ICU Admission Diagnoses and ICU Mortality

NCT07369206 | Completed

• 2 other identifiers: ICU-RETRO-20252026/1
• Study Type: observational
• Target: 1,248
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective cohort study will evaluate whether syndromic clinical diagnoses present at ICU admission are associated with ICU mortality, independent of physiologic severity scores. Adult patients admitted to a tertiary mixed ICU during 2025 will be assessed.

Conditions

Critical Illness; Sepsis; Septic Shock; Acute Respiratory Failure; Multiple Organ Dysfunction Syndrome; Acute Respiratory Distress Syndrome (ARDS)

Keywords

Intensive Care Unit; ICU Mortality; Admission Diagnosis; Retrospective Cohort; Severity Score; APACHE II; SAPS; SOFA; Length of Stay

Outcome Measures

Primary Outcomes (1)

• ICU mortality

  Death occurring during the index ICU stay (ICU mortality), abstracted from electronic medical records.

  From ICU admission until ICU discharge (end of index ICU stay), assessed up to 90 days

Secondary Outcomes (2)

• ICU length of stay (LOS)

  From ICU admission to ICU discharge (index ICU stay), assessed at ICU discharge (up to 90 days)

• ICU discharge disposition

  At ICU discharge (index ICU stay; assessed at the time of ICU discharge in the medical record, up to 90 days)

Study Arms (1)

Adult ICU admissions (2025)

Adult patients (≥18 years) admitted to a tertiary mixed intensive care unit between January 1, 2025 and December 31, 2025. For patients with multiple ICU admissions, only the first ICU admission will be included. Data will be abstracted retrospectively from electronic medical records and ICU charts; variables will be recorded based on the first 24 hours after ICU admission.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients admitted to the tertiary mixed ICU of Atatürk University Faculty of Medicine (Department of Anesthesiology and Reanimation) between January 1 2024 and December 31 2025. Data will be collected retrospectively from hospital information systems and ICU records, based on the first 24 hours after ICU admission.

You may qualify if:

• Adult patients (≥18 years) admitted to the ICU between January 1, 2025 and December 31, 2025.
• If a patient has more than one ICU admission during the study period, only the first ICU admission will be included.

You may not qualify if:

• ICU stay \<24 hours.
• Missing essential data preventing assessment of the primary outcome (ICU mortality) and/or calculation of severity scores (APACHE II, SAPS, SOFA).

Sponsors & Collaborators

• Ataturk University: lead

Study Sites (1)

Ataturk University

Erzurum, 25240, Turkey (Türkiye)

Location

Related Publications (4)

• Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA. 1993 Dec 22-29;270(24):2957-63. doi: 10.1001/jama.270.24.2957. Erratum in: JAMA 1994 May 4;271(17):1321. PMID: 8254858.

  BACKGROUND

• Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985 Oct;13(10):818-29. PMID: 3928249.

  BACKGROUND

• Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013 Nov 21;369(21):2063. doi: 10.1056/NEJMc1312359. PMID: 24256390

  BACKGROUND

• Vincent JL, Marshall JC, Namendys-Silva SA, François B, Martin-Loeches I, Lipman J, Reinhart K, Antonelli M, Pickkers P, Njimi H, Jimenez E, Sakr Y; ICON investigators. Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit. Lancet Respir Med. 2014 May;2(5):380-6. doi: 10.1016/S2213-2600(14)70061-X. Epub 2014 Apr 14. PMID: 24740011

  BACKGROUND

MeSH Terms

Conditions

Critical Illness; Sepsis; Shock, Septic; Respiratory Distress Syndrome; Multiple Organ Failure

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Shock; Lung Diseases; Respiratory Tract Diseases; Respiration Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 8, 2026
• First Posted: January 27, 2026
• Study Start: January 30, 2026
• Primary Completion: February 2, 2026
• Study Completion: February 2, 2026
• Last Updated: February 4, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)