Mapping Antenatal Maternal Stress

NCT07432217 | Active Not Recruiting DMC

• 1 other identifier: 2018/00967
• Study Type: observational
• Target: 1,419
• Locations: 1 country
• Sites: 1

Brief Summary

This study recruits women from early-mid pregnancy and later follows their children after birth, tracking both the mother and child until the child reaches at least 4 years of age. The study aims to examine the determinants of maternal mental health during pregnancy and how genetic factors could influence maternal mental health and child outcomes.

Conditions

Neurological and Mental Health Conditions; Genetic Susceptibility; Socioeconomic Factors; Psychology, Social

Keywords

Neurodevelopment; Genetics; Mental Health

Outcome Measures

Primary Outcomes (3)

• Cumulative psychosocial risk index of maternal depression and anxiety

  To create a cumulative risk index by collecting data using existing validated measures on known risk factors for maternal depression and anxiety, including 1) low socio-economic status, 2) poor marital relations, 3) low social support, 4) high levels of perceived stress, 5) high levels of neuroticism, 6) low self-esteem, 7) poor family function, and 8) childhood adversity in the form of maltreatment and/or poor parental relations.

  From pregnancy up to 2 years postnatal

• Polygenic risk score for differential susceptibility to environmental susceptibility

  To identify genotypic variation associated with perinatal maternal mental health

  From pregnancy up to 2 years postnatal

• Determinants of maternal symptoms of depression and anxiety with those that predict positive maternal mental health

  To compare the determinants of maternal symptoms of depression and anxiety with those that predict the level of positive mental health

  From pregnancy up to 2 years postnatal

Secondary Outcomes (3)

• Influence of perinatal maternal mental health in relation to child development outcomes

  From pregnancy to postnatal 6 years

• Determine specific contribution of maternal prenatal mood factor components to specific developmental outcomes in children

  From pregnancy to postnatal 6 years

• Influence of genetic susceptibility on maternal mental health and child outcomes

  From pregnancy to postnatal 6 years

Study Arms (1)

Pregnant mothers, infants and children

Mothers who are aged 21 - 40 years, below 24 weeks of pregnancy by ultrasonography, are willing to respond to questionnaires in English, and intend to stay in Singapore with her child for the next 5 years are eligible for the study. Babies born from these mothers will be followed up until the child is at least 4 years old.

Eligibility Criteria

• Age: 21 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Singapore

You may qualify if:

• Mothers aged 21 - 40 years
• Below 24 weeks of pregnancy by ultrasonography
• Proficient and able to respond to questionnaires in English
• Intends for herself and her child to stay in Singapore for the next 5 years
• Access to a smartphone or standard laptop/desktop
• All participants whose data on pregnancy follow-up and delivery would be available from healthcare professionals
• Willing to take part in this study and able to provide written consent

You may not qualify if:

• Women with pre-existing or a history of psychotic depression, schizophrenia and bipolar disorders
• Women currently on oral/IV steroids and/or thyroids medication
• Women with a history of thyroid disease
• Women who are pregnant via any assisted reproduction
• Women carrying multiples
• Women currently enrolled into any interventional randomized controlled trials

Sponsors & Collaborators

• Institute of Mental Health, Singapore: collaborator
• KK Women's and Children's Hospital: collaborator
• Institute for Human Development and Potential (IHDP), Singapore: lead
• National University Hospital, Singapore: collaborator
• McGill Faculty of Medicine: collaborator

Study Sites (1)

Institute for Human Development and Potential

Singapore, 117609, Singapore

Location

Biospecimen

Retention: SAMPLES WITH DNA

Collection of human biological materials, such as buccal, saliva and blood

MeSH Terms

Conditions

Neurologic Manifestations; Genetic Predisposition to Disease; Psychological Well-Being

Condition Hierarchy (Ancestors)

Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Disease Susceptibility; Disease Attributes; Pathologic Processes; Personal Satisfaction; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 12, 2026
• First Posted: February 25, 2026
• Study Start: September 30, 2019
• Primary Completion (Estimated): June 1, 2029
• Study Completion (Estimated): June 16, 2029
• Last Updated: February 25, 2026

Record last verified: 2026-02

Locations

SG (1)