The Influence of Smoking in Periodontitis Patients, Before and After Nonsurgical Treatment

NCT04974502 | Completed DMC

• 1 other identifier: 92/DHYD-HDDD
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Objective: The aim of this study was to evaluate and compare the oral neutrophil numbers (ONN) in saliva, the level of matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF) and the periodontal parameters in smokers and non-smokers with periodontitis, before and after nonsurgical periodontal treatment (NSPT). Materials and method: 40 periodontitis patients including 20 smokers and 20 non-smokers were enrolled in this study. All patients were received the NSPT included instructing oral hygiene, scaling and root planning. Clinical parameters (plaque index (PlI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment loss (CAL)), ONN and GCF MMP-8 level were assessed before (baseline) and after NSPT 1 month and 3 months.

Conditions

Periodontitis

Keywords

periodontitis; smoking; neutrophil; matrix metalloproteinase-8; nonsurgical treatment

Outcome Measures

Primary Outcomes (5)

• Oral neutrophils

  The number of neutrophils in saliva

  At baseline (T0)

• Oral neutrophils

  The number of neutrophils in saliva

  After Nonsurgical periodontal treatment one month (T1)

• Oral neutrophils

  The number of neutrophils in saliva

  After Nonsurgical periodontal treatment three months (T3)

• Matrix metalloproteinase-8 (MMP-8)

  The level of matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid

  At baseline (T0).

• Matrix metalloproteinase-8 (MMP-8)

  The level of matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid

  After Nonsurgical periodontal treatment three months (T3)

Secondary Outcomes (11)

• Plaque Index (PlI)

  At baseline (T0).

• Plaque Index (PlI)

  After Nonsurgical periodontal treatment one month (T1)

• Plaque Index (PlI)

  After Nonsurgical periodontal treatment three months (T3)

• Gingival Index (GI)

  At baseline (T0).

• Gingival Index (GI)

  After Nonsurgical periodontal treatment one month (T1)

Study Arms (2)

Non-smoker group

EXPERIMENTAL

Procedure: Nonsurgical periodontal treatment

Smoker group

EXPERIMENTAL

Procedure: Nonsurgical periodontal treatment

Interventions

Nonsurgical periodontal treatment PROCEDURE

Oral hygiene instructions, scaling and root planning.

Non-smoker group; Smoker group

Eligibility Criteria

• Age: 30 Years - 60 Years
• Gender Eligibility Details: Smoking male
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Male patients
• Aged from 30 to 60 years old
• Systemically healthy
• Having at least 20 teeth
• Diagnosed with moderate to severe periodontitis according to american academy of periodontology 2015: gingival bleeding at examination, ≥5mm periodontal pocket depth (PPD), bone resorption on x-ray film ≥16% or \>3mm root length
• Having at least two sites at anterior teeth with PPD from 5 to 7 mm
• For group 1, subjects who never smoke
• For group 2, subjects who had smoked more than 10 cigarettes per day for at least the past 10 years

You may not qualify if:

• Patients with acute or chronic medical disorders
• Patients under any medication for the past 3 months
• Patients who had undergone periodontal therapy in the last 12 months
• Patients with oral lesions such as ulcers, aphthous ulcers, glossitis or multi tooth decays

Sponsors & Collaborators

• University of Medicine and Pharmacy at Ho Chi Minh City: lead

Related Publications (3)

• Al-Ghamdi HS, Anil S. Serum antibody levels in smoker and non-smoker saudi subjects with chronic periodontitis. J Periodontol. 2007 Jun;78(6):1043-50. doi: 10.1902/jop.2007.060431.

  PMID: 17539718 RESULT

• Akbari G, Prabhuji ML, Karthikeyan BV, Raghunatha K, Narayanan R. Analysis of matrix metalloproteinase-8 levels in gingival crevicular fluid and whole mouth fluid among smokers and nonsmokers using enzyme-linked immune-sorbent assay and a novel chair-side test. J Indian Soc Periodontol. 2015 Sep-Oct;19(5):525-30. doi: 10.4103/0972-124X.162201.

  PMID: 26644719 RESULT

• Do HT, Nguyen TT, Vo TL, Huynh NC, Nguyen ATK. The influence of smoking on oral neutrophils and matrix metalloproteinase-8 in periodontitis patients before and after nonsurgical treatment. J Oral Biol Craniofac Res. 2023 May-Jun;13(3):442-447. doi: 10.1016/j.jobcr.2023.05.004. Epub 2023 May 8.

  PMID: 37215391 DERIVED

MeSH Terms

Conditions

Periodontitis; Smoking

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Dean of Faculty of Odonto-stomatology

Study Record Dates

• First Submitted: July 1, 2021
• First Posted: July 23, 2021
• Study Start: June 1, 2016
• Primary Completion: December 1, 2018
• Study Completion: March 1, 2019
• Last Updated: July 23, 2021

Record last verified: 2021-07

Data Sharing

• IPD Sharing: Will not share