Lower-Limb Muscle Mass and Cardiovascular and Muscular Performance in Males and Females

NCT07440615 | Recruiting

• 1 other identifier: E-87914409-050.04-87583
• Study Type: interventional
• Target: 235
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study will be to examine the relationship between leg muscle mass and muscle strength, aerobic capacity, anaerobic power, and jumping performance in young adults. In addition, these physical performance measures will be compared between male and female participants. Recreationally active young adults will be recruited to participate in the study. Body weight and leg muscle mass will be assessed using a body composition analyzer. Participants will perform isokinetic and isometric leg strength tests, an aerobic fitness test (VO₂max), an anaerobic power test (Wingate), and a countermovement jump (CMJ) test. This study aims to improve the understanding of the effects of leg muscle mass on physical performance and to identify possible differences between males and females. The findings are expected to contribute to exercise prescription, performance assessment, and future research in sports and health sciences.

Conditions

Physical Performance; Leg Muscle Mass; Aerobic Capacity; Anaerobic Power; Jumping Performance in Young Adults; Muscle Strength

Keywords

lean mass; isokinetic; isometric; aerobic capacity; force

Outcome Measures

Primary Outcomes (6)

• Leg Muscle Mass-Related Physical Performance Measures

  Measurement tool: Bioelectrical Impedance Analyzer (InBody 270, Biospace Co., South Korea) Description: Segmental lower-limb muscle mass (kg) measured using multi-frequency bioelectrical impedance analysis. Unit: kg Time Frame: Baseline (single assessment)

  Baseline

• Muscle Isokinetic Strength

  Measurement tool: Isokinetic dynamometer (Humac Norm, Computer Sports Medicine Inc., USA) Description: Peak torque of dominant leg knee flexors and extensors measured at 60°·s-¹ and normalized to body weight. Unit: Nm·kg-¹ Time Frame: Baseline

  Baseline

• Anaerobic Power

  Measurement tool: Wingate Anaerobic Test performed on cycle ergometer (Wattbike WPM Model B, UK) Description: Relative peak anaerobic power calculated during 30-s Wingate test and normalized to body weight. Unit: W·kg-¹ Time Frame: Baseline

  Baseline

• Countremovement Jump

  Measurement tool: SmartJump contact mat system (Fusion Sport, Queensland, Australia) Description: Vertical jump height measured during the Countermovement Jump test. Jump height is calculated automatically from flight time using the SmartJump performance measurement system. Scale description: Countermovement Jump Height (centimeters). Typical physiological range in healthy young adults is approximately 10-60 cm. Interpretation: Higher values indicate better lower-body explosive performance. Unit: cm Time Frame: Baseline (up to 8 weeks)

  Baseline

• Aerobic Capacity

  Measurement tool: Breath-by-breath metabolic gas analyzer (Cosmed Quark CPET) during Bruce treadmill protocol Description: Maximal oxygen consumption determined according to standard VO₂max criteria. Unit: ml·kg-¹·min-¹ Time Frame: Baseline

  Baseline

• Muscle Isometric Strength

  Measurement tool: Leg dynamometer (Takei T.K.K. 5402, Takei Scientific Instruments, Japan) Description: Maximal voluntary isometric force normalized to body weight. Highest value of three trials recorded. Unit: kg·kg-¹ Time Frame: Baseline

  Baseline

Study Arms (1)

Young Adult Participants Healthy Recreationally Active Adults

EXPERIMENTAL

Male and Female Participant

Other: Physical Performance Assessment

Interventions

Physical Performance Assessment OTHER

Muscle Isokinetic Strength Testing, Leg Muscle Mass, and Aerobic and Anaerobic Performance Testing, Contermovement Jump

Young Adult Participants Healthy Recreationally Active Adults

Eligibility Criteria

• Age: 18 Years - 30 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• absent of lower body injuries that could impact testing;
• were moderately physically active
• did not ingest ergogenic aids or stimulant drugs for at least 6 months prior to the start of the study.

