Creatine and Perioperative Brain Health

NCT07310043 | Not Yet Recruiting DMC

• 1 other identifier: 2025P002111
• Study Type: interventional
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this study is to understand the effects of oral creatine supplementation in the perioperative period. Creatine is commonly used to enhance athletic performance, but it can also have positive effects on the brain. Since surgery can lead to alterations in thinking, memory, and attention patterns in some patients, we will assess whether creatine can be protective against these changes in older adults undergoing surgery.

Conditions

Neurocognitive Disorders; Postoperative Delirium

Keywords

Perioperative Brain Health; Creatine; Perioperative Neurocognitive Disorders

Outcome Measures

Primary Outcomes (4)

• Preoperative cognitive function assessed with the Montreal Cognitive Assessment (MoCA)

  The MoCA is a validated tool to assess cognitive function. Scores range from 0-30, with higher scores representing better cognitive function

  Within three weeks before surgery

• Postoperative cognitive function assessed with the Montreal Cognitive Assessment (MoCA)

  The MoCA is a validated tool to assess cognitive function. Scores range from 0-30, with higher scores representing better cognitive function

  Within one month after surgery

• Postoperative cognitive function assessed with the Montreal Cognitive Assessment (MoCA)

  The MoCA is a validated tool to assess cognitive function. Scores range from 0-30, with higher scores representing better cognitive function

  Within three months after surgery

• Postoperative delirium assessed with the Confusion Assessment Method

  The CAM is a validated tool to detect postoperative delirium

  Up to 7 days after surgery

Study Arms (1)

Patients under creatine monohydrate intervention

EXPERIMENTAL

Dietary Supplement: Creatine monohydrate

Interventions

Creatine monohydrate DIETARY_SUPPLEMENT

Participants will receive creatine supplementation before surgery

Patients under creatine monohydrate intervention

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients scheduled for elective surgery under general anesthesia

You may not qualify if:

• History of creatine deficiency disorders
• Severe neurologic or psychiatric diseases
• History of stroke or head trauma
• Obesity (BMI ≥ 30 kg.m-²), kidney or liver disease

Sponsors & Collaborators

• Massachusetts General Hospital: lead

MeSH Terms

Conditions

Neurocognitive Disorders; Emergence Delirium

Interventions

Creatine

Condition Hierarchy (Ancestors)

Mental Disorders; Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Guanidines; Amidines; Organic Chemicals; Amino Acids; Amino Acids, Peptides, and Proteins

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: December 12, 2025
• First Posted: December 30, 2025
• Study Start (Estimated): July 1, 2026
• Primary Completion (Estimated): June 30, 2028
• Study Completion (Estimated): June 30, 2028
• Last Updated: April 21, 2026

Record last verified: 2026-04