Effect Of Non-Surgical Periodontal Treatment On Lipoxin a4 Levels

NCT04053660 | Completed DMC

• 1 other identifier: Ordu dental faculty
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to evaluate the levels of lipoxin A4 (LXA4), prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in gingival crevicular fluid (GCF) and saliva in individuals with periodontal healthy and chronic periodontitis. In addition, the investigators evaluated the levels of these mediators after non-surgical periodontal treatment in patients with chronic periodontitis. A total of 20 subjects, 10 patients with chronic periodontitis (CP) and 10 periodontally healthy individuals were included in the study. Clinical parameters including plaque index (PI), gingival index (GI), probing depth (PD) and clinical attachment levels (CAL) were recorded. GCF and saliva samples were obtained at the beginning of the study from all individuals. GCF and saliva samples were re-collected from patients with CP at 1 month after non surgical periodontal therapy.

Conditions

Periodontitis

Keywords

Gingival Crevicular Fluid; Lipid Mediator; Periodontal Treatment

Outcome Measures

Primary Outcomes (1)

• Lipoxin A4 levels

  change of gingival crevicular fluid and salivary Lipoxin A4 levels from baseline at 1st month

  1st month

Secondary Outcomes (2)

• Prostaglandin E2 levels

  1st month

• Leukotriene B4

  1st month

Study Arms (2)

Control

NO INTERVENTION

Periodontally healthy group

Chronic Periodontitis

EXPERIMENTAL

Patients with chronic periodontitis

Procedure: Non-surgical periodontal treatment

Interventions

Non-surgical periodontal treatment PROCEDURE

Mechanical non-surgical treatment were performed

Chronic Periodontitis

Eligibility Criteria

• Age: 25 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Have at least 20 natural teeth, excluding third molars.
• Chronic periodontitis patients had at least two non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and clinical attachment level (CAL) ≥ 5 mm with gingival inflammation, and alveolar bone loss affecting \>30% of the teeth, as detected on clinical and radiographical examinations.
• Periodontally healthy control group had no sign of gingival inflammation, no PD \> 3mm and no evidence of attachment or bone loss.

You may not qualify if:

• History of systemic disease.
• Regular use of any drugs which can effect the immune system or inflammatory response in the 6 months preceding the start of the study.
• Periodontal treatment during last 6 months that could affect periodontal status.
• Smoking.
• History of radiotherapy or chemotherapy.
• Ongoing orthodontic treatment.
• Aggressive periodontitis.
• Current pregnancy, lactation or menopause.

Sponsors & Collaborators

• Ordu University: lead

Study Sites (1)

Ordu University

Ordu, 52200, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Ceren Gokmenoglu

  Ordu University Faculty of Dentistry

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal invesitgator

Study Record Dates

• First Submitted: August 2, 2019
• First Posted: August 12, 2019
• Study Start: October 1, 2017
• Primary Completion: December 31, 2018
• Study Completion: December 31, 2018
• Last Updated: August 12, 2019

Record last verified: 2019-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)