NCT07740447

Brief Summary

A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment by means of minimally invasive approach MINST or Q-SI (quadrantwise) approach in subjects with periodontitis on targeted metabolomics in gingival crevicular fluid

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
5mo left

Started May 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress39%
May 2026Dec 2026

Study Start

First participant enrolled

May 4, 2026

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

July 28, 2026

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 31, 2026

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 16, 2026

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

December 18, 2026

Last Updated

July 31, 2026

Status Verified

July 1, 2026

Enrollment Period

7 months

First QC Date

July 28, 2026

Last Update Submit

July 28, 2026

Conditions

Periodontitis

Outcome Measures

Primary Outcomes (1)

  • Probing pocket depth

    Reduction in Probing Pocket Depth after treatment

    6 months

Study Arms (2)

MINST non surgical periodontal treatment

EXPERIMENTAL

Periodontitis patients treated by means of MINST. Patients were treated with non-surgical MINST periodontal treatment in a single session.

Other: Probing depth reduction

Q-SI non surgical periodontal treatment

ACTIVE COMPARATOR

Periodontitis patients treated by means of Q-SI. Patients were treated with non-surgical quadrantwise periodontal treatment in 4 sessions, 1 session per week.

Other: Probing depth reduction

Interventions

Probing depth reductionOTHER

Probing depth reduction in millimetres before and after treatment

MINST non surgical periodontal treatmentQ-SI non surgical periodontal treatment

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Diagnosis of Periodontitis

You may not qualify if:

  • Periodontal treatment during the last 6 months
  • Use of antibiotics, NSAIDs, and immunosuppressants during the last 6 months
  • Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

AOU Policlinico G. Rodolico

Catania, Italy, 95123, Italy

RECRUITING

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal DiseasesMouth DiseasesStomatognathic Diseases

Central Study Contacts

Gaetano Isola

CONTACT

0953785652gaetano.isola@unict.it

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Prof.

Study Record Dates

First Submitted

July 28, 2026

First Posted

July 31, 2026

Study Start

May 4, 2026

Primary Completion (Estimated)

November 16, 2026

Study Completion (Estimated)

December 18, 2026

Last Updated

July 31, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will share

Study results

Shared Documents
STUDY PROTOCOL
Time Frame
1 year
Access Criteria
Pubmed
More information

Locations

IT(1)