NCT07695857

Brief Summary

This study aimed to evaluate gingival crevicular fluid (GCF) and serum levels of Adropin and tumor necrosis factor (TNF)-alfa in patients with periodontitis before and after non-surgical periodontal therapy.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Apr 2018

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 2, 2018

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 2, 2020

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 6, 2020

Completed
5.7 years until next milestone

First Submitted

Initial submission to the registry

July 6, 2026

Completed
4 days until next milestone

First Posted

Study publicly available on registry

July 10, 2026

Completed
Last Updated

July 10, 2026

Status Verified

January 1, 2026

Enrollment Period

2.4 years

First QC Date

July 6, 2026

Last Update Submit

July 6, 2026

Conditions

Periodontitis

Keywords

periodontitisAdropingingival crevicular fluidserum

Outcome Measures

Primary Outcomes (1)

  • 1. Adropin levels

    Changes in Adropin levels before and after periodontal therapy

    Baseline and at 6 weeks after therapy

Secondary Outcomes (1)

  • TNF-alfa levels

    baseline and at 6 weeks after therapy

Study Arms (2)

Group 1: Periodontally healthy individuals

Group 2: Periodontitis patients

Procedure: Nonsurgical periodontal therapy

Interventions

Nonsurgical periodontal therapyPROCEDURE

Nonsurgical periodontal therapy includes oral hygiene education and scaling and root planning approaches to eliminate microbial dental biofilm that is the primary etiology of periodontal diseases.

Group 2: Periodontitis patients

Eligibility Criteria

Age27 Years - 49 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Criteria for healthy control group: BOP \< 10% and PD ≤ 3 mm without clinical attachment loss or radiographic sign of alveolar bone destruction. Criteria for periodontitis group: interdental CAL ≥ 5 mm at least 2 non-adjacent teeth, PD ≥ 6 mm and radiographic bone loss extending to the mid-third of the root or beyond.

You may qualify if:

  • having at least 20 natural teeth, excluding third molars
  • having no systemic disease
  • non-smokers
  • Diagnosed with periodontally health and periodontitis patients

You may not qualify if:

  • having any systemic diseases
  • smoking
  • current pregnancy or lactation
  • a history of periodontal treatment in the past 6 months
  • using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Giresun University

Giresun, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

gingival crevicular fluid and serum

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal DiseasesMouth DiseasesStomatognathic Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assoc. Prof., DDS, PhD

Study Record Dates

First Submitted

July 6, 2026

First Posted

July 10, 2026

Study Start

April 2, 2018

Primary Completion

September 2, 2020

Study Completion

November 6, 2020

Last Updated

July 10, 2026

Record last verified: 2026-01

Locations

TU(1)