A Study to See if an Energy Drink With Caffeine and Green Tea Increases Fat Burning When Exercising

NCT07434752 | Recruiting Phase 4

• 1 other identifier: GRIFEX
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to evaluate the influence of consuming a drink containing a combination of caffeine and green tea extracts on fat oxidation responses at rest, during and after a period of endurance type exercise.

Conditions

Exercise

Keywords

metabolism

Outcome Measures

Primary Outcomes (1)

• Fat oxidation as measured by indirect calorimetry

  Change from baseline to the end of the study period in Fat oxidation as measured by indirect calorimetry (metabolic cart); baseline (pre-drink), post-drink (pre-exercise), time sequence e.g., every 5-min during exercise, 10, 20 and 30-min post-exercise. Change from baseline \& total. Fat oxidation will be measured continuously throughout the exercise and the 30-min post-exercise window, to facilitate total, and any other temporal fat oxidation timepoints.

  Baseline to 30 mins post exercise

Secondary Outcomes (3)

• Carbohydrate oxidation; indirect calorimetry

  Baseline to 30 mins post exercise

• Respiratory exchange ratio; indirect calorimetry

  Baseline to 30 mins post exercise

• Exercise efficiency; indirect calorimetry

  Baseline to 30 mins post exercise

Other Outcomes (11)

• Tertiary: Compliance monitoring

  Baseline to end of study period (week 5)

• Tertiary: Adverse Event monitoring

  Baseline to end of study period (week 5)

• Tertiary: Perceived gastrointestinal (dis)comfort questionnaire

  Baseline to end of study (week 5)

Study Arms (2)

Active

EXPERIMENTAL

Two 355 mL cans of "XS Energy + BURN" drink containing caffeine and green tea extract.

Dietary Supplement: Active (Green tea and caffeine)

Placebo

OTHER

Two 355 mL cans of placebo drink but without the active ingredients (caffeine and green tea extract).

Other: Placebo

Interventions

Active (Green tea and caffeine) DIETARY_SUPPLEMENT

Two 355 mL cans of "XS Energy + BURN" drink containing caffeine and green tea extract.

Also known as: XS Energy + BURN

Active

Placebo OTHER

Two 355 mL cans of placebo drink but without the active ingredients (caffeine and green tea extract).

Placebo

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Passing the Exercise and Sport Science Australia adult pre-exercise screening system (APSS) stage 1 \& 2 (see appendix 4).
• Between the ages of 18 and 45,
• Not sedentary, and not completing more than 150 minutes of low and/or moderate and/or or vigorous intensity endurance exercise a week,
• Ability to commit to in principle fulfilment of all 3 trial visits,
• No history of coagulopathy e.g., DVT, stroke,
• No known heart disease,
• No known pancreatic insufficiency,
• No known inflammatory bowel disease, or prior bowel resection or bypass surgery (excluding gastric banding and sleeve),
• BMI of 22.0 to 34.9 kg/m2,
• No known allergies to caffeine or green tea extract,
• No known type I or II diabetes,
• No uncontrolled concurrent illness,
• No known current pregnancy or breastfeeding women
• No current regular consumption of supplements (\>2 times a week) or foods and drinks containing caffeine and/or green tea extracts (\>2 times per day, weekly).
• Agree not to consume caffeine for 12-hours prior to the clinic visit.

You may not qualify if:

• Under the age of 18 or over the age of 45,
• Sedentary, or completing over 150 minutes of low and/or moderate and/or or vigorous intensity endurance exercise a week,
• Inability to commit to in principle fulfilment of all 3 trial visits,
• History of coagulopathy e.g., DVT, stroke,
• Known heart disease,
• Known pancreatic insufficiency,
• Known inflammatory bowel disease, or prior bowel resection or bypass surgery (excluding gastric banding and sleeve),
• BMI \< 22.0 or \> 34.9 kg/m2,
• Known allergies to caffeine or green tea extract,
• Known type I or II diabetes,
• Uncontrolled concurrent illness,
• Taking GLP-1 agonists, caffeine, or any other medication known to affect metabolism.
• Known current pregnancy or breastfeeding women.
• Currently regularly consuming supplements, foods or drinks containing a caffeine and green tea extract blend, or not willing to abstain for the study

Sponsors & Collaborators

• RDC Clinical Pty Ltd: lead
• Amway Corp: collaborator

Study Sites (1)

Griffith University, Gold Coast Campus

Southport, Queensland, 4222, Australia

RECRUITING

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise; Tea; Caffeine

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Plant Preparations; Biological Products; Complex Mixtures; Beverages; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages; Xanthines; Alkaloids; Heterocyclic Compounds; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Central Study Contacts

Llion Roberts, PhD

CONTACT

+61755528451; Llion.Roberts@Griffith.edu.au

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 5, 2026
• First Posted: February 27, 2026
• Study Start: March 26, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: April 16, 2026

Record last verified: 2026-01

Locations

AU (1)