Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.

NCT07438938 | Recruiting

• 1 other identifier: ONZ-2025-0418
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide. Despite constantly improving resuscitation techniques, the chances of survival remain limited. During cardiopulmonary resuscitation (CPR), a closure of the airway may occur, impeding ventilation. This phenomenon also complicates the interpretation of the end-tidal CO2 (ETCO2) in the capnogram. The extent to which airway closure occurs is quantified by the Airway Opening Index (AOI). This can be calculated from the capnogram and is seen as a measure of the quality of CPR applied as well as a possible indicator to predict the outcome of CPR. In this study, we analyse capnogram data from approximately 150 cases, collected during interventions for OHCA and logged in the Lazarus database (UZ Gent and AZORG) to answer three research questions below:

1. 1.What is the prevalence of AOI during CPR?
2. 2.Is there a correlation between AOI and return of spontaneous circulation (ROSC)?
3. 3.Does the application of positive end-expiratory pressure (PEEP) affect the AOI and ROSC?

Conditions

Cardiac Arrest (CA); Out-of-hospital Cardiac Arrest (OHCA); Resuscitated Sudden Cardiac Death

Keywords

capnography; airway closure

Outcome Measures

Primary Outcomes (1)

• ROSC

  Return-of-spontaneous circulation during initial resuscitation.

  Initial resuscitation (first day)

Study Arms (2)

ROSC

Patients with return-of-spontaneous circulation during initial resuscitation.

non-ROSC

Patients without return-of-spontaneous circulation during initial resuscitation.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This retrospective observational cohort study included adult patients who suffered an out-of-hospital cardiac arrest (OHCA) and were treated by the Mobile Emergency Team (MET) of Ghent University Hospital. All cases were registered in the Lazarus database, which prospectively collects prehospital CPR data including continuous capnography recordings.

You may qualify if:

• Adult (over 18 years old) patients with out-of-hospital cardiac arrest.
• Patients undergoing cardiopulmonary resuscitation (CPR).
• Patients who were intubated and had available capnogram recordings immediately after intubation.

You may not qualify if:

• Patients that were not intubated
• Patients that did not receive CPR following intubation
• Cases with a technical challenge with the ETCO₂ measurement (i.e., issues with waveform data of the capnogram.

Sponsors & Collaborators

• University Hospital, Ghent: lead

Study Sites (1)

Ghent University Hospital

Ghent, East-Flanders, B9000, Belgium

RECRUITING

MeSH Terms

Conditions

Heart Arrest; Out-of-Hospital Cardiac Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Central Study Contacts

Said Hachimi Idrissi, MD, PhD

CONTACT

0032 9 332 50 24; SAID.HACHIMIIDRISSI@ugent.be

Thomas Tackaert, MD

CONTACT

thomas.tackaert@ugent.be

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 14, 2025
• First Posted: February 27, 2026
• Study Start: October 1, 2022
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): January 1, 2027
• Last Updated: February 27, 2026

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)