URINARY INCONTINENCE AND PELVIC FLOOR MUSCLE ACTIVITY IN MULTIPLE SCLEROSIS

NCT07489794 | Recruiting

• 1 other identifier: MS-UI-PFM-2026
• Study Type: observational
• Target: 47
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the relationship between urinary incontinence severity and surface electromyography (EMG) findings in women with multiple sclerosis. It will also examine the association of urinary incontinence with disability, quality of life, physical activity, and fatigue.

Conditions

Multiple Sclerosis; Urinary Incontinence (UI)

Keywords

multiple sclerosis; urinary incontinence; Electromyography; Fatigue; Physical Activity

Outcome Measures

Primary Outcomes (1)

• Pelvic floor muscle activity with surface EMG

  Evaluated using biofeedback-assisted surface EMG. Metrics recorded include mean EMG activity during contraction and rest phases, standard deviation of EMG activity, peak and minimum EMG values, contraction onset, and relaxation times

  baseline

Secondary Outcomes (4)

• International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF)

  baseline

• Incontinence Impact Questionnaire (IIQ-7)

  baseline

• International Physical Activity Questionnaire (IPAQ)

  baseline

• Fatigue Severity Scale (FSS)

  baseline

Study Arms (1)

Observational Group

Participants will be observed for EMG activity, fatigue, physical activity, and urinary incontinence symptoms.

Eligibility Criteria

• Age: 30 Years - 50 Years
• Gender Eligibility Details: Study limited to biological females due to pelvic floor muscle assessment
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study will include female patients with multiple sclerosis (MS) aged 30-50 years, diagnosed according to the 2017 revised McDonald criteria, who experience urinary incontinence symptoms according to the International Continence Society (ICS) definition and have an EDSS score below 6.5. Participants must be able to communicate effectively. Patients who do not provide consent, have had a medication change within the last 6 months, are pregnant, have had a vaginal or cesarean delivery within the last 6 months, have pelvic organ prolapse, or have a urinary tract infection will be excluded.

You may qualify if:

• Diagnosis of multiple sclerosis (MS) according to the 2017 revised McDonald criteria.
• Female patients aged 30-50 years (age range with higher prevalence of urinary incontinence in MS).
• Experiencing urinary incontinence (UI) symptoms according to the International Continence Society (ICS) definition.
• EDSS (Expanded Disability Status Scale) score below 6.5.
• Patients with no communication difficulties. -

You may not qualify if:

• MS patients who do not provide consent to participate in the study.
• MS patients who have had a medication change within the last 6 months.
• Pregnant MS patients.
• History of vaginal or cesarean delivery within the last 6 months.
• Pelvic organ prolapse.
• Urinary tract infection

Sponsors & Collaborators

• Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization: lead

Study Sites (1)

Istanbul, Prof. Dr. Cemil Taşçıoğlu City Hospital, Turkey

Istanbul, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Multiple Sclerosis; Urinary Incontinence; Fatigue; Motor Activity

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Urination Disorders; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Lower Urinary Tract Symptoms; Urological Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Central Study Contacts

Büşra Aydın Erkılıç, MSc

CONTACT

905062214052; bsrr.aydinn@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: physiotherapist

Study Record Dates

• First Submitted: March 18, 2026
• First Posted: March 24, 2026
• Study Start: March 9, 2026
• Primary Completion (Estimated): September 20, 2026
• Study Completion (Estimated): October 30, 2026
• Last Updated: March 24, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)