Chronic Kidney Disease Associated Diet

NCT07427069 | Not Yet Recruiting DMC

• 1 other identifier: KBHDiet09/25
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to investigate the relationship between chronic kidney disease (CKD) and periodontitis, and to evaluate the potential mediating role of dietary inflammatory potential, measured by the Dietary Inflammatory Index (DII), in this association. The main question it aims to answer is: Does a pro-inflammatory diet, as reflected by a higher DII score, exacerbate periodontal inflammation in individuals with chronic kidney disease? Participants will include adults diagnosed with CKD at various stages. Periodontal status will be assessed through clinical parameters such as probing depth, clinical attachment loss, and bleeding on probing. Dietary intake will be evaluated using a validated food frequency questionnaire, and DII scores will be calculated accordingly. The study will aim to observe and analyze whether dietary inflammation contributes to increased periodontal disease severity in CKD patients, potentially offering insight into modifiable risk factors relevant to both systemic and oral health.

Conditions

Chronic Kidney Disease; Periodontitis; Diet, Food and Nutrition

Keywords

Chronic kidney disease; periodontitis; diet; inflammation

Outcome Measures

Primary Outcomes (1)

• Dietary Inflammatory Index

  The Dietary Inflammatory Index (DII) provides a score that measures the potential for a person's diet to cause inflammation in the body. This index is based on the pro- or anti-inflammatory effects of consumed foods and nutrients. Participants' 3-day food intake records will be entered into the system, and average daily energy intake, macronutrients, and micronutrients will be calculated. Based on the food records, average daily intake of 36 nutrients will be determined, and DII scores will be derived from these nutrient parameters. A lower score indicates a more antiinflammatory diet, while a higher score indicates a more proinflammatory diet.

  Day 1

Secondary Outcomes (5)

• Clinical Periodontal Parameters (Plaque Index)

  Day 1

• Clinical Periodontal Parameters (Gingival Index)

  Day 1

• Periodontal Clinical Parametres (Bleeding on Probing Index)

  Day 1

• Periodontal Clinical Parametres (Probing Pocket Depth)

  Day 1

• Periodontal Clinical Parametres (Clinical Attachment Loss)

  Day 1

Other Outcomes (15)

• Creatinine

  Day 1

• Albumin

  Day 1

• Blood urea nitrogen

  Day 1

Study Arms (1)

Patients diagnosed with chronic kidney disease

Chronic kidney disease is diagnosed if the eGFR is below 60 ml/min/1.73 m2 for at least 3 months or if the urine albumin-creatinine ratio is above 30 mg/g (proteinuria).

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients diagnosed with chronic kidney disease who come to the Periodontology Clinic of Recep Tayyip Erdoğan University Faculty of Dentistry for routine periodontal treatment

You may qualify if:

• Being between 18 and 65 years of age
• Being diagnosed with Chronic Kidney Disease (having an eGFR below 60 ml/min/1.73 m² for at least 3 months or a urine albumin-to-creatinine ratio above 30 mg/g (proteinuria))
• Having at least 20 teeth
• Not having received periodontal therapy in the last 6 months
• Not having taken antibiotics, steroids, and/or nonsteroidal anti-inflammatory drugs in the last 3 weeks
• Not having any autoimmune disease, osteoporosis, or cancer
• Not taking immunosuppressive medications, oral contraceptives, Not taking bisphosphonates
• Not being pregnant
• Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)
• Not taking chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)
• Not taking antioxidant supplements in the last 6 months

You may not qualify if:

• Patients with an active infectious disease,
• Those taking medications that could affect periodontal tissues,
• History of endocarditis,
• Recent antibiotic use (within 4 months),
• Alcohol/drug use,
• Psychological disorders,
• Eating disorders,
• Dementia,
• Pregnancy and breastfeeding,
• Patients who did not sign the informed consent form

Sponsors & Collaborators

• Recep Tayyip Erdogan University Training and Research Hospital: lead

Study Sites (1)

Department of Periodontology of the Faculty of Dentistry of Recep Tayyip Erdogan University

Rize, Rize Province, 53200, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum blood samples Routine blood tests will include biomarkers such as creatinine, albumin, blood urea nitrogen, GFR, hsCRP, vitamin D, platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), uric acid, ferritin, iron, phosphorus, calcium, and parathyroid hormone. The spot urine albumin-to-creatinine ratio (ACR) will be recorded.

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Periodontitis; Inflammation

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Central Study Contacts

Oguz KOSE, Professor Dr.

CONTACT

+90 541 348 64 65; oguz.kose@erdogan.edu.tr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof. Dr.

Study Record Dates

• First Submitted: February 15, 2026
• First Posted: February 23, 2026
• Study Start: April 20, 2026
• Primary Completion (Estimated): October 19, 2026
• Study Completion (Estimated): November 16, 2026
• Last Updated: February 24, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)