Superficial vs Deep Serratus Anterior Plane Block for Analgesia After Mammoplasty

NCT07502846 | Active Not Recruiting DMC

• 1 other identifier: 46-2025
• Study Type: interventional
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

The serratus anterior plane block (SAPB) is an ultrasound-guided fascial plane block used for perioperative analgesia in thoracic and breast surgeries. This technique involves the injection of local anesthetic into either the superficial or deep interfascial plane around the serratus anterior muscle at the mid-axillary line, targeting the lateral cutaneous branches of the intercostal nerves and providing analgesia to the anterolateral thoracic wall. The present prospective, comparative, single-blind clinical study aims to compare the postoperative analgesic efficacy of superficial and deep SAPB techniques in patients undergoing mammoplasty surgery. The primary objective is to evaluate total opioid consumption within the first 24 hours postoperatively,while secondary outcomes include postoperative pain scores,additional analgesic requirements, postoperative nausea and vomiting, patient satisfaction, time to first mobilization, and vital signs within the first 24 hours postoperatively. The results of this study may help determine the more effective SAPB technique for improving postoperative pain control and reducing opioid use in patients undergoing mammoplasty.

Conditions

Postoperative Pain Management; Analgesia, Postoperative; Breast Surgery; Mammoplasty Patient; Opioid Consumption

Keywords

Serratus Anterior Plane Block; SAPB; Mammoplasty; Breast Surgery; Postoperative Analgesia; Postoperative Pain; Opioid Consumption

Outcome Measures

Primary Outcomes (1)

• Total opioid consumption

  Total opioid consumption required for postoperative analgesia in patients undergoing mammoplasty surgery.

  Within the first 24 hours postoperatively

Secondary Outcomes (9)

• Postoperative pain score (Numeric Rating Scale)

  Within the first 24 hours postoperatively

• Additional analgesic requirement

  Within the first 24 hours postoperatively

• Postoperative nausea and vomiting

  Within the first 24 hours postoperatively

• Patient satisfaction score and Quality of Recovery Score (QoR-15)

  Within the first 24 hours postoperatively

• Time to first mobilization

  Within the first 24 hours postoperatively

Study Arms (2)

Superficial Serratus Anterior Plane Block

EXPERIMENTAL

Patients undergoing mammoplasty surgery who receive an ultrasound-guided superficial serratus anterior plane block for postoperative analgesia.

Procedure: Superficial Serratus Anterior Plane Block

Deep Serratus Anterior Plane Block

EXPERIMENTAL

Patients undergoing mammoplasty surgery who receive an ultrasound-guided deep serratus anterior plane block for postoperative analgesia.

Procedure: Deep Serratus Anterior Plane Block

Interventions

Superficial Serratus Anterior Plane Block PROCEDURE

Ultrasound-guided superficial serratus anterior plane block performed at the mid-axillary line by injecting bupivacaine between the latissimus dorsi and serratus anterior muscles to provide postoperative analgesia in patients undergoing mammoplasty surgery.

Superficial Serratus Anterior Plane Block

Deep Serratus Anterior Plane Block PROCEDURE

Ultrasound-guided deep serratus anterior plane block performed at the mid-axillary line by injecting bupivacaine between the serratus anterior muscle and the ribs to provide postoperative analgesia in patients undergoing mammoplasty surgery.

Deep Serratus Anterior Plane Block

Eligibility Criteria

• Age: 18 Years - 75 Years
• Gender Eligibility Details: The study includes female patients because mammoplasty surgery is performed in women.
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Female patients aged 18-75 years
• ASA physical status I-III
• Patients scheduled for elective mammoplasty surgery (unilateral or bilateral)
• Patients who voluntarily agree to participate in the study and provide informed consent

You may not qualify if:

• ASA physical status IV or higher
• Patients who refuse to participate in the study
• Patients who cannot provide informed consent due to language barriers
• Pregnant patients
• Active infection at the block application site
• Previous surgery affecting the anatomical integrity of the block area
• Known allergy to local anesthetic agents
• Patients with chronic pain or regular analgesic use
• Patients with coagulation disorders
• Patients with neurological or psychiatric disorders affecting pain perception or those using regular antipsychotic or antidepressant medications
• Body mass index (BMI) \> 40 kg/m²

Sponsors & Collaborators

• Başakşehir Çam & Sakura City Hospital: lead

Study Sites (1)

Başakşehir Çam & Sakura City Hospital

Istanbul, Basaksehir, 34480, Turkey (Türkiye)

Location

Related Publications (4)

• Blanco R, Parras T, McDonnell JG, Prats-Galino A. Serratus plane block: a novel ultrasound-guided thoracic wall nerve block. Anaesthesia. 2013 Nov;68(11):1107-13. doi: 10.1111/anae.12344. Epub 2013 Aug 7.

  PMID: 23923989 BACKGROUND

• Bartels K, Mayes LM, Dingmann C, Bullard KJ, Hopfer CJ, Binswanger IA. Opioid Use and Storage Patterns by Patients after Hospital Discharge following Surgery. PLoS One. 2016 Jan 29;11(1):e0147972. doi: 10.1371/journal.pone.0147972. eCollection 2016.

  PMID: 26824844 BACKGROUND

• von Sperling ML, Hoimyr H, Finnerup K, Jensen TS, Finnerup NB. Persistent pain and sensory changes following cosmetic breast augmentation. Eur J Pain. 2011 Mar;15(3):328-32. doi: 10.1016/j.ejpain.2010.07.004. Epub 2010 Aug 19.

  PMID: 20727797 BACKGROUND

• Gerbershagen HJ, Aduckathil S, van Wijck AJ, Peelen LM, Kalkman CJ, Meissner W. Pain intensity on the first day after surgery: a prospective cohort study comparing 179 surgical procedures. Anesthesiology. 2013 Apr;118(4):934-44. doi: 10.1097/ALN.0b013e31828866b3.

  PMID: 23392233 BACKGROUND

MeSH Terms

Conditions

Agnosia; Pain, Postoperative

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Postoperative Complications; Pathologic Processes; Pain

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ASSOCIATE PROFESSOR

Study Record Dates

• First Submitted: March 14, 2026
• First Posted: March 31, 2026
• Study Start: November 15, 2024
• Primary Completion: March 22, 2026
• Study Completion: April 1, 2026
• Last Updated: March 31, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)