Diagnostic and Prognostic Value of D-Lactate and Scube-1 Levels in Critically Ill Patients

NCT06704438 | Completed

• 1 other identifier: 2019/17348
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators aimed to investigate the diagnostic and prognostic levels of D-Lactate and SCUBE-1 in critically ill patients being admitted to the emergency department.

Conditions

Critical Illness; D-Lactate; SCUBE-1

Keywords

D-Lactate; SCUBE-1; Critical Illness

Outcome Measures

Primary Outcomes (1)

• Comparison of D-Lactate and SCUBE-1 levels in patients who were diagnosed according to the criteria as being critically ill by the ED responsible physician and a control group

  The investigators compared the plasma blood levels of biomarkers in both groups

  The study was conducted with blood samples taken at the time of admission. The outcome measure will be assessed up to 24 weeks.

Study Arms (2)

Control Group

The control group consisted of healthy individuals without any disease who voluntarily participated in the study.

Diagnostic Test: D-Lactate

Patients Group

Patients over the age of 18 who were diagnosed as critically ill by the emergency department physician and who gave informed consent were included in the study.

Diagnostic Test: D-Lactate

Interventions

D-Lactate DIAGNOSTIC_TEST

D-Lactate and SCUBE-1 can be used as early diagnosis and mortality indicators in critically ill patients.

Control Group; Patients Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who were diagnosed according to the criteria as being critically ill by the ED responsible physician (patients whose basic vital functions are unstable, who receive supportive treatment or whose general condition is expected to deteriorate) were included. Patients over 18 years of age who agreed to participate in the study were included after consent was obtained from the patient or their relatives. Patients who did not meet the definition of critical patients, whose follow-up was incomplete, who did not want to participate in the study, pregnant women, and patients under 18 years of age were all excluded. A healthy control group was formed from the relatives of the patients who came to the ED outpatient clinics, as well as hospital staff who wanted to participate in the study. Critical patients were divided into the following seven groups according to their emergency department diagnosis: central nervous system, cardiovascular system, respiratory system, gastrointestinal syst

You may qualify if:

• Age 18 years or older Evaluated as critically ill by emergency department physician

You may not qualify if:

• Patients not meeting critical illness criteria Patients with incomplete follow-up records Patients who declined to participate in the study Pregnant women Individuals under 18 years of age

Sponsors & Collaborators

• Kanuni Sultan Suleyman Training and Research Hospital: lead

Study Sites (1)

Kanuni SUltan Suleyman Training and Research Hospital

Istanbul, 34303, Turkey (Türkiye)

Location

Related Publications (3)

• Mitarai T, Gordon AJ, Nudelman MJR, Urdaneta AE, Nesbitt JL, Niknam K, Graber-Naidich A, Wilson JG, Kohn MA. Association of an Emergency Critical Care Program With Survival and Early Downgrade Among Critically Ill Medical Patients in the Emergency Department. Crit Care Med. 2023 Jun 1;51(6):731-741. doi: 10.1097/CCM.0000000000005835. Epub 2023 Apr 3.

  PMID: 37010317 BACKGROUND

• Tahirli T, Altuncı YA, Yalçınlı S. The Evaluation of In-Hospital Transportation of Emergency Room Critically Ill Patients. Genel Tıp Derg

  BACKGROUND

• Robertson LC, Al-Haddad M. Recognizing the critically ill patient. Anaesthesia & Intensive Care Medicine

  BACKGROUND

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ASISTANT PROFESSOR

Study Record Dates

• First Submitted: November 21, 2024
• First Posted: November 26, 2024
• Study Start: July 25, 2019
• Primary Completion: January 1, 2020
• Study Completion: January 15, 2020
• Last Updated: November 26, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)