Inflammation Indıces and Mortality in Adult Crush Syndrome

NCT07433127 | Completed

• 1 other identifier: B.30.2.ATA.0.01.00/756
• Study Type: observational
• Target: 325
• Locations: 1 country
• Sites: 1

Brief Summary

This single-center, retrospective observational cohort study evaluated the prognostic value of complete blood count-derived inflammatory indices - the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and pan-immune-inflammation value (PIV) - for the prediction of 28-day mortality in adult patients with crush syndrome admitted to the intensive care unit (ICU). Consecutive patients aged 18 years and older who were diagnosed with crush syndrome and admitted to the ICU between January 1, 2018, and September 30, 2025, were included. All indices were calculated from the complete blood count obtained within the first 24 hours of ICU admission. The primary and only outcome was 28-day mortality. The discrimination and independent prognostic value of the inflammatory indices were compared with the APACHE II and SOFA scores, and their incremental value beyond these established severity scores was assessed.

Conditions

Crush Syndrome; Rhabdomyolysis; Systemic Inflammatory Response; Critical Illness

Keywords

Neutrophil-to-Lymphocyte Ratio; NLR; Platelet-to-Lymphocyte Ratio; PLR; Monocyte-to-Lymphocyte Ratio; MLR; Systemic Immune-Inflammation Index; SII; Systemic Inflammatory Response Index; SIRI; Pan-Immune-Inflammation Value; PIV; APACHE II; SOFA SCORE; 28-day Mortality; Intensive Care Unit

Outcome Measures

Primary Outcomes (1)

• 28-day All-Cause Mortality

  All-cause mortality within 28 days of intensive care unit (ICU) admission in adult patients with crush syndrome.

  28 days from ICU admission

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients diagnosed with crush syndrome and admitted to the intensive care unit of Ataturk University Hospital between January 2018 and September 2025.

You may qualify if:

• Age ≥18 years
• Diagnosis of crush syndrome based on clinical and laboratory findings
• Admission to the intensive care unit (ICU) between January 1, 2018 and September 30, 2025
• Availability of complete blood count parameters within the first 24 hours of ICU admission

You may not qualify if:

• Age \<18 years
• Incomplete medical records
• Missing laboratory data required for calculation of inflammatory indices
• Patients discharged or transferred within 24 hours of ICU admission

Sponsors & Collaborators

• Ataturk University: lead

Study Sites (1)

Ataturk University Research Hospital

Erzurum, 20100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Crush Syndrome; Rhabdomyolysis; Critical Illness

Condition Hierarchy (Ancestors)

Crush Injuries; Wounds and Injuries; Shock, Traumatic; Muscular Diseases; Musculoskeletal Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Anesthesiology and Reanimation

Study Record Dates

• First Submitted: February 19, 2026
• First Posted: February 25, 2026
• Study Start: January 1, 2018
• Primary Completion: October 28, 2025
• Study Completion: October 28, 2025
• Last Updated: August 18, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)