Incidence of Colon Ischemia in Patients After Cardiopulmonary Resuscitation (CPR)

NCT07359313 | Not Yet Recruiting

• 1 other identifier: 24-1320-S1
• Study Type: interventional
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Bedside colonoscopy 24-36 hours after successful CPR

Conditions

Cardiac Arrest (CA)

Keywords

cardiac arrest; cardiopulmonary resuscitation; CPR; extracorporeal cardiopulmonary resuscitation; ECPR; VA ECMO; colonoscopy; mesenteric ischemia

Outcome Measures

Primary Outcomes (1)

• Detection of colon ischemia

  Detection of colon ischemia within 30 days after return of spontaneous circulation

  from baseline (0 hours) until day 30

Secondary Outcomes (10)

• in-hospital mortality

  from baseline (0 hours) until hospital discharge

• abdominal surgery ((hemi-)colectomy)

  from baseline (0 hours) until hospital discharge

• functional outcome

  day 30, day 60 and day 90

• Liver function

  within 0-72 hours after CPR

• renal function

  within 0-72 hours after CPR

Study Arms (1)

early colonoscopy after successful CPR

OTHER

bedside colonoscopy 24-36 hours after successful CPR

Procedure: colonoscopy

Interventions

colonoscopy PROCEDURE

bedside colonoscopy without bowel cleansing early (24-36h) after successful CPR

early colonoscopy after successful CPR

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• adult patients (≥ 18 years) admitted to the participating department AND
• in-hospital or out-of-hospital cardiac arrest (IHCA, OHCA)

You may not qualify if:

• resuscitation period of ≤ 5 minutes
• awake and contactable patients (GCS ≥ 13)

Sponsors & Collaborators

• University Hospital Freiburg: lead

Study Sites (1)

Medical Center - University of Freiburg

Freiburg im Breisgau, 79106, Germany

Location

MeSH Terms

Conditions

Heart Arrest; Mesenteric Ischemia

Interventions

Colonoscopy

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Peritoneal Diseases; Vascular Diseases

Intervention Hierarchy (Ancestors)

Endoscopy, Gastrointestinal; Endoscopy, Digestive System; Diagnostic Techniques, Digestive System; Diagnostic Techniques and Procedures; Diagnosis; Endoscopy; Diagnostic Techniques, Surgical; Digestive System Surgical Procedures; Surgical Procedures, Operative; Minimally Invasive Surgical Procedures

Central Study Contacts

Alexander Supady, MD, MPH

CONTACT

+49-761-270-34010; alexander.supady@uniklinik-freiburg.de

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Physician

Model Details: Prospective epidemiological incidence study

Study Record Dates

• First Submitted: December 19, 2025
• First Posted: January 22, 2026
• Study Start: January 7, 2026
• Primary Completion (Estimated): January 6, 2028
• Study Completion (Estimated): February 6, 2028
• Last Updated: January 22, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)