Multiple Sclerosis, Sarcopenia and Respiration

NCT07152015 | Completed

• 1 other identifier: sar123
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to evaluate the relationship between respiratory function and sarcopenia in people with multiple sclerosis. The main questions it aims to answer are: Is there a relationship between muscle structure and respiratory muscle strength/pulmonary function in MS patients? Undergo a single session of respiratory muscle strength measurement (e.g., maximal inspiratory pressure \[MIP\], maximal expiratory pressure \[MEP\]) Perform spirometry to assess pulmonary function

Conditions

Multiple Sclerosis

Keywords

multiple sclerosis; sarcopenia; inspiratory muscle strength

Outcome Measures

Primary Outcomes (5)

• Forced Vital Capacity

  FVC, defined as the total volume of air that can be forcibly exhaled after full inspiration, will be recorded with spirometry using the Cosmed Pony FX device, following ATS guidelines.

  1 day (The evaluation will be done one-time)

• Forced Expiratory Volume in 1 second (FEV1)

  FEV1, spirometric evaluation of the maximum volume of air exhaled in the first second of a forced breath, will be measured using the Cosmed Pony FX device (Rome, Italy) in accordance with ATS standards.

  1 day (The evaluation will be done one-time)

• FEV1/FVC Ratio (%)

  The ratio of FEV1 to FVC (FEV1/FVC) will be obtained as an index of airflow limitation. This ratio will be calculated from spirometry values measured with the Cosmed Pony FX device under ATS standards.

  1 day (The evaluation will be done one-time)

• Maximal Inspiratory Pressure

  MIP, reflecting inspiratory muscle strength, will be assessed through maximal inspiratory efforts against a closed airway, using the Cosmed Pony FX device according to ATS recommendations.

  1 day (The evaluation will be done one-time)

• Maximal Expiratory Pressure

  MEP, representing expiratory muscle strength, will be determined by maximal expiratory efforts against a closed airway. Measurements will be obtained with the Cosmed Pony FX device (Rome, Italy) according to ATS standards

  1 day (The evaluation will be done one-time)

Secondary Outcomes (2)

• and grip strength measurement

  1 day (The evaluation will be done one-time)

• Skeletal Muscle Index (SMI, kg/m²)

  1 day (The evaluation will be done one-time)

Study Arms (2)

Sarcopenic MS

Nonsarcopenic MS

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patient with Multiple Sclerosis Disease

You may qualify if:

• Being diagnosed with MS by a neurologist
• Being diagnosed with Sarcopenia
• No history of attacks in the last 3 months
• Able to walk with and without support (EDSS\<6.5)

You may not qualify if:

• Having concomitant lung and heart disease
• Mini Mental score below 24
• Being in pregnancy

Sponsors & Collaborators

• Uskudar University: lead

Study Sites (1)

Uskudar University

Istanbul, Turkey (Türkiye)

Location

Related Publications (1)

• Sawaya Y, Shiba T, Ishizaka M, Hirose T, Sato R, Kubo A, Urano T. Sarcopenia is not associated with inspiratory muscle strength but with expiratory muscle strength among older adults requiring long-term care/support. PeerJ. 2022 Feb 17;10:e12958. doi: 10.7717/peerj.12958. eCollection 2022.

  PMID: 35194529 BACKGROUND

MeSH Terms

Conditions

Multiple Sclerosis; Sarcopenia

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Officials

• Tuba Kolaylı Çerezci, PhD(c)

  Uskudar University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: August 18, 2025
• First Posted: September 3, 2025
• Study Start: September 5, 2025
• Primary Completion: September 15, 2025
• Study Completion: September 20, 2025
• Last Updated: April 1, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)