Study Protocol: 10-Year Follow-Up of Patients Screened for Cardiovascular Risk by the "All With Heart" Association - Development of a Morocco-Specific Risk Score

NCT07294937 | Recruiting

• 1 other identifier: 126/24
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 2

Brief Summary

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and their prevalence is steadily increasing in Morocco. Between 2010 and 2012, the "All with heart" Association conducted a large-scale cardiovascular screening campaign in the Greater Casablanca region, involving more than 10,000 adults aged over 40 years. This 10-year follow-up study aims to evaluate long-term cardiovascular outcomes and to develop a Morocco-specific cardiovascular risk score. Follow-up data will be collected through phone calls, WhatsApp, or SMS with participants or their families to document cardiovascular deaths, myocardial infarctions, and strokes. Statistical analyses, including survival analysis and multivariate logistic regression, will be used to identify significant risk factors and to construct a predictive risk model tailored to the Moroccan population. The study received a favorable opinion from the Rabat Ethics Committee. Written informed consent will be obtained from all participants or their families prior to data collection. The findings are expected to enhance understanding of cardiovascular risk evolution in Morocco and to provide a validated, population-specific risk score to support prevention and patient management strategies.

Conditions

Cardiovascular Diseases (CVD)

Outcome Measures

Primary Outcomes (2)

• Incidence of Major Cardiovascular Events (MACE)

  Occurrence of major cardiovascular events (myocardial infarction, stroke, or cardiovascular death) among participants screened for cardiovascular risk between 2010 and 2012 by the "All with heart" Association. Events will be identified during the 10-year follow-up period through participant or family contact (phone, WhatsApp, or SMS) and verified through available medical records when possible.

  10 years after initial screening (2010-2012)

• Development and Validation of a Morocco-Specific Cardiovascular Risk Score

  Development and internal validation of the Morocco-Specific Cardiovascular Risk Score, a composite risk prediction score estimating the 10-year probability of major cardiovascular events including myocardial infarction, stroke, or cardiovascular death. The score will be derived from baseline cardiovascular risk factors collected during the initial screening and weighted using multivariable regression models based on outcomes observed during the 10-year follow-up. The score will be expressed on a scale ranging from 0 to 100, where higher scores indicate a higher cardiovascular risk and therefore a worse outcome. Model performance will be assessed using discrimination and calibration measures, including the area under the receiver operating characteristic curve and calibration analyses.

  Baseline (2010-2012) and 10-year follow-up (2022)

Secondary Outcomes (1)

• Incidence of Minor Cardiovascular Events

  10 years after initial screening (2010-2012)

Other Outcomes (3)

• Number of Hospitalizations Related to Cardiovascular Diseases

  10 years after initial screening (2010-2012)

• Change in Cardiovascular Risk Factors Over Time

  10 years after initial screening (2010-2012)

• Quality of Life Assessment

  10 years after initial screening (2010-2012)

Study Arms (1)

Participants screened for cardiovascular risk (TAC cohort)

Participants aged 40 years and older who were screened for cardiovascular risk between 2010 and 2012 by the "All with heart" Association in the Greater Casablanca region. This cohort is being followed 10 years after the initial screening to assess cardiovascular outcomes (death, myocardial infarction, stroke) and to develop a Morocco-specific cardiovascular risk score. No intervention is applied; the study is purely observational.

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population includes adults aged 40 years and older who were screened for cardiovascular risk between 2010 and 2012 by the "All with heart" Association in the Greater Casablanca region, Morocco. Approximately 10,000 individuals participated in the original screening campaign, which collected data on anthropometric, biological, and lifestyle risk factors. For the 10-year follow-up, all eligible Moroccan participants from the initial screening will be contacted by phone, WhatsApp, or SMS to collect updated information on cardiovascular events, hospitalizations, and mortality. This population represents a community-based cohort reflecting the general adult population at risk of cardiovascular disease in Morocco.

You may qualify if:

• Adults aged 40 years or older at the time of the initial screening (2010-2012).
• Individuals who participated in the cardiovascular risk screening campaign conducted by the "All with heart" Association between 2010 and 2012 in the Greater Casablanca region.
• Moroccan nationality.
• Participants or family members who provide written informed consent for participation in the 10-year follow-up study.

You may not qualify if:

• Individuals who refuse to participate in the follow-up study.
• Participants who have moved and cannot be reached by phone, WhatsApp, or SMS.
• Participants who died from non-cardiovascular causes.
• Non-Moroccan participants.

Sponsors & Collaborators

• Moroccan Society of Cardiology: lead
• F&C Clinical Trials: collaborator

Study Sites (2)

Moroccan Society of Cardiology

Casablanca, 20200, Morocco

RECRUITING

Cardiology Centre, Mohammed V Military Hospital, Rabat, Morocco

Rabat, Morocco

RECRUITING

MeSH Terms

Conditions

Cardiovascular Diseases

Central Study Contacts

Najat MOUINE, Professor of Cardiology

CONTACT

+212661202733; mouine2@yahoo.fr

Mohamed ALAMI

CONTACT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 2, 2025
• First Posted: December 19, 2025
• Study Start: October 1, 2025
• Primary Completion: March 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: December 19, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

MO (2)