Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)

NCT07451873 | Recruiting

• 1 other identifier: R1-10842/2025
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective of the project is to increase the excellence and interdisciplinarity of scientific work at MEFOS by connecting researchers from different scientific fields, improving conditions and resources for scientific work, and increasing international cooperation, in line with strategic objective 1: raising scientific excellence. The results of the project could provide pathophysiological insight into the development and maintenance of endothelial dysfunction in CVD, as well as identify new biomarkers for CVD.

Conditions

Coronary Heart Disease

Keywords

Glycocalyx; Inflammation; Oxidative stress; Endothelium; Coronary Artery Disease; Myocardial Revascularization

Outcome Measures

Primary Outcomes (1)

• Endothelial glycocalyx

  Measurement of the thickness of endothelial glycocalyx in coronary heart disease patients before and after bypass surgery - measured by Glycocheck

  Perioperative/Periprocedural

Secondary Outcomes (6)

• Bypass graft sample reactivity

  Baseline, at one time point

• Endothelial glycocalyx soluble markers

  Perioperative/Periprocedural

• Intracellular oxidative stress production

  Perioperative/Periprocedural

• Inflammation

  Perioperative/Periprocedural

• Antioxidant capacity

  Perioperative/Periprocedural

Other Outcomes (5)

• Blood pressure

  Perioperative/Periprocedural

• Heart rate

  Perioperative/Periprocedural

• Body Mass Index

  Perioperative/Periprocedural

Study Arms (1)

Coronary Heart Disease (CHD) patients

Adult patients of both sexes over 18 years of age, undergoing elective coronary artery bypass grafting (CABG) and who provided written informed consent

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients undergoing elective coronary artery bypass grafting (CABG)

You may qualify if:

• adult patients of both sexes over 18 years of age
• Caucasian
• undergoing elective coronary artery bypass grafting (CABG)
• provided written informed consent

You may not qualify if:

• emergency surgery
• sepsis or severe systemic inflammation before surgery
• severe renal or hepatic insufficiency
• immunosuppression
• serious comorbidities (e.g., active cancer)
• therapies that could affect oxidative stress (e.g., high doses of corticosteroids)

Sponsors & Collaborators

• Josip Juraj Strossmayer University of Osijek: lead

Study Sites (1)

Osijek University Hospital

Osijek, 31000, Croatia

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

serum, plasma, peripheral blood mononuclear cells (PBMC)

MeSH Terms

Conditions

Coronary Disease; Inflammation; Coronary Artery Disease

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Arteriosclerosis; Arterial Occlusive Diseases

Central Study Contacts

Ines Drenjančević, MD, PhD

CONTACT

+385912241406; ines.drenjancevic@mefos.hr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Department of Physiology and Immunology Faculty of Medicine Osijek

Study Record Dates

• First Submitted: February 17, 2026
• First Posted: March 5, 2026
• Study Start: October 1, 2025
• Primary Completion (Estimated): September 30, 2029
• Study Completion (Estimated): September 30, 2029
• Last Updated: March 9, 2026

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

CR (1)