NCT07461090

Brief Summary

To evaluate and compare clinical effectiveness (operative time, blood loss, hospital stay, complications and etc) and cost analysis' between laparoscopic nephrectomy and open nephrectomy .

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
8mo left

Started Feb 2026

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress30%
Feb 2026Feb 2027

Study Start

First participant enrolled

February 1, 2026

Completed
18 days until next milestone

First Submitted

Initial submission to the registry

February 19, 2026

Completed
19 days until next milestone

First Posted

Study publicly available on registry

March 10, 2026

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2027

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2027

Last Updated

March 11, 2026

Status Verified

March 1, 2026

Enrollment Period

11 months

First QC Date

February 19, 2026

Last Update Submit

March 9, 2026

Conditions

Nonfunctioning KidneyRenal Cell Carcinoma (RCC)

Keywords

Clinical effectiveness of laparoscopic nephrectomyCost analysis of laparoscopic nephrectomy

Outcome Measures

Primary Outcomes (1)

  • Length of hospital stay (LOS).

    Number of calendar days from date of index surgery to date of discharge .

    30 days post operative

Secondary Outcomes (1)

  • clinical effectiveness

    Post operative 30 days.

Study Arms (2)

open nephrectomy

ACTIVE COMPARATOR

Length of hospital stay (LOS) , post operative rehabilitation and cost analysis

Procedure: open or laparoscopic nephrectomy

laparoscopic nephrectomy

ACTIVE COMPARATOR

Length of hospital stay (LOS) , post operative rehabilitation and cost analysis

Procedure: open or laparoscopic nephrectomy

Interventions

open or laparoscopic nephrectomyPROCEDURE

compare post operative recovery , estimated blood loss and cost analysis between open and laparosopic nephrectomy.

laparoscopic nephrectomyopen nephrectomy

Eligibility Criteria

Age1 Year+
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • American Society of Anesthesiology score 1-3.
  • Indication for :
  • Simple total nephrectomy or hemi nephrectomy: benign chronic inflammatory non-functioning kidney
  • Partial nephrectomy: localized renal mass ≤7 cm suitable for nephron-sparing surgery.
  • Radical nephrectomy or Radical nephrouretrectomy with bladder cuff: localized renal tumor requiring complete nephrectomy without major vascular invasion.
  • Patient deemed fit for general anesthesia and surgery.
  • Patient provides written informed consent.

You may not qualify if:

  • emergency surgery, dialysis-dependent patients, planned hybrid procedures.
  • Patients with incomplete data
  • Patients with metastatic disease at presentation.
  • Prior extensive ipsilateral retroperitoneal surgery or severe adhesions precluding Laparoscopy.
  • Need for concomitant major procedures (eg, large bowel resection) at index operation.
  • Locally advanced tumor with obvious major vascular involvement requiring complex vascular reconstruction.
  • Uncorrected coagulopathy.
  • Pregnancy or Obese patient (BMI \> 40)
  • Inability to provide informed consent or comply with follow-up.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Menoufia Faculty of Medicine

Shibīn al Kawm, Shebin Elkom, 32111, Egypt

RECRUITING

MeSH Terms

Conditions

Carcinoma, Renal Cell

Condition Hierarchy (Ancestors)

AdenocarcinomaCarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeoplasmsKidney NeoplasmsUrologic NeoplasmsUrogenital NeoplasmsNeoplasms by SiteFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesKidney DiseasesUrologic DiseasesMale Urogenital Diseases

Central Study Contacts

Haitham Badr Elnaggar

CONTACT

01003247485naggarheso@gmail.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: To evaluate and compare clinical effectiveness (operative time, blood loss, hospital stay, complications and etc) and cost analysis between laparoscopic nephrectomy and open nephrectomy . randomized, controlled parallel-group clinical trials comparing peri-operative (pre-, intra-, and postoperative) assessments and cost outcomes of laparoscopic nephrectomy versus open nephrectomy.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr

Study Record Dates

First Submitted

February 19, 2026

First Posted

March 10, 2026

Study Start

February 1, 2026

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

February 1, 2027

Last Updated

March 11, 2026

Record last verified: 2026-03

Locations

EG(1)