Identifying Risk Factors and Predicting Future Health Outcomes for Korean Patients With Heart and Blood Vessel Diseases: A Long-term Follow-up Study

NCT07393412 | Recruiting

• 1 other identifier: SMC IRB 2025-12-061
• Study Type: observational
• Target: 800,000
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to establish a comprehensive, long-term clinical registry infrastructure for heart and brain vascular diseases (cardiovascular diseases and stroke) at Samsung Medical Center. In South Korea, these diseases are a leading cause of death, with a rapidly increasing burden due to an aging population and changing lifestyles. Despite this, there is a lack of large-scale, systematic data specifically focused on the long-term clinical course and unique characteristics of Korean patients. The central hypothesis of this study is that the establishment of a standardized registry infrastructure-integrating both retrospective (historical) and prospective (future) data collection-will provide a more accurate and comprehensive understanding of the natural history and risk factors of heart and brain vascular diseases in the Korean population than currently available fragmented data. By combining existing medical records with ongoing patient follow-up, this infrastructure will serve as a critical scientific platform for developing personalized prevention and precision medicine strategies. By building this organized data collection system, the study will: Construct a robust infrastructure to collect uniform, high-quality clinical data, encompassing both past medical history (retrospective) and future clinical progress (prospective) from a large population of Korean patients. Monitor long-term health outcomes and the progression of diseases by tracking patients over many years. Analyze the interaction between various risk factors and patient outcomes to identify population-specific patterns. Create a scalable platform that can integrate advanced technologies, such as multi-omics and digital health tools, for future research. Ultimately, this integrated registry infrastructure is expected to provide the essential scientific evidence needed to optimize clinical guidelines and improve the long-term quality of life for patients with heart and brain vascular diseases in Korea.

Conditions

Cerebro Vascular Disease; Cardiovascular Diseases (CVD)

Outcome Measures

Primary Outcomes (1)

• Incidence of Major Adverse Cardio-Cerebrovascular Events (MACCE)

  Up to 20 years (from the date of enrollment until the end of the follow-up period)

Interventions

Revascularization Procedures PROCEDURE

Surgical or interventional procedures such as PCI (Percutaneous Coronary Intervention) or stent thrombectomy for stroke.

Standard Medical Therapy DRUG

Routine pharmacological treatments including antiplatelets, antihypertensives

Lifestyle Modification BEHAVIORAL

Habitual factors including smoking cessation, physical activity, and dietary habits monitored during the follow-up.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study population consists of patients diagnosed with or treated for heart and brain vascular diseases (cardiovascular diseases and stroke) at Samsung Medical Center, a tertiary academic hospital in Seoul, Korea. This cohort includes: Retrospective Group: Patients with clinical records within the hospital's historical database to analyze past clinical courses and long-term outcomes. Prospective Group: Patients newly visiting or currently under follow-up care at the heart, stroke, and vascular centers who consent to long-term monitoring. The population covers a wide clinical spectrum, from acute emergency cases (e.g., myocardial infarction, ischemic stroke) to chronic management.

You may qualify if:

• A patient who visited Samsung Medical Center due to cardiovascular and cerebrovascular disease.

You may not qualify if:

• A patient deemed unable to participate in the study based on the judgment of the medical staff.

Sponsors & Collaborators

• Samsung Medical Center: lead

Study Sites (1)

Samsung Medical Center

Seoul, South Korea

RECRUITING

MeSH Terms

Conditions

Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 20 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 30, 2026
• First Posted: February 6, 2026
• Study Start: February 2, 2026
• Primary Completion (Estimated): November 27, 2026
• Study Completion (Estimated): December 31, 2040
• Last Updated: April 28, 2026

Record last verified: 2026-04

Locations

KR (1)