NCT07385976

Brief Summary

This study will elucidate the role of 3D transvaginal ultrasound in assessing (1) cervical vascularity and blood flow in patients with cervical cancer and cervical intraepithelial neoplasm, and (2) tumor vascularity and blood flow in patients with ovarian cancer.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
56mo left

Started Jan 2026

Longer than P75 for all trials

Geographic Reach
1 country

2 active sites

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress6%
Jan 2026Dec 2030

First Submitted

Initial submission to the registry

January 13, 2026

Completed
6 days until next milestone

Study Start

First participant enrolled

January 19, 2026

Completed
16 days until next milestone

First Posted

Study publicly available on registry

February 4, 2026

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2030

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2030

Last Updated

February 4, 2026

Status Verified

January 1, 2026

Enrollment Period

5 years

First QC Date

January 13, 2026

Last Update Submit

January 27, 2026

Conditions

Cervical CancerCervical Intraepithelial NeoplasmOvarian Cancer

Keywords

3D power Doppler sonographycervical vascularization and blood flow

Outcome Measures

Primary Outcomes (1)

  • Vascularization-flow index

    1. Compare the vascularization-flow index values between cervical cancer, cervical intraepithelial neoplasia and the control group. 2. To assess whether vascularization-flow index is a predictor of progression-free survival in women with ovarian cancer

    3 years

Secondary Outcomes (2)

  • Vascularization index

    3 years

  • Flow index

    3 years

Study Arms (4)

cervical cancer

cervical cancer patients

Diagnostic Test: Doppler ultrasound

cervical intraepithelial neoplasm

cervical intraepithelial neoplasm patients

Diagnostic Test: Doppler ultrasound

control

Gynecological patients without cervical disease

Diagnostic Test: Doppler ultrasound

ovarian cancer

ovarian cancer patients

Diagnostic Test: Doppler ultrasound

Interventions

Doppler ultrasoundDIAGNOSTIC_TEST

3D doppler ultrasound to measure VI, FI, VFI.

cervical cancercervical intraepithelial neoplasmcontrolovarian cancer

Eligibility Criteria

Sexfemale(Gender-based eligibility)
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Women with cervical cancer, cervical intraepithelial neoplasm, ovarian cancer, and the disease-free control

You may qualify if:

  • Regarding the topic "Hemoperfusion characteristics of cervical cancer and precancerous lesions, and the correlation between hemoperfusion and prognosis":
  • Adult women who have had a normal cervical smear within the past three years and have no other gynecological cancers (control group).
  • Adult women with cervical cancer or precancerous lesions.
  • Regarding the topic "Correlation between hemoperfusion and prognosis of ovarian cancer":
  • Adult women suspected of having ovarian cancer, fallopian tube cancer, or peritoneal cancer before surgery.

You may not qualify if:

  • Regarding the topic "Hemoperfusion characteristics of cervical cancer and precancerous lesions of the cervix, and the correlation between hemoperfusion and prognosis":
  • \. Patients who cannot cooperate with vaginal 3D ultrasound scans.
  • Regarding the topic "Correlation between hemoperfusion and prognosis of ovarian cancer":
  • Patients who cannot cooperate with vaginal or abdominal 3D ultrasound scans.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital,

New Taipei City, Banqiao, 22050, Taiwan

Location

Far Eastern Memorial Hospital

New Taipei City, 220, Taiwan

Location

MeSH Terms

Conditions

Uterine Cervical NeoplasmsUterine Cervical DysplasiaOvarian Neoplasms

Interventions

Ultrasonography, Doppler

Condition Hierarchy (Ancestors)

Uterine NeoplasmsGenital Neoplasms, FemaleUrogenital NeoplasmsNeoplasms by SiteNeoplasmsUterine Cervical DiseasesUterine DiseasesGenital Diseases, FemaleFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesGenital DiseasesPrecancerous ConditionsEndocrine Gland NeoplasmsOvarian DiseasesAdnexal DiseasesEndocrine System DiseasesGonadal Disorders

Intervention Hierarchy (Ancestors)

UltrasonographyDiagnostic ImagingDiagnostic Techniques and ProceduresDiagnosis

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Target Duration
3 Months
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Chief, Department of Obstetrics & Gynecology

Study Record Dates

First Submitted

January 13, 2026

First Posted

February 4, 2026

Study Start

January 19, 2026

Primary Completion (Estimated)

December 31, 2030

Study Completion (Estimated)

December 31, 2030

Last Updated

February 4, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

Locations

TW(2)