The Impact of Ischemic Preconditioning on Exercise Performance and Physiological Function

NCT07146399 | Completed

• 1 other identifier: 2023LCLL-81
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Ischemic Preconditioning has been confirmed to prevent long-term ischemic damage to tissues, among which the improvement of autonomic nerve system function may be one of its mechanisms of action. In recent years, IPC has gradually been applied to enhance athletic performance and accelerate postexercise recovery; however, there has been limited research on the effects of IPC on ANS function and competitive condition before and after exercise. This study investigated the effects of IPC on ANS function before and after sport-specific testing in taekwondo athletes. The objectives of our study are (1) to investigate the impact of IPC on two indicators of autonomic nervous function-HRV and HRR-and (2) to reveal the coordinating effect of IPC on the sympathetic and parasympathetic nervous systems during the warm-up phase and after specific testing in taekwondo athletes. The investigators hypothesize that IPC enhances sympathetic drive during the warm-up phase and rapidly activates the parasympathetic nervous system postexercise, which is accompanied by improvements in the athletes' competitive condition.

Conditions

Ischemic Preconditioning; Autonomic Nervous System (ANS) Functioning and Mood State

Keywords

Ischemic preconditioning; Autonomic nervous system; Heart rate variability; Heart rate recovery

Outcome Measures

Primary Outcomes (4)

• Taekwondo-specific sports performance test.

  The specialized athletic ability in Taekwondo is measured by the number of kicks performed during the test.

  Five minutes after the intervention, a standard warm-up lasting 10 minutes is conducted. Following the warm-up, a rest period of 5 minutes is observed. Subsequently, three sets of specialized sports performance tests are administered, with each set lasti

• Heart rate variability

  Used to measure the autonomic nervous function of taekwondo athletes.

  The measurement time points were as follows: heart rate variability was assessed in the resting state upon participants' arrival at the testing site, after a warm-up, and following the sport-specific performance test.

• Heart rate recovery

  Used to measure the autonomic nervous function of taekwondo athletes.

  The measurement time points were established as follows: heart rate recovery was assessed for 1 minute during the intervals of each test group. Additionally, heart rate recovery was recorded at both 1 minute and 5 minutes following the completion of thre

• Blood lactate

  Used to measure the intensity and metabolic adaptations during the testing process of taekwondo athletes.

  Blood lactate measurements were taken at several key time points during the study: upon participants' arrival at the test site while they were in a quiet state; at the 3rd minute following the conclusion of the intervention; prior to the commencement of

Study Arms (2)

IPC Trial

EXPERIMENTAL

220 mmHg

Procedure: Ischemic Preconditioning

SHAM Trial

PLACEBO COMPARATOR

20 mmHg

Procedure: Sham (No Treatment)

Interventions

Ischemic Preconditioning PROCEDURE

Compression cuff width: 10CM; Compression duration: 5min/5min (ischemia/reperfusion) \*4. 220 mmHg

IPC Trial

Sham (No Treatment) PROCEDURE

Compression cuff width: 10CM; Compression duration: 5min/5min (compression/relaxation) \*4. 20 mmHg

SHAM Trial

Eligibility Criteria

• Age: 18 Years - 22 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Taekwondo athletes with a national ranking of level two or higher, including those placed in the top three at the Provincial Professional Taekwondo Championship (combat) and the top eight at the National Professional Taekwondo Championship (combat);
• adult males aged 18 years or older;
• regular participation in specialized Taekwondo training for the past three months.
• All the subjects were from the same team.

You may not qualify if:

• consumption of alcohol or caffeine within 24 hours prior to the experiment;
• engagement in strenuous physical activity within 24 hours before the experiment;
• presence of acute or chronic diseases, including cardiovascular diseases, anxiety disorders, and metabolic diseases;
• use of creatine supplements

Sponsors & Collaborators

• Ziyue Ou: lead
• Guangzhou Sport University: collaborator

Study Sites (1)

Guangzhou Sport University

Guangzhou, Guangdong, 510500, China

Location

Related Publications (4)

• Tsutsui H, Tanaka R, Yamagata M, Yukimura T, Ohkita M, Matsumura Y. Protective effect of ischemic preconditioning on ischemia/reperfusion-induced acute kidney injury through sympathetic nervous system in rats. Eur J Pharmacol. 2013 Oct 15;718(1-3):206-12. doi: 10.1016/j.ejphar.2013.08.032. Epub 2013 Sep 12.

  PMID: 24036256 BACKGROUND

• Lopes TR, Sabino-Carvalho JL, Ferreira THN, Succi JE, Silva AC, Silva BM. Effect of Ischemic Preconditioning on the Recovery of Cardiac Autonomic Control From Repeated Sprint Exercise. Front Physiol. 2018 Oct 26;9:1465. doi: 10.3389/fphys.2018.01465. eCollection 2018.

  PMID: 30416451 BACKGROUND

• Noronha Osorio D, Viana-Soares R, Marto JP, Mendonca MD, Silva HP, Quaresma C, Viana-Baptista M, Gamboa H, Vieira HLA. Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment. BMC Cardiovasc Disord. 2019 Sep 9;19(1):211. doi: 10.1186/s12872-019-1181-5.

  PMID: 31500561 BACKGROUND

• Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986 Nov;74(5):1124-36. doi: 10.1161/01.cir.74.5.1124.

  PMID: 3769170 BACKGROUND

MeSH Terms

Interventions

Ischemic Preconditioning; salicylhydroxamic acid

Intervention Hierarchy (Ancestors)

Therapeutics; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Sponsor-Investigator

Study Record Dates

• First Submitted: August 14, 2025
• First Posted: August 28, 2025
• Study Start: December 31, 2023
• Primary Completion: February 7, 2024
• Study Completion: February 7, 2024
• Last Updated: August 28, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)