NCT07424794

Brief Summary

This randomized controlled trial aims to compare the effectiveness of Mobilization with Movement (MWM) and Cyriax techniques in athletes diagnosed with lateral epicondylitis (tennis elbow). Lateral epicondylitis commonly causes pain, reduced grip strength, and impaired proprioception, particularly in racquet and throwing sports players. A total of 56 participants aged 25-40 years with symptoms of less than three months will be randomly assigned to either the MWM group or the Cyriax group. Both groups will receive treatment five times per week for four weeks. Outcomes including elbow proprioception (Joint Position Sense test), pain and functional disability (Patient-Rated Tennis Elbow Evaluation), and grip strength (Handheld Dynamometer) will be assessed at baseline, at 2 weeks, and at 4 weeks. The study aims to determine which treatment method provides superior improvement in pain reduction, functional recovery, and proprioceptive enhancement.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
56

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Feb 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 14, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 20, 2026

Completed
5 days until next milestone

Study Start

First participant enrolled

February 25, 2026

Completed
29 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 26, 2026

Completed
1 day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 27, 2026

Completed
Last Updated

June 10, 2026

Status Verified

February 1, 2026

Enrollment Period

29 days

First QC Date

February 14, 2026

Last Update Submit

June 6, 2026

Conditions

Keywords

Mobilization with Movement (MWM)Cyriax TechniqueDeep Transverse Friction MassageMill's Manipulation

Outcome Measures

Primary Outcomes (1)

  • Elbow Proprioception Assessed by Joint Position Sense (JPS) Test

    Elbow proprioception will be assessed using the Joint Position Sense (JPS) test. Participants will be asked to actively reproduce a predetermined elbow flexion angle (e.g., 90°) with their eyes closed. The difference in degrees between the target angle and the reproduced angle (absolute error) will be recorded. Lower absolute error values indicate better proprioceptive accuracy. Three trials will be performed, and the average error will be calculated for analysis.

    Baseline, Week 2, and Week 4

Study Arms (2)

interventional group Mobilization with Movement (MWM)

EXPERIMENTAL

Participants in this group will receive Mobilization with Movement (MWM) techniques applied to the elbow joint along with progressive wrist extensor strengthening, proprioceptive training, and sport-specific functional exercises. Treatment will be administered five times per week for four weeks (total 16 sessions). Ice therapy may be applied post-session as needed. Standardized baseline education, stretching, and isometric exercises will be provided before the intervention phase.

Behavioral: MWM

interventional group Cyriax Technique

EXPERIMENTAL

Participants in this group will receive Cyriax techniques including deep transverse friction massage (DTFM) and Mill's manipulation, combined with progressive wrist extensor strengthening, grip exercises, proprioceptive drills, and sport-specific activities. Treatment will be delivered five times per week for four weeks (total 16 sessions). Ice therapy may be applied post-session. Standardized baseline education, stretching, and light isometric exercises will be provided prior to the intervention phase.

Behavioral: Cyriax techniques

Interventions

MWMBEHAVIORAL

Mobilization with Movement (MWM) group will receive interventions five times per week. In the first week, the primary focus is on applying lateral glide mobilization to the elbow joint. The patient performs pain-free gripping or wrist extension activities while the therapist provides a sustained lateral glide, enhancing joint mechanics and reducing pain. This is complemented by isometric strengthening exercises for the wrist extensors (3 sets of 10 repetitions with 5-second holds) and proprioceptive neuromuscular facilitation (PNF) rhythmic stabilization techniques to begin improving joint position sense. Ice therapy may be used post-session to control inflammation. In the second week, the MWM technique is continued with increased repetitions and resistance based on patient tolerance. Eccentric wrist extensor strengthening using resistance bands is introduced, performed in 3 sets of 10 repetitions. Light sport-specific tasks such as racquet swings with minimal resistance are incorporat

interventional group Mobilization with Movement (MWM)

Participants in the cyriax techniques group also receive treatment five times per week over four weeks. In the first week, the primary intervention is deep transverse friction massage (DTFM), applied for 10-15 minutes over the common extensor origin to break down adhesions and reduce localized pain. Isometric strengthening exercises for the wrist extensors are introduced with 3 sets of 10 repetitions, each held for 5 seconds. Ice therapy follows each session to reduce any post-treatment inflammation. Mill's manipulation is not used in the first week to allow tissue acclimatization to DTFM. In the second week, DTFM is continued on alternate days. Mill's manipulation, a high-velocity, low-amplitude technique that stretches the affected tendon, is introduced once per week immediately following DTFM. Resistance ball exercises are added for grip strengthening, encouraging the return of functional muscle performance. Isometric exercises are continued to maintain muscle recruitment without ag

interventional group Cyriax Technique

Eligibility Criteria

Age25 Years - 40 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Both male and female population including sports persons(only throw ball players e.g racquet players)
  • Population with age range of 25 - 40 years.
  • Include only clinically diagnosed lateral epicondylitis patients
  • Patients with proprioception impairments in affected limb
  • Symptoms duration less than 3 months, not longer than 3 months

You may not qualify if:

  • Other Elbow Pathologies such as cubital tunnel syndrome, radial tunnel syndrome, or osteoarthritis of the elbow.
  • Recent Corticosteroid Injections in the affected elbow within the past 3 months.
  • Neurological conditions affecting proprioception (e.g., multiple sclerosis, peripheral neuropathy).
  • Autoimmune diseases, diabetes, or connective tissue disorders that may influence healing or proprioception.
  • History of surgical intervention in the affected upper limb.(Karthikeyan) Pregnant or planning to become pregnant during the study period

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Lahore Teaching Hospital, Lahore

Lahore, Punjab Province, 54000, Pakistan

Location

MeSH Terms

Conditions

Tennis Elbow

Condition Hierarchy (Ancestors)

Elbow TendinopathyTendinopathyMuscular DiseasesMusculoskeletal DiseasesElbow InjuriesArm InjuriesWounds and InjuriesTendon Injuries

Study Officials

  • Mohammad Affan, MSPTN

    The University of Lahore, Lahore

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
principal investigator

Study Record Dates

First Submitted

February 14, 2026

First Posted

February 20, 2026

Study Start

February 25, 2026

Primary Completion

March 26, 2026

Study Completion

March 27, 2026

Last Updated

June 10, 2026

Record last verified: 2026-02

Locations