Practice
Mossel Bay, Western Cape, 6500, South Africa
Paarl Research Centre
Paarl, Cape Town, Western Cape, 7646, South Africa
Clinical Trials Network Helderberg (Pty) Ltd
Somerset West, Western Cape, 7130, South Africa
Complejo Hospitalario Universitario A Coruña
A Coruña, 15006, Spain
Hospital Comarcal de Antequera
Antequera, 29200, Spain
CAPSBE_CAP Ernest LLuch
Barcelona, 08028, Spain
Hospital Vall d'Hebron
Barcelona, 08035, Spain
Eap Osona Sud Alt Congost S.L.P
Centelles (Barcelona), 08540, Spain
Clínica Bofill
Girona, 17002, Spain
Hosp. Univ. Ruber Juan Bravo_Endocrinología
Madrid, 28006, Spain
Hospital Universitario de la Princesa
Madrid, 28006, Spain
Hospital Universitario Sanitas Virgen del Mar
Madrid, 28016, Spain
Hospital Universitario de Fuenlabrada
Madrid, 28942, Spain
Althaia Xarxa Assistencial Universitaria De Manresa Fundacio Privada
Manresa, 08243, Spain
H. Clinico Univ. Virgen de la Victoria
Málaga, 29010, Spain
Hosp. Recoletas Salud Campo Grande_Endoc y Nutric
Valladolid, 47004, Spain
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Clinical Transparency (dept. 2834)
Novo Nordisk A/S
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Masking Details
- Sponsor staff involved in the clinical trial is masked according to company standard procedures.
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 27, 2026
First Posted
May 4, 2026
Study Start
May 21, 2026
Primary Completion (Estimated)
February 23, 2028
Study Completion (Estimated)
April 19, 2028
Last Updated
July 30, 2026
Record last verified: 2026-07
Data Sharing
- IPD Sharing
- Will share
According to the Novo Nordisk disclosure commitment on novonordisk-trials.com