Perioperative Analgesic Effects of PENG Versus PENG Plus LFCN Block in Hip Surgeries

NCT07329829 | Active Not Recruiting

• 1 other identifier: BSH-ANES-MG-01
• Study Type: interventional
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

This study is designed to find the best way to control pain after hip surgery performed through a side (lateral) incision. Two different types of nerve blocks used before the operation will be compared. In one group, patients will receive a Pericapsular Nerve Group (PENG) block, which numbs the main nerves that carry pain signals from the hip joint. In the other group, patients will receive a PENG block together with a Lateral Femoral Cutaneous Nerve (LFCN) block, which adds extra pain relief for the skin and outer part of the thigh. A total of 72 patients between 18 and 80 years old will take part in this study. All operations will be done under spinal anesthesia. Pain levels will be measured several times during the first 24 hours after surgery using a simple 0-10 pain scale. Patients will receive pain medicine through a pump that allows them to press a button when they feel pain. The total amount of medicine used will be recorded. The researchers will also monitor when patients first need pain medicine, when they can start walking, how satisfied they are with pain control, and if they experience side effects such as nausea or dizziness. By comparing the two methods, the study aims to see whether adding the LFCN block to the PENG block provides better pain control, lower drug use, faster recovery, and higher patient comfort after hip surgery.

Conditions

Postoperative Pain Management; Analgesia, Postoperative; Regional Anesthesia Success; HİP FRACTURE; Hip Surgery (Lateral Incision)

Keywords

Pericapsular Nerve Group Block (PENG Block); Lateral Femoral Cutaneous Nerve Block (LFCN Block); Hip Surgery; Regional Anesthesia; Postoperative Analgesia; Pain Control; Opioid Consumption; Early Mobilization

Outcome Measures

Primary Outcomes (1)

• Postoperative Pain Intensity (NRS Score)

  Postoperative pain intensity will be assessed using the Numeric Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain), both at rest and during movement.

  2, 6, 12, and 24 hours postoperatively

Secondary Outcomes (3)

• Total Postoperative Opioid Consumption

  First 24 hours postoperatively

• Patient Satisfaction Score

  Within the first 24 hours postoperatively

• Time to First Mobilization

  Within the first 24 hours postoperatively

Study Arms (2)

PENG BLOCK GROUP

EXPERIMENTAL

An ultrasound-guided Pericapsular Nerve Group (PENG) block will be performed preoperatively using standard local anesthetic techniques to provide postoperative analgesia in patients undergoing lateral incision hip surgery.

Procedure: Pericapsular nerve group (PENG) block

PENG + LFCN BLOCK GROUP

EXPERIMENTAL

Patients in this group will receive a preoperative ultrasound-guided Pericapsular Nerve Group (PENG) block combined with a Lateral Femoral Cutaneous Nerve (LFCN) block for postoperative analgesia prior to lateral incision hip surgery under spinal anesthesia.

Procedure: Pericapsular nerve group (PENG) block; Procedure: Lateral Femoral Cutaneous Nerve (LFCN) Block

Interventions

Lateral Femoral Cutaneous Nerve (LFCN) Block PROCEDURE

An ultrasound-guided Lateral Femoral Cutaneous Nerve (LFCN) block will be performed preoperatively as an adjunct to the PENG block to enhance postoperative analgesia in patients undergoing lateral incision hip surgery.

PENG + LFCN BLOCK GROUP

Pericapsular nerve group (PENG) block PROCEDURE

An ultrasound-guided Pericapsular Nerve Group (PENG) block will be performed preoperatively using standard local anesthetic techniques to provide postoperative analgesia in patients undergoing lateral incision hip surgery.

PENG + LFCN BLOCK GROUP; PENG BLOCK GROUP

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged between 18 and 80 years
• Patients scheduled for elective or trauma-related hip surgery performed through a lateral incision under spinal anesthesia
• Patients receiving a preoperative ultrasound-guided Pericapsular Nerve Group (PENG) block or a PENG block combined with a Lateral Femoral Cutaneous Nerve (LFCN) block
• American Society of Anesthesiologists (ASA) physical status I-III
• Patients with full orientation and the ability to cooperate
• Ability to understand the study procedures and provide written informed consent

You may not qualify if:

• Contraindications to regional anesthesia, including coagulopathy or local infection at the injection site
• Presence of neuropathic disorders or conditions that may affect pain perception, including chronic analgesic use
• Requirement for conversion to general anesthesia
• Postoperative admission to the intensive care unit
• Known allergy or hypersensitivity to opioids or local anesthetics
• American Society of Anesthesiologists (ASA) physical status IV-V

Sponsors & Collaborators

• Başakşehir Çam & Sakura City Hospital: lead

Study Sites (1)

Basaksehir Çam and Sakura City Hospital

Istanbul, BASAKSEHİR, 34490, Turkey (Türkiye)

Location

Related Publications (4)

• Roy R, Agarwal G, Pradhan C, Kuanar D. Total postoperative analgesia for hip surgeries, PENG block with LFCN block. Reg Anesth Pain Med. 2019 Mar 28:rapm-2019-100454. doi: 10.1136/rapm-2019-100454. Online ahead of print. No abstract available.

  PMID: 30923252 BACKGROUND

• Yoo SH, Lee MJ, Beak MH, Kim WJ. Efficacy of Supplemental Ultrasound-Guided Pericapsular Nerve Group (PENG) Block Combined with Lateral Femoral Cutaneous Nerve Block in Patients Receiving Local Infiltration Analgesia after Hip Fracture Surgery: A Prospective Randomized Controlled Trial. Medicina (Kaunas). 2024 Feb 12;60(2):315. doi: 10.3390/medicina60020315.

  PMID: 38399602 BACKGROUND

• Pascarella G, Costa F, Strumia A, Ruggiero A, Remore LM, Lanteri T, Hazboun A, Longo F, Gargano F, Schiavoni L, Mattei A, Agro FE, Carassiti M, Cataldo R. Lateral Femoral Cutaneous Nerve Block or Wound Infiltration Combined with Pericapsular Nerve Group (PENG) Block for Postoperative Analgesia following Total Hip Arthroplasty through Posterior Approach: A Randomized Controlled Trial. J Clin Med. 2024 May 2;13(9):2674. doi: 10.3390/jcm13092674.

  PMID: 38731203 BACKGROUND

• Liang L, Zhang C, Dai W, He K. Comparison between pericapsular nerve group (PENG) block with lateral femoral cutaneous nerve block and supra-inguinal fascia iliaca compartment block (S-FICB) for total hip arthroplasty: a randomized controlled trial. J Anesth. 2023 Aug;37(4):503-510. doi: 10.1007/s00540-023-03192-6. Epub 2023 Apr 12.

  PMID: 37043081 BACKGROUND

MeSH Terms

Conditions

Hip Fractures; Agnosia

Interventions

Dental Occlusion

Condition Hierarchy (Ancestors)

Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries; Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Dentistry; Dental Physiological Phenomena; Digestive System and Oral Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ASSOCIATE PROFESSOR

Study Record Dates

• First Submitted: December 27, 2025
• First Posted: January 9, 2026
• Study Start: November 1, 2025
• Primary Completion: February 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: January 12, 2026

Record last verified: 2025-07

Locations

TU (1)