NCT07432243

Brief Summary

This study is a sub-study of Mapping Antenatal Maternal Stress (MAMS). Women previously enrolled in MAMS, their children and their partners/spouses were recruited for a set of more comprehensive assessments to characterise early neurodevelopmental outcomes in children, their associations with antenatal and postnatal maternal emotional health, and how paternal genetics, mental health and parenting styles and perceptions may influence this relationship.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
587

participants targeted

Target at P75+ for all trials

Timeline
60mo left

Started Sep 2021

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress49%
Sep 2021Jun 2031

Study Start

First participant enrolled

September 22, 2021

Completed
4.4 years until next milestone

First Submitted

Initial submission to the registry

February 12, 2026

Completed
13 days until next milestone

First Posted

Study publicly available on registry

February 25, 2026

Completed
5.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2031

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2031

Last Updated

February 25, 2026

Status Verified

January 1, 2026

Enrollment Period

9.7 years

First QC Date

February 12, 2026

Last Update Submit

February 18, 2026

Conditions

Neurological and Mental Health ConditionsGenetic SusceptibilitySocioeconomic FactorsPsychology, Social

Keywords

NeurodevelopmentGeneticsMental Health

Outcome Measures

Primary Outcomes (4)

  • Determine specific contribution of maternal prenatal mood factor components to specific child developmental outcomes

    Analyses of maternal prenatal mood factors (e.g: maternal positive health, anxiety, depressive symptoms etc) to determine which components contribute to specific neurocognitive, socio-emotional and developmental outcomes in children

    From pregnancy to postnatal 6 years

  • Functional and structural neuroimaging during infancy and early childhood

    To examine functional dynamics and structural patterns of the brain anatomy and connectivity and its relation to child neurocognitive outcomes

    From birth to postnatal 6 years

  • Contextual variables that moderate association between parental mental health and child outcomes

    To assess perinatal parental mental health in relation to child developmental outcomes using standardized clinical measures that have predictive validity for cognitive, emotional and social outcomes in young children, including SES, family cohesion, parental attitudes and genetics

    From pregnancy to postnatal 6 years

  • Influence of paternal factors on relationship between maternal mental mood and child outcomes

    To examine examine paternal factors such as genetics, emotional health and parenting perceptions as modulators and mediators of maternal mental mood on child's socio-emotional, cognitive and developmental outcomes

    From pregnancy to postnatal 6 years

Eligibility Criteria

Age21 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Singapore residents

You may qualify if:

  • Mother:
  • Enrolled in MAMS study
  • Intends for herself and her child to stay in Singapore for the next 5 years
  • Access to a smartphone or standard laptop/ desktop
  • Willing to take part in this study and able to provide written consent
  • Aged 21-42 years
  • Father:
  • Partner is already enrolled in MAMS study
  • Aged 21-75 years

You may not qualify if:

  • Mother:
  • Women with pre-existing or a history of psychotic depression, schizophrenia and bipolar disorders
  • Women currently on oral/IV steroids and/or thyroids medication
  • Women with a history of thyroid disease
  • Women currently involved in on-going interventional randomized controlled trials

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Institute for Human Development and Potential

Singapore, 117609, Singapore

Location

Biospecimen

Retention: SAMPLES WITH DNA

Collection of human biological materials, such as buccal and saliva

MeSH Terms

Conditions

Neurologic ManifestationsGenetic Predisposition to DiseasePsychological Well-Being

Condition Hierarchy (Ancestors)

Nervous System DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsDisease SusceptibilityDisease AttributesPathologic ProcessesPersonal SatisfactionBehavior

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 12, 2026

First Posted

February 25, 2026

Study Start

September 22, 2021

Primary Completion (Estimated)

June 1, 2031

Study Completion (Estimated)

June 1, 2031

Last Updated

February 25, 2026

Record last verified: 2026-01

Locations

SG(1)