Role of Echocardiography and Ultrasound Indices in Resuscitation of Septic Shock Patients

NCT07550400 | Recruiting DMC

• 1 other identifier: FMASU MD 240L2025
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Fluid replacement is considered the cornerstone of hemodynamic management in critically ill patients especially in patients with septic shock. However, only about 50% of critically ill hemodynamically unstable patients are responsive to fluids. Consequently, the resuscitation of critically ill patients requires an accurate assessment of the patients' intravascular volume status and their volume responsiveness. In this study, we will compare the efficacy of carotid artery flow to echo left ventricular end diastolic volume as a predictive value for fluid resuscitation in septic shock patients.

Conditions

Septic Shock; Fluid Resuscitation

Keywords

End diastolic diameter; carotid artery duplex; septic shock

Outcome Measures

Primary Outcomes (1)

• Accuracy of echo and ultrasound indices

  Diagnostic accuracy (sensitivity, specificity) of LVEDA and carotid artery flow parameters (PEAK Systolic Velocity, Velocity time integral (VTI), in predicting fluid responsiveness defined as an increase in stroke volume after a standardized fluid challenge.

  1 Day

Study Arms (1)

septic shock patients

septic shock according to SOFA score more than or equal 1

Procedure: carotid artery duplex; Procedure: Left ventricular end diastolic area

Interventions

carotid artery duplex PROCEDURE

, Carotid Doppler (T0) will be performed within 1-2 Hours of ICU Admission to measure the following parameters: "Peak systolic velocity" and Velocity Time Integral over the common carotid artery. Using the linear probe (VF12-4) of ultrasound machine (ACUSON NX3, Siemens Medical solution USA, Inc.) * According to surviving sepsis campaign guidelines 2021, patients diagnosed with septic shock should be given 30ml/kg IV crystalloid fluid within the first 3 hours, the fluid will be given in the form of 500 ml boluses, each bolus should be given in 15 minutes. * FC "fluid challenge" will be performed by rapid volume infusion over (30minutes) of 1000mL Ringer acetate solution. * Carotid artery Duplex parameters will be repeated. Relative changes in "Peak Systolic Velocity, Velocity Time integral" will be expressed in

septic shock patients

Left ventricular end diastolic area PROCEDURE

* Echocardiography (T0) will be performed within 1-2 Hours of ICU Admission to measure LVEDA if less than 10 cm2 then the patient will be considered hypovolemic. * According to surviving sepsis campaign guidelines 2021, patients diagnosed with septic shock should be given 30ml/kg IV crystalloid fluid within the first 3 hours, the fluid will be given in the form of 500 ml boluses, each bolus should be given in 15 minutes. * FC "fluid challenge" will be performed by rapid volume infusion over (30minutes) of 1000mL Ringer acetate solution. * After five minutes from FC "fluid challenge" (T1), echocardiography will be repeated to re-measure LVEDA. Pt will be defined as a responder if LVEDA b

septic shock patients

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

septic shock patients in ICU

You may qualify if:

• ▪ Age:18-50 years old
• Sex: both males \&females.
• Patients diagnosed with septic shock according to SOFA score more than or equal 1
• Presence of at least one sign of acute circulatory failure from:
• Low blood pressure (mean arterial pressure \<65 mmHg and / or systolic \<90 mmHg).
• Tachycardia\> 120 bpm without other obvious cause of circulatory failure.
• Oliguria \<1 ml / kg during the last hour suggestive of circulatory failure.
• Blood hyperlactatemia \> 2mmol / l without other obvious cause a systemic circulatory failure.
• Another sign justifying, for example vascular increase capillary refill time more than 2 seconds.

You may not qualify if:

• ▪ Known significant valvular heart disease (sever aortic insufficiency or stenosis)
• Known carotid artery stenosis \>50% or previous carotid surgery
• Clear contraindication to the carotid artery Doppler such as wound or infection or complete or partial occlusion of the carotid artery.
• Arrhythmias affect stroke volume assessment (atrial fibrillation, frequent PVCs)
• Dilated cardiomyopathy.
• Poor transthoracic echocardiographic window
• Patient refusal

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Faculty of medicine, Ain Shams University

Cairo, Egypt

RECRUITING

MeSH Terms

Conditions

Shock, Septic

Condition Hierarchy (Ancestors)

Sepsis; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Central Study Contacts

baheya kamel

CONTACT

+2-01115746487; baheya.hesham.kamel@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 18, 2026
• First Posted: April 24, 2026
• Study Start: May 3, 2026
• Primary Completion (Estimated): November 2, 2026
• Study Completion (Estimated): November 12, 2026
• Last Updated: April 24, 2026

Record last verified: 2025-09

Locations

EG (1)