Feasibility of Modulating Cognitive Control in OCD

NCT07419009 | Not Yet Recruiting FDA Device

• 1 other identifier: STUDY02003117
• Study Type: interventional
• Target: 12
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study tests out procedures to look at whether a type of brain stimulation called transcranial magnetic stimulation impacts flexible shifts in behavior in obsessive-compulsive disorder (OCD). This study examines whether study procedures are feasible and acceptable to people participating in the study, but does not determine whether this type of brain stimulation causes changes.

Conditions

Obsessive-Compulsive Disorder (OCD)

Outcome Measures

Primary Outcomes (1)

• Rate of enrollment

  Percent of screened participants who are determined to be eligible and enrolled.

  At study enrollment

Secondary Outcomes (2)

• Rates of visit completion

  From enrollment to date of post-TMS study visit (approximately 1 week)

• Peak cTBS intensity tolerated

  From enrollment to end of TMS sessions (approximately 1 week)

Study Arms (2)

Obsessive-compulsive disorder (OCD)

OTHER

Device: continuous theta-burst transcranial magnetic stimulation (cTBS)

Healthy Adult Participants

OTHER

Device: continuous theta-burst transcranial magnetic stimulation (cTBS)

Interventions

continuous theta-burst transcranial magnetic stimulation (cTBS) DEVICE

3 consecutive daily sessions of cTBS

Healthy Adult Participants; Obsessive-compulsive disorder (OCD)

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Current primary DSM-5 OCD diagnosis and current Y-BOCS total score of ≥16 (OCD group, only) or no current diagnosis of an emotional disorder, and no known history of OCD, PTSD, anxiety disorder(s), or recurrent major depressive disorder (Healthy participant group, only)
• years of age
• ability to speak, read, write, and understand English sufficiently well to complete study procedures and provide informed consent
• psychotherapy and/or psychiatric medication use remain stable for 6 weeks prior to study entry

You may not qualify if:

• Presence of current psychiatric diagnosis (healthy control group, only)
• active substance use disorder
• history of mania or hypomania, or lifetime presence of significant psychotic symptoms
• active suicidal or homicidal ideation
• use of medications known to reduce seizure threshold (e.g., stimulants)
• organic brain disease or injury representing a contraindication to TMS
• any health problems that would interfere with safe and/or practical study participation, including contraindications to TMS (e.g., seizure disorder, presence of metal hardware that would come in close contact with the discharging coil)
• current pregnancy or planning to become pregnant during the study period

Sponsors & Collaborators

• Dartmouth-Hitchcock Medical Center: lead

MeSH Terms

Conditions

Obsessive-Compulsive Disorder

Condition Hierarchy (Ancestors)

Anxiety Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Psychologist

Study Record Dates

• First Submitted: February 6, 2026
• First Posted: February 18, 2026
• Study Start: February 15, 2026
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: February 18, 2026

Record last verified: 2026-02