NONSURG
Impact of Non-surgical Periodontal Therapy on Inflammatory Mediators in the Gingival Crevicular Fluid of Patients With Severe Periodontitis
Sponsor study identifier
Secondary identifiers
OTHER · REK
observational
30
1 country
1
Study Start
January 8, 2016
Actual (reported)Primary Completion
December 21, 2025
Actual (reported)Study Completion
December 21, 2025
Actual (reported)This study investigates inflammatory biomarkers in gingival crevicular fluid (GCF) from smokers and non-smokers with severe periodontitis, before and during non-surgical periodontal therapy (NSPT). During periodontal disease development the periodontal pockets become deeper. In the inflamed periodontal tissue the interstitial fluid is filtered out into the periodontal pocket. The GCF reflects local inflammatory activity and contains cytokines/chemokines that may serve as biomarkers for disease severity and treatment response. Investigators aim at collecting GCF from periodontal pockets from each patients before and during NSPT. Investigators compare non-smokers and smokers. The samples will be analysed for pro-inflammatory mediators and investigators aim at biomarkers that are at a high level in deep inflamed periodontal pockets. Investigators also want to observe if these biomarkers are altered in GCF after periodontal therapy. Finally investigators want to compare non-smokers and smokers with respect to treatment outcome and respons of chemokines/cytokines in GCF.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 21, 2025
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 8, 2016
Actual (reported)December 21, 2025
Actual (reported)December 21, 2025
Actual (reported)February 5, 2026
Actual (reported)March 31, 2026
Actual (reported)Biomarker measurement in GCF
Analyse the GCF for 40 biomarkers
Within a period of 5 years
Applying a paperpoint in a periodontal pocket for 30 sec
Non surgical treatment of periodontitis patients
We are looking at spesific biomarkers in GCF that has not been investigated before
Patients with severe periodontitis referred to our specialist clinic
Contact the study team to confirm eligibility.
Postboks 2354 Møllendal
Bergen, 5867, Norway
30 participants (actual enrollment reported by the registry).
First Submitted
February 5, 2026
First Posted
March 31, 2026
Study Start
January 8, 2016
Actual (reported)Effects of Ozone Therapy as an Adjunct to Periodontal Treatment
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Primary Completion
December 21, 2025
Actual (reported)Study Completion
December 21, 2025
Actual (reported)Last Updated
March 31, 2026
Record last verified: 2026-03
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Source: ClinicalTrials.gov.
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