Assessment of Cardiac Output and Stroke Volume in Septic Shock Patients

NCT07321405 | Not Yet Recruiting

• 1 other identifier: COP and SV in septic shock
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this research is to compare the accuracy and reliability of electrical cardiometry versus transthoracic echocardiography in measuring cardiac output and stroke volume in patients with septic shock, to evaluate the potential of EC as a non-invasive alternative for hemodynamic monitoring.

Conditions

Septic Shock

Outcome Measures

Primary Outcomes (3)

• to compare the accuracy and reliability of electrical cardiometry versus transthoracic echocardiography in measuring cardiac output in patients with septic shock.

  to compare the accuracy and reliability of electrical cardiometry versus transthoracic echocardiography in measuring cardiac output in patients with septic shock.

  2026-2028

• cardiac output and stroke volume in septic shock patients

  comparison between accuracy and reliability in assessment of cardiac out put and stroke volume using echocardiogram vs electrical cardiometer

  baseline

• to compare the accuracy and reliability of electrical cardiometry versus transthoracic echocardiography in measuring stroke volume in patients with septic shock.

  to compare the accuracy and reliability of electrical cardiometry versus transthoracic echocardiography in measuring stroke volume in patients with septic shock.

  2026-2028

Study Arms (1)

septic shock patients

echocardiography and electrical cardiometry will be applied to these patients

Device: echocardiogram; Device: Electrical cardiometry

Interventions

Electrical cardiometry DEVICE

Electrical cardiometry (EC) is an emerging non-invasive bio-impedance technique offering continuous monitoring with easier application and less operator dependency. Despite its advantages, EC's accuracy and reliability in critically ill septic patients require further validation.

septic shock patients

echocardiogram DEVICE

Transthoracic echocardiography (TTE) is the gold standard for non-invasive bedside assessment of CO and SV, providing precise evaluation of cardiac structure and flow. However, TTE requires operator expertise, can be time-consuming, and may be limited by patient-specific factors.

septic shock patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients were aged more than 18 years diagnosed with septic shock following the surviving sepsis campaign \-

You may not qualify if:

• patients aged less than 18 years pregnant women cases suffering cardiac diseases (heart failure, arrhythmia, moderate, and severe valvular disease) patients with poor quality echocardiographic images and measurements

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University Hospital

Asyut, 71511, Egypt

Location

Related Publications (1)

• Song W, Guo J, Cao D, Jiang J, Yang T, Ma X, Yuan H, Wu J, Guan X, Si X. Comparison of noninvasive electrical cardiometry and transpulmonary thermodilution for cardiac output measurement in critically ill patients: a prospective observational study. BMC Anesthesiol. 2025 Mar 13;25(1):123. doi: 10.1186/s12871-025-03005-1.

  PMID: 40082773 BACKGROUND

Related Links

• https://pubmed.ncbi.nlm.nih.gov/40082773/

MeSH Terms

Conditions

Shock, Septic

Interventions

Echocardiography

Condition Hierarchy (Ancestors)

Sepsis; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular

Study Officials

• ahmed obeid allah, professor

  Assiut University

  STUDY DIRECTOR

• alaa abd elbadee, lecturer

  Assiut University

  STUDY CHAIR

• mostafa hosney, lecturer

  Assiut University

  STUDY CHAIR

Central Study Contacts

Osman khalaf, bachelor

CONTACT

01098360564; om62326232@gmail.com

osman khalaf, resident

CONTACT

01098360564

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident physician

Study Record Dates

• First Submitted: November 24, 2025
• First Posted: January 7, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): July 1, 2027
• Study Completion (Estimated): December 10, 2027
• Last Updated: January 7, 2026

Record last verified: 2025-12

Locations

EG (1)