av Fistula Patency Loss as a Cause of Fistula Failure and Hyperphosphatemia

NCT05569109 | Unknown

• 1 other identifier: av fistula and phosphate
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Assessment of arteriovenous fistula patency loss which leads to av fistula failure and its relation to high serum phosphate level in chronic hemodialysis patients.

Conditions

AV Fistula

Keywords

hyperphosphatemia

Outcome Measures

Primary Outcomes (1)

• measurement of early av fistula patency loss

  early measurement of av fistula patency loss using doppler ultrasound to decrease the fistula failure rate

  baseline

Secondary Outcomes (1)

• measurement if there is a relation between fistula patency loss and hyperphosphatemia

  baseline

Study Arms (2)

av fistula patency loss with hperphosphatemia

hemodialysis patients with av fistula patency loss by doppler ultrasound and hyperphosphatemia

Device: doppler ultrasound

av fistula patency loss with normal phosphate level

hemodialysis patients with av fistula patency loss by doppler ultrasound and normal phosphate level

Device: doppler ultrasound

Interventions

doppler ultrasound DEVICE

doppler ultrasound on arteriovenous fistula in hemodialysis patients

av fistula patency loss with hperphosphatemia; av fistula patency loss with normal phosphate level

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

\- adult patients more than 18 years old with end stage renal disease on regular hemodialysis using arteriovenous fistula

You may qualify if:

• adult patients more than 18 years old with end stage renal disease on regular hemodialysis using arteriovenous fistula

You may not qualify if:

• : patients less than 18 years, patients with peripheral artery diseases, access failure occurred within the first 2 months after fistula surgery, AVF failure was related to an infectious complication and patients with arteriovenous grafts.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Faculty of Medicine Assiut U

Asyut, Egypt

Location

Related Publications (6)

• Tuysuz ME, Dedemoglu M. Calcium phosphate product level as a predictor for arteriovenous fistula re-operations in patients with chronic renal failure. Vascular. 2019 Jun;27(3):284-290. doi: 10.1177/1708538118814611. Epub 2018 Nov 21.

  PMID: 30463499 BACKGROUND

• Cozzolino M, Gallieni M, Brancaccio D. The mechanisms of hyperphosphatemia-induced vascular calcification. Int J Artif Organs. 2008 Dec;31(12):1002-3. doi: 10.1177/039139880803101203.

  PMID: 19115191 BACKGROUND

• Manne V, Vaddi SP, Reddy VB, Dayapule S. Factors influencing patency of Brescia-Cimino arteriovenous fistulas in hemodialysis patients. Saudi J Kidney Dis Transpl. 2017 Mar-Apr;28(2):313-317. doi: 10.4103/1319-2442.202759.

  PMID: 28352013 BACKGROUND

• MacRae JM, Dipchand C, Oliver M, Moist L, Lok C, Clark E, Hiremath S, Kappel J, Kiaii M, Luscombe R, Miller LM; Canadian Society of Nephrology Vascular Access Work Group. Arteriovenous Access Failure, Stenosis, and Thrombosis. Can J Kidney Health Dis. 2016 Sep 27;3:2054358116669126. doi: 10.1177/2054358116669126. eCollection 2016.

  PMID: 28270918 BACKGROUND

• Moghazy KM. Value of color Doppler sonography in the assessment of hemodialysis access dysfunction. Saudi J Kidney