Effects of 7-Day Creatine Supplementation on Cognitive Function After High-Intensity Interval Training in Active Young Men

NCT07534293 | Completed

• 2 other identifiers: 12.02.01/UN32.14.2.8/LT20324309/B3/DT.03.08/2025
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates whether 7-day creatine monohydrate supplementation affects cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were assigned to one of four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, or creatine 0.3 g/KgBW/day plus exercise. Cognitive performance was measured before and after the intervention using visual reaction time, go/no-go visual reaction time, and Trail Making Tests A and B.

Conditions

Creatine Supplementation; Exercise Ergogenics

Keywords

creatine monohydrate; High Intensity Interval Training; Cognitive; Reaction Time; Executive Function

Outcome Measures

Primary Outcomes (1)

• Go/No-Go Visual Reaction Time False Alarm Errors

  Number of false alarm (commission) errors recorded during the Go/No-Go Visual Reaction Time test. Lower values indicate better inhibitory control.

  Baseline and Day 7

Secondary Outcomes (4)

• Go/No-Go Visual Reaction Time

  Baseline and Day 7

• Trail Making Test Part B Completion Time

  Baseline and Day 7

• Visual Reaction Time

  Baseline and Day 7

• Trail Making Test Part A Completion Time

  Baseline and Day 7

Study Arms (4)

Placebo + Exercise

PLACEBO COMPARATOR

Participants received placebo supplementation using maltodextrin for 7 days and performed high-intensity interval training.

Drug: Placebo; Behavioral: High Intensity Interval Training

Placebo Without Exercise

PLACEBO COMPARATOR

Participants received placebo supplementation using maltodextrin for 7 days without exercise intervention.

Drug: Placebo

Creatine 0,1 g/KgBW/day + Exercise

EXPERIMENTAL

Participants received creatine monohydrate supplementation at 0,1 g/KgBW/day for 7 days and performed high-intensity interval training.

Drug: Creatine Monohydrate; Behavioral: High Intensity Interval Training

Creatine 0,3 g/KgBW/day + Exercise

EXPERIMENTAL

Participants received creatine monohydrate supplementation at 0,3 g/KgBW/day for 7 days and performed high-intensity interval training.

Drug: Creatine Monohydrate; Behavioral: High Intensity Interval Training

Interventions

Creatine Monohydrate DRUG

Creatine monohydrate supplementation at a dose of 0,1 g/KgBW/day for 7 days.

Creatine 0,1 g/KgBW/day + Exercise

Placebo DRUG

Placebo supplementation for 7 days

Placebo + Exercise; Placebo Without Exercise

High Intensity Interval Training BEHAVIORAL

A bodyweight high-intensity interval training program performed in 2 rounds with 40 seconds work and 20 seconds rest in round 1, and 30 seconds work and 15 seconds rest in round 2, with 30 seconds rest between rounds.

Creatine 0,1 g/KgBW/day + Exercise; Creatine 0,3 g/KgBW/day + Exercise; Placebo + Exercise

Eligibility Criteria

• Age: 19 Years - 25 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male sport science students aged 19 to 25 years
• Physically active and accustomed to high-intensity exercise
• Healthy volunteers
• Willing to participate and provide written informed consent
• Willing to complete the 7-day intervention and cognitive testing procedures

You may not qualify if:

• History of cardiovascular disease
• History of kidney disease
• Current use of creatine supplements
• Current use of pre-workout supplements, steroids, or diuretics
• Any musculoskeletal, neurological, or medical condition that could interfere with exercise participation or cognitive testing
• Refusal or inability to complete the study procedures

Sponsors & Collaborators

• Universitas Negeri Malang: lead

Study Sites (1)

Laboratory Sports Science Universitas Negeri Malang

Malang, East Java, 65145, Indonesia

Location

MeSH Terms

Interventions

Creatine; High-Intensity Interval Training

Intervention Hierarchy (Ancestors)

Guanidines; Amidines; Organic Chemicals; Amino Acids; Amino Acids, Peptides, and Proteins; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer, Department of Sport Science,

Model Details: Participants were assigned to one of four parallel groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, and creatine 0.3 g/KgBW/day plus exercise.

Study Record Dates

• First Submitted: April 9, 2026
• First Posted: April 16, 2026
• Study Start: February 7, 2026
• Primary Completion: February 14, 2026
• Study Completion: February 14, 2026
• Last Updated: April 16, 2026

Record last verified: 2026-04

Locations

ID (1)