Effect of AED-optimized Telephone-assisted CPR Instructions on No-flow Time and Chest Compression Fraction

NCT07520877 | Recruiting

• 1 other identifier: DA-CPR and AED
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Out-of-hospital cardiac arrest (OHCA) remains a leading cause of mortality worldwide, with survival highly dependent on the immediate initiation of bystander cardiopulmonary resuscitation (CPR). Early recognition, prompt chest compressions, and rapid defibrillation are critical components of the chain of survival. Telephone-assisted CPR (T-CPR) provided by emergency dispatchers has been shown to significantly increase bystander intervention rates and improve outcomes. While the availability and use of automated external defibrillators (AEDs) further enhance survival, the optimal integration of AED use into dispatcher-guided, single-rescuer scenarios remains insufficiently studied. This prospective, randomized, controlled simulation study aims to evaluate the effect of modified telephone cardiopulmonary resuscitation (T-CPR) instructions optimized for automated external defibrillator (AED) use on no-flow time and chest compression fraction (CCF) during single-rescuer resuscitation. Participants are randomized to receive either standard T-CPR instructions or enhanced instructions focusing on minimizing interruptions in chest compressions and reducing time to first compression during AED use.

Conditions

Cardiac Arrest (CA)

Keywords

cardiac arrest; automated external defibrillator; dispatcher-assisted cardiopulmonary resuscitation; no-flow time; chest compression fraction

Outcome Measures

Primary Outcomes (1)

• No-flow time

  Time without chest compressions measured from entry into the simulation (collapse recognition) until termination of the scenario (giving the third shock).

  During procedure.

Secondary Outcomes (4)

• Time to first chest compression

  During procedure.

• Time to first shock

  During procedure

• Chest compression fraction

  During procedure.

• Peri-shock pause

  During procedure

Other Outcomes (1)

• Attitude about T-CPR instructions

  Immediately after the CPR procedure (within 15 minutes)

Study Arms (2)

Standard T-CPR

EXPERIMENTAL

Participants perform dispatcher-assisted CPR based on the European Resuscitation Council (ERC) 2025 guidelines and the national standard DA-CPR protocol.

Behavioral: T-CPR

AED-optimized T-CPR

ACTIVE COMPARATOR

Participants perform dispatcher-assisted CPR based on the European Resuscitation Council (ERC) 2025 guidelines and a modified national DA-CPR protocol.

Behavioral: AED-optimized T-CPR

Interventions

T-CPR BEHAVIORAL

Participants receive structured telephone CPR instructions reflecting current national practice. AED retrieval is instructed early; however, no additional guidance is provided to optimize timing or minimize interruptions during AED use.

Standard T-CPR

AED-optimized T-CPR BEHAVIORAL

Participants receive standard T-CPR instructions supplemented with specific guidance aimed at: * minimizing interruptions in chest compressions, * reducing time to first chest compression, * optimizing AED use workflow. Key elements include: * immediate activation of the AED upon retrieval, * initiation of chest compressions even if AED voice prompts have not yet reached relevant steps, * continuation of compressions during AED preparation and charging (when appropriate), * minimization of pauses before and after shock delivery.

AED-optimized T-CPR

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Adolescents and adults (≥16 years)
• Healthcare professionals or laypersons
• Voluntary participation

You may not qualify if:

• pregnant women
• people with cardio-pulmonary and musculoskeletal diseases or any other impairment that would risk harm for the volunteer while performing CPR
• physical and/or psychological disabilities
• technical issue during data collection

Sponsors & Collaborators

• University of Pecs: lead

Study Sites (1)

University of Pécs

Pécs, 7621, Hungary

RECRUITING

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Central Study Contacts

Bálint Bánfai, Ph.D.

CONTACT

+3630501500; balint.banfai@etk.pte.hu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Participants will be informed about their group assignment post-randomization but will be blinded to the study's aims. The dispatcher will be briefed on their specific tasks but will remain blinded to the study hypotheses and outcomes.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: April 2, 2026
• First Posted: April 9, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): July 31, 2026
• Study Completion (Estimated): August 31, 2026
• Last Updated: April 14, 2026

Record last verified: 2026-04

Locations

HU (1)