Evaluation of Guided Tissue Regeneration With Autogenous Bone Chips and CGF During Implant Placement

NCT07521514 | Not Yet Recruiting

• 1 other identifier: omfs3-3-20
• Study Type: interventional
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

CGF membranes will be prepared using a swing-lock centrifuge. A full-thickness mucoperiosteal flap will be elevated in a narrow alveolar ridge. Implants will be inserted. Autologous bone chips will be harvested via bone scraping and used for augmentation, CGF membranes will be placed over the grafted area. Suturing of the mucoperiosteal flap. Radiographic evaluation of the bone density and tissue thickness will be performed by CBCT preoperatively, immediate postoperative and after the procedure by 4 months. Clinical evaluation of the tissue thickness using periodontal probe preoperatively, immediate postoperatively and after the procedure by 4 months

Conditions

Alveolar Ridge Augmentation; Dental Implant; Alveolar Bone Loss

Keywords

CGF; autogenous bone graft; gingival biotype; dental implant; guided tissue regeneration

Outcome Measures

Primary Outcomes (1)

• tissue biotype

  using periodontal probe to measure gingival thickness

  preoperative, immediate postoperative and 4 months after the procedure

Secondary Outcomes (2)

• bone density

  preoperative, immediately postoperative, and 4 months after the surgery

• patient satisfaction

  after 4 months from the surgery

Study Arms (1)

GTR with Autogenous Bone Chips and CGF Membrane

OTHER

Other: concentrated growth factor (CGF) Membrane

Interventions

concentrated growth factor (CGF) Membrane OTHER

This is a third-generation autologous blood concentrate prepared using a dedicated centrifuge system. The process creates a fibrin-rich organic matrix from the patient's own blood, which is then molded into a membrane and packed over the grafted bone to enhance bone density increase and improvement of the surrounding tissue.

GTR with Autogenous Bone Chips and CGF Membrane

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• A medical history that contraindicates oral surgical treatment such as (uncontrolled/untreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and/or intravenous bisphosphonates).
• Presence of active or untreated periodontal disease.
• Vertical root fractures involving the buccal aspect.
• Tooth /teeth with horizontal fractures below bone level.
• Tooth /teeth with external or internal resorption.
• Patients with destructive oral habits such as smoking, chewing tobacco, bruxism,etcetera(Chrcanovic et al., 2014).

You may not qualify if:

• Presence of active or untreated periodontal disease.
• Vertical root fractures involving the buccal aspect.
• Tooth /teeth with horizontal fractures below bone level.
• Tooth /teeth with external or internal resorption.
• Patients with destructive oral habits such as smoking, chewing tobacco, bruxism, etcetera(Chrcanovic et al., 2014).

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Giza, Cairo Governorate, 12511, Egypt

Location

MeSH Terms

Conditions

Alveolar Bone Loss

Condition Hierarchy (Ancestors)

Bone Resorption; Bone Diseases; Musculoskeletal Diseases; Periodontal Atrophy; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Hesham Elsayed Elhawary, Professor

  Cairo University

  STUDY CHAIR

• Abdelmoez Mohamed El-Sharkawy, Assistant Professor

  Cairo University

  STUDY DIRECTOR

Central Study Contacts

meis youssef moustafa, bachelors

CONTACT

00201065186643; meis.eltanany@dentistry.cu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principle investigator

Study Record Dates

• First Submitted: April 3, 2026
• First Posted: April 13, 2026
• Study Start: April 16, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: April 13, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)