Inflammation Indıces and Mortality in Adult Crush Syndrome

NCT07433127 | Completed

• 1 other identifier: B.30.2.ATA.0.01.00/756
• Study Type: observational
• Target: 325
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective observational cohort study aims to evaluate the prognostic value of inflammatory hematological indices, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and pan-immune-inflammation value (PIV), in predicting 28-day mortality in adult patients with crush syndrome admitted to the intensive care unit (ICU). Patients aged 18 years and older diagnosed with crush syndrome between January 1, 2018, and September 30, 2025, were included. The primary outcome is 28-day mortality. Secondary outcomes include ICU mortality and in-hospital mortality. The predictive performance of inflammatory indices will be compared with established severity scores such as APACHE II and SOFA.

Conditions

Crush Syndrome; Rhabdomyolysis; Systemic Inflammatory Response; Critical Illness

Keywords

Neutrophil-to-Lymphocyte Ratio; NLR; Platelet-to-Lymphocyte Ratio; PLR; Monocyte-to-Lymphocyte Ratio; MLR; Systemic Immune-Inflammation Index; SII; Systemic Inflammatory Response Index; SIRI; Pan-Immune-Inflammation Value; PIV; APACHE II; SOFA SCORE; 28-day Mortality; Intensive Care Unit

Outcome Measures

Primary Outcomes (1)

• 28-day All-Cause Mortality

  All-cause mortality occurring within 28 days after intensive care unit (ICU) admission in adult patients diagnosed with crush syndrome.

  28 Days

Secondary Outcomes (2)

• ICU Mortality

  During ICU stay (up to 28 days)

• In-Hospital Mortality

  During hospital stay (up to 90 days)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients diagnosed with crush syndrome and admitted to the intensive care unit of Ataturk University Hospital between January 2018 and September 2025.

You may qualify if:

• Age ≥18 years
• Diagnosis of crush syndrome based on clinical and laboratory findings
• Admission to the intensive care unit (ICU) between January 1, 2018 and September 30, 2025
• Availability of complete blood count parameters within the first 24 hours of ICU admission

You may not qualify if:

• Age \<18 years
• Incomplete medical records
• Missing laboratory data required for calculation of inflammatory indices
• Patients discharged or transferred within 24 hours of ICU admission

Sponsors & Collaborators

• Ataturk University: lead

Study Sites (1)

Ataturk University Research Hospital

Erzurum, 20100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Crush Syndrome; Rhabdomyolysis; Critical Illness

Condition Hierarchy (Ancestors)

Crush Injuries; Wounds and Injuries; Shock, Traumatic; Muscular Diseases; Musculoskeletal Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Anesthesiology and Reanimation

Study Record Dates

• First Submitted: February 19, 2026
• First Posted: February 25, 2026
• Study Start: January 1, 2018
• Primary Completion: October 28, 2025
• Study Completion: October 28, 2025
• Last Updated: February 25, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)