Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy

NCT07497958 | Not Yet Recruiting DMC

• 1 other identifier: B2026-114
• Study Type: interventional
• Target: 174
• Locations: 1 country
• Sites: 1

Brief Summary

It is demonstrated that remote ischemic preconditioning can alleviate the degree of acute renal injury on the operated side in patients undergoing partial nephrectomy.

Conditions

Renal Cell Carcinoma (RCC); Renal Function Abnormal

Keywords

Renal Function Abnormal; Acute kidney injury; Partial nephrectomy; Ischemic preconditioning

Outcome Measures

Primary Outcomes (1)

• AIRD spectrum score based on the patient's preoperative creatinine level and postoperative peak creatinine level

  The AIRD spectrum score was defined as: (observed peak SCr - SCr ideal-peak)/(SCr worstcase-peak - SCr ideal-peak） The range of this indicator should be between 0 and 1, with 0 and 1 representing two extreme situations. 0 indicates that the kidney on the operated side is completely undamaged, while 1 indicates that the kidney on the operated side has completely lost its function.

  2 weeks after partial nephrectomy

Secondary Outcomes (1)

• Recovery from ischemia based on the changes in creatinine levels before and after the partial nephrectomy and volume retention rate after the partial nephrectomy

  3 month after surgery

Study Arms (2)

Experimental : Ischemic preconditioning

EXPERIMENTAL

One day before the surgery, use a sphygmomanometer to apply pressure to the patient's upper limb to 200mmHg for 5 minutes, then reduce the pressure to 0mmHg for 5 minutes, repeating this process for a total of 3 cycles. On the second day, perform a routine partial nephrectomy

Procedure: Ischemic preconditioning

Comparator : No ischemic preconditioning

ACTIVE COMPARATOR

Routine partial nephrectomy

Procedure: NO ischemic preconditioning

Interventions

Ischemic preconditioning PROCEDURE

One day before the surgery, use a sphygmomanometer to apply pressure to the patient's upper limb to 200mmHg for 5 minutes, then reduce the pressure to 0mmHg for 5 minutes, repeating this process for a total of 3 cycles. On the second day, perform a routine partial nephrectomy

Experimental : Ischemic preconditioning

NO ischemic preconditioning PROCEDURE

Routine partial nephrectomy

Comparator : No ischemic preconditioning

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who are scheduled to undergo partial nephrectomy, with no specific surgical procedure limitation, including laparoscopic surgery, robot-assisted surgery, and open surgery
• Aged 18 to 80
• Possess good organ function status: sufficient organ function (based on the normal values of the clinical trial center)
• Blood routine test: WBC≥3.5×10\^9/L, absolute neutrophil count ≥1.5×10\^9/L, PLT≥75.0×10\^9/L, HGB≥80g/L;
• Liver function: Total bilirubin ≤1.5×upper limit of normal (ULN), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5×ULN;

You may not qualify if:

• The anesthesiologist assesses that the patient cannot tolerate general anesthesia surgery
• Individuals with severe cardiovascular and cerebrovascular diseases, uncontrolled hypertension, and diabetes
• Estimated glomerular filtration rate (eGFR) \< 30 ml/min/1.73m²
• Horseshoe kidney
• Solitary kidney
• Pregnant women

Sponsors & Collaborators

• Sun Yat-sen University: lead

Study Sites (1)

651 Dongfeng Road East, Yuexiu District, Guangzhou, P.R. China Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, 510000, China

Location

MeSH Terms

Conditions

Carcinoma, Renal Cell; Acute Kidney Injury

Interventions

Ischemic Preconditioning

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Kidney Neoplasms; Urologic Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Kidney Diseases; Urologic Diseases; Male Urogenital Diseases; Renal Insufficiency

Intervention Hierarchy (Ancestors)

Therapeutics; Investigative Techniques

Study Officials

• Fangjian Zhou, professor

  Sun Yat-sen University Cancer Center (SYSUCC)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Fangjian Zhou, professor

CONTACT

020-87343865; zhoufj@sysucc.org.cn

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Model Details: The study cohort was randomly divided into two groups. One group received remote ischemic preconditioning one day before partial nephrectomy, while the other group underwent partial nephrectomy directly. The degree of acute renal injury on the operated side was compared between the two groups

Study Record Dates

• First Submitted: March 15, 2026
• First Posted: March 27, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: March 27, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)