NCT07475676

Brief Summary

Creatine has been widely studies within the strength and conditioning background and has been seen to show positive effects on performance assess the effects of creatine on sports requiring a range of different fitness components to be successful such as football. Previous research has suggested benefits of creatine supplementation such as increasing PCr (phosphocreatine) stores to aid ATP (adenosine triphosphate) production, increasing muscle water retention resulting in enhanced protein synthesis, reduced muscle damage and anti-inflammation. Identifying supplements that are scientifically proved to aid performance can help optimise training and develop physical ability of athletes to enhance performance.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Mar 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 27, 2026

Completed
2 days until next milestone

Study Start

First participant enrolled

March 1, 2026

Completed
15 days until next milestone

First Posted

Study publicly available on registry

March 16, 2026

Completed
14 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 30, 2026

Completed
14 days until next milestone

Study Completion

Last participant's last visit for all outcomes

April 13, 2026

Completed
Last Updated

March 16, 2026

Status Verified

March 1, 2026

Enrollment Period

29 days

First QC Date

February 27, 2026

Last Update Submit

March 11, 2026

Conditions

Outcome Measures

Primary Outcomes (3)

  • The effects of acute creatine supplementation on semi-pro football player speed test results following a seven-day supplementation period.

    Participants will supplement creatine for a seven day period. Baseline testing will take place before supplementation using a 30m sprint test, it will be measured by the time it took to sprint the 30m (seconds). Participants will undergo the same test after following 7 days. The effects of creatine supplementation will be noted by the difference between sprint test scores (seconds).

    7 days

  • The effects of acute creatine supplementation on semi-pro football player countermovement jump (power) results following a seven-day supplementation period.

    Participants will supplement creatine for a seven-day period. Baseline testing for power will take place before supplementation using a countermovement jump. Participants will undergo the same test after following 7 days. The effects of creatine supplementation will be noted by the difference between countermovement jump scores (power).

    7 days

  • The effects of acute creatine supplementation on semi-pro football player lower limb strength test results completed through a 5-RM leg press test following a seven-day supplementation period.

    Participants will supplement creatine for a seven-day period. Baseline testing will take place before supplementation using a 5-RM leg press, it will be measured by the maximal amount of weight used to complete five reps on the leg press (kg). Participants will undergo the same test after following 7 days. The effects of creatine supplementation will be noted by the difference between the maximal amount of weight used to complete five reps on the leg press (kg)t test scores (seconds).

    7 days

Study Arms (2)

Placebo

PLACEBO COMPARATOR
Dietary Supplement: Placebo

Creatine Supplementation

ACTIVE COMPARATOR
Dietary Supplement: Creatine Monohydrate

Interventions

PlaceboDIETARY_SUPPLEMENT

Placebo

Placebo
Creatine MonohydrateDIETARY_SUPPLEMENT

Creatine Monohydrate

Creatine Supplementation

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Male or female between the age of 18-45
  • Trained individuals currently playing at a semi-professional (regional) level currently training and competing no more than three times a week
  • Free of long-term injuries for the last six months
  • Not supplementing creatine within the last 3 months.
  • Able to swallow pills
  • No medical conditions

You may not qualify if:

  • Individuals will be excluded from participation if they are under the age of 18 or over the age of 45
  • Not currently playing football at a semi-professional (regional) level.
  • Train and/or compete more than three times per week
  • Have any current injury or have experienced a long-term injury within the previous six months that may affect performance or increase the risk of injury during testing.
  • Individuals who have supplemented with creatine within the last three months, - Any medical condition will not be eligible to take part in the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

St Mary's University Twickenham London

London, TW1 4SX, United Kingdom

Location

MeSH Terms

Interventions

Creatine

Intervention Hierarchy (Ancestors)

GuanidinesAmidinesOrganic ChemicalsAmino AcidsAmino Acids, Peptides, and Proteins

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 27, 2026

First Posted

March 16, 2026

Study Start

March 1, 2026

Primary Completion

March 30, 2026

Study Completion

April 13, 2026

Last Updated

March 16, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

Locations