NCT07484516

Brief Summary

This study is intended to find the effects of Eccentric exercises along with muscle energy technique (MET) on pain, functional disability, range of motion and grip strength in Lateral Epicondylitis. For this trial, participants will be enrolled with their consent after assessing on basis of inclusion \& exclusion criteria from orthopedic workshop, Jinnah post graduate medical center Karachi. Total of 66 participants will be recruited and will be equally randomized into three groups consisting of 22 participants in each group. They would recruit into either Eccentric exercise (EE) along with MET group (group A) or MET group (group B) or EE group (group C). Participants will be allocated to intervention by sealed envelope method and will undergo a total of 8 treatment sessions within 2 weeks. Baseline assessment will carry out before treatment on 1st session and follow-up assessment on 8th session after treatment through tool named as Numeric Pain-Rating Scale (NPRS), Patient Rated Tennis Elbow Evaluation (PRTEE), Goniometer and Handheld dynamometer.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
66

participants targeted

Target at P50-P75 for not_applicable

Timeline
1mo left

Started Mar 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress70%
Mar 2026Aug 2026

Study Start

First participant enrolled

March 1, 2026

Completed
15 days until next milestone

First Submitted

Initial submission to the registry

March 16, 2026

Completed
4 days until next milestone

First Posted

Study publicly available on registry

March 20, 2026

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2026

Last Updated

March 20, 2026

Status Verified

March 1, 2026

Enrollment Period

5 months

First QC Date

March 16, 2026

Last Update Submit

March 16, 2026

Conditions

Lateral Epicondylitis

Keywords

lateral epicondylitisMuscle energy techniqueeccentric exercise

Outcome Measures

Primary Outcomes (1)

  • Numeric Pain Rating Scale

    Changes from Baseline pain values will be taken with the help of Numeric Pain Rating Scale measures level of pain. Scoring is done by selecting a point from zero to ten as the current level of pain. Zero means minimum pain and 10 denotes maximum pain.

    2nd Week

Secondary Outcomes (3)

  • Patient Rated Tennis Elbow Evaluation Scale

    2nd Week

  • Pain-free grip strength

    2nd Week

  • Range of Motion

    2nd Week

Study Arms (3)

Group A: Eccentric exercise along with muscle energy technique

EXPERIMENTAL

Pulsed Ultrasound for 10 minutes, eccentric exercise and muscle energy technique for 8 sessions within 2 weeks.

Other: Eccentric exercise and muscle energy technique

Group B: Muscle energy technique

EXPERIMENTAL

Pulsed Ultrasound for 10 minutes and muscle energy technique for 8 sessions within 2 weeks.

Other: Muscle energy technique

Group C: Eccentric exercise

EXPERIMENTAL

Pulsed Ultrasound for 10 minutes and eccentric exercise for 8 sessions within 2 weeks.

Other: Eccentric Exercise

Interventions

Muscle energy techniqueOTHER

For MET, patient's affected forearm will be stabilized with elbow 90 degrees flexed. The mobilizing hand will hold the wrist and move into the supination until resistance or discomfort is detected. Then the patient will gently pronate against resistance for 5 seconds. Then with a relaxation phase of 5 seconds the therapist will stretch gently to re-position the forearm into a new supination barrier or until resistance will be met for several seconds (20-30 sec). No of each isometric contraction in a single session will be 5 times. Pulsed mode ultrasound therapy will be given at frequency of I MHz for 10 minutes.

Group B: Muscle energy technique
Eccentric ExerciseOTHER

For Eccentric Exercise Patient will be in sitting position with full elbow extension, forearm pronation, and maximum wrist extension. Then the patient will be asked to slowly lower wrist with 0.5 or 1 kg weight into flexion for a count of 30. Then they will use the non-affected hand to return the wrist to maximum extension again. 3 sets of 10 repetitions / session and 1 minute rest/set. Pulsed mode ultrasound therapy will be given at frequency of I MHz for 10 minutes.

Group C: Eccentric exercise
Eccentric exercise and muscle energy techniqueOTHER

For Eccentric Exercise, patient be in sitting position with full elbow extension, forearm pronation, and maximum wrist extension. The patient will be asked to slowly lower the wrist with 0.5 or 1 kg weight into flexion for a count of 30. Non-affected hand will be used to return the wrist to maximum extension again. 3 sets of 10 repetitions / session and 1 minute rest/set For MET, patient's affected forearm will be stabilized with 90 degrees flexed elbow. The mobilizing hand will hold the wrist and move into the supination until resistance or discomfort is detected. Then the patient will gently pronate against resistance for 5 seconds. Then with a relaxation phase of 5 seconds the therapist will stretch gently to re-position the forearm into a new supination barrier or until resistance will be met for several seconds (20-30 sec). No. of each isometric contraction in a single session will be 5 times. Pulsed mode ultrasound therapy will be given at frequency of I MHz for 10 minutes.

Group A: Eccentric exercise along with muscle energy technique

Eligibility Criteria

Age20 Years - 50 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Subacute \& chronic patients
  • Participants diagnosed with lateral epicondylitis based on
  • Pain local to the lateral epicondyle reproduced with palpation.
  • Positive Mill's test and Cozen's test and/or Maudsley's test
  • Patient's willingness in participation in this study.

You may not qualify if:

  • Any recent history of fracture /surgery
  • Acute patients
  • Peripheral nerve entrapment like radial tunnel syndrome
  • Cervical radiculopathy
  • Instability of joint
  • Corticosteroid injection within 3- 6 months
  • Neurological impairments
  • Cardiovascular diseases
  • Osteoporosis
  • Local infection
  • Malignancy
  • Congenital /structural anomalies
  • Systemic illness affecting joint function like Rheumatoid arthritis, psoriatic arthritis etc.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Jinnah Post Graduate Medical Center (Orthopedic Workshop)

Karachi, Sindh, 75510, Pakistan

Location

MeSH Terms

Conditions

Tennis Elbow

Condition Hierarchy (Ancestors)

Elbow TendinopathyTendinopathyMuscular DiseasesMusculoskeletal DiseasesElbow InjuriesArm InjuriesWounds and InjuriesTendon Injuries

Study Officials

  • Dr. Muhammad Affan Iqbal, PT, PhD*

    Riphah International university, Islamabad

    PRINCIPAL INVESTIGATOR

  • Dr. Saba Ramzan, PT, MSPT

    Riphah International University, Islamabad

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Dr. Imran Amjad, PT, PhD

CONTACT

03324390125imran.amjad@riphah.edu.pk

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 16, 2026

First Posted

March 20, 2026

Study Start

March 1, 2026

Primary Completion (Estimated)

August 1, 2026

Study Completion (Estimated)

August 1, 2026

Last Updated

March 20, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

Locations

PA(1)