Sponsors & Collaborators

• Uludag University: lead

Study Sites (1)

Aeromedical Research and Training Center (ARTC)

Eskişehir, 26000, Turkey (Türkiye)

RECRUITING

Related Publications (9)

• Amaral JF, Alvim FC, Castro EA, Doimo LA, Silva MV, Novo Junior JM. Influence of aging on isometric muscle strength, fat-free mass and electromyographic signal power of the upper and lower limbs in women. Braz J Phys Ther. 2014 Mar-Apr;18(2):183-90. doi: 10.1590/s1413-35552012005000145. Epub 2014 Mar 19.

  PMID: 24676705 BACKGROUND

• Boraczynski M, Boraczynski T, Podstawski R, Wojcik Z, Gronek P. Relationships Between Measures of Functional and Isometric Lower Body Strength, Aerobic Capacity, Anaerobic Power, Sprint and Countermovement Jump Performance in Professional Soccer Players. J Hum Kinet. 2020 Oct 31;75:161-175. doi: 10.2478/hukin-2020-0045. eCollection 2020 Oct.

  PMID: 33312304 BACKGROUND

• Bullo V, Roma E, Gobbo S, Duregon F, Bergamo M, Bianchini G, Doria E, Cugusi L, Blasio AD, Bocalini DS, Ermolao A, Bergamin M. Lower Limb Strength Profile in Elderly with Different Pathologies: Comparisons with Healthy Subjects. Geriatrics (Basel). 2020 Oct 22;5(4):83. doi: 10.3390/geriatrics5040083.

  PMID: 33105620 BACKGROUND

• Comfort P, McMahon JJ, Lake JP, Ripley NJ, Triplett NT, Haff GG. Relative strength explains the differences in multi-joint rapid force production between sexes. PLoS One. 2024 Feb 15;19(2):e0296877. doi: 10.1371/journal.pone.0296877. eCollection 2024.

  PMID: 38359039 BACKGROUND

• Cuesta-Vargas A, Gonzalez-Sanchez M. Correlation between architectural variables and torque in the erector spinae muscle during maximal isometric contraction. J Sports Sci. 2014;32(19):1797-804. doi: 10.1080/02640414.2014.924054. Epub 2014 Jun 6.

  PMID: 24903060 BACKGROUND

• Driller MW, Argus CK, Shing CM. The reliability of a 30-s sprint test on the Wattbike cycle ergometer. Int J Sports Physiol Perform. 2013 Jul;8(4):379-83. doi: 10.1123/ijspp.8.4.379.

  PMID: 23863304 BACKGROUND

• Farinatti P, Castinheiras Neto AG, Amorim PR. Oxygen Consumption and Substrate Utilization During and After Resistance Exercises Performed with Different Muscle Mass. Int J Exerc Sci. 2016 Jan 15;9(1):77-88. doi: 10.70252/AKBM3973. eCollection 2016.

  PMID: 27293507 BACKGROUND

• Harris-Love MO, Benson K, Leasure E, Adams B, McIntosh V. The Influence of Upper and Lower Extremity Strength on Performance-Based Sarcopenia Assessment Tests. J Funct Morphol Kinesiol. 2018 Dec;3(4):53. doi: 10.3390/jfmk3040053. Epub 2018 Nov 3.

  PMID: 30533549 BACKGROUND

• Laffaye G, Wagner PP, Tombleson TI. Countermovement jump height: gender and sport-specific differences in the force-time variables. J Strength Cond Res. 2014 Apr;28(4):1096-105. doi: 10.1519/JSC.0b013e3182a1db03.

  PMID: 23838969 BACKGROUND

Central Study Contacts

Tuncay ALPARSLAN, Assoc.Prof.

CONTACT

Türkiye; tuncayalparslan@hotmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: January 5, 2026
• First Posted: February 27, 2026
• Study Start: February 20, 2026
• Primary Completion: June 5, 2026
• Study Completion (Estimated): August 15, 2026
• Last Updated: June 9, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)