Clinico-radiological Correlations in Cerebro-VASCULAR Disease

NCT07493694 | Not Yet Recruiting

• 1 other identifier: VASCULAR-BRAIN
• Study Type: observational
• Target: 1,143
• Locations: 0 countries
• Sites: N/A

Brief Summary

This observational retrospective and prospective registry aims to explore the relationships between clinical manifestations and radiological findings in cerebrovascular diseases. These conditions are characterized by heterogeneous radiological presentations and different etiologies, posing challenges for accurate diagnosis and effective treatment. Understanding these correlations is essential for advancing diagnostic accuracy and therapeutic strategies.

Conditions

Cerebro Vascular Disease

Outcome Measures

Primary Outcomes (1)

• Proportion of patients with each key MRI/CT finding in cerebrovascular disease (lesion location, vessel involvement, hemorrhagic transformation)

  Primary Outcome Measure: Diagnostic imaging trends in cerebrovascular disease Description: Key imaging findings from first MRI/CT (e.g., lesion location, vessel involvement; %).

  Baseline (at diagnosis), up to 20 years

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The registry will focus on adults aged 18 to 100 of both genders diagnosed with various cerebrovascular diseases based on clinical and imaging evaluations. Participants will be selected from a retrospective registry of patients who have undergone MRI or CT scans for clinical indications. In addition to the retrospective cohort, the registry will also include a prospective component, enrolling newly diagnosed patients who meet the same eligibility criteria.

You may qualify if:

• Age Range: 18-100 years old.
• Must have undergone a CT or MRI scan of the central nervous system (CNS) (for clinical reasons).

You may not qualify if:

• Alternative diagnosis to vascular pathology that explains clinical symptoms.
• MRI or CT non-diagnostic or non-evaluable MRI due to motion artifacts.

Sponsors & Collaborators

• IRCCS San Raffaele: lead

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Target Duration: 20 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: March 5, 2026
• First Posted: March 25, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): April 1, 2046
• Study Completion (Estimated): April 1, 2046
• Last Updated: March 30, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share