NCT07834294

Brief Summary

During cardiopulmonary resuscitation (CPR), rescue breaths help move air into the lungs, but the amount of air delivered is rarely measured. This study examined whether the amount and rate of air delivered during CPR were related to the heart restarting its own circulation, called return of spontaneous circulation (ROSC).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Sep 2023

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 11, 2023

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 4, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 4, 2025

Completed
1.7 years until next milestone

First Submitted

Initial submission to the registry

September 9, 2026

Completed
13 days until next milestone

First Posted

Study publicly available on registry

September 22, 2026

Completed
Last Updated

September 22, 2026

Status Verified

September 1, 2026

Enrollment Period

1.3 years

First QC Date

September 9, 2026

Last Update Submit

September 16, 2026

Conditions

Cardiac Arrest (CA)

Outcome Measures

Primary Outcomes (1)

  • Number of Participants Who Achieved Return of Spontaneous Circulation (ROSC)

    ROSC status was obtained from the medical record for the monitored resuscitation event and recorded as a binary outcome (yes/no). The number and percentage of participants with documented ROSC will be reported.

    At the end of the monitored resuscitation event (Day 1).

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adults who experienced in-hospital cardiac arrest at one of three participating hospitals and received manual ventilation through a mask or advanced airway during cardiopulmonary resuscitation (CPR).

You may qualify if:

  • Adult subjects 18 years and older
  • Admitted to any area of the hospital, including the emergency department
  • Receiving manual ventilation by mask or artificial airway (laryngeal mask airway, endotracheal tube, or tracheostomy tube)
  • Cardiac arrest requiring CPR, including chest compressions

You may not qualify if:

  • anyone under 18 years of age

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Rush University Medical Center

Chicago, Illinois, 60612, United States

Location

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Study Officials

  • Jie Li, PhD

    Rush University Medical Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor; Program Director

Study Record Dates

First Submitted

September 9, 2026

First Posted

September 22, 2026

Study Start

September 11, 2023

Primary Completion

January 4, 2025

Study Completion

January 4, 2025

Last Updated

September 22, 2026

Record last verified: 2026-09

Data Sharing

IPD Sharing
Will not share

Locations

US(1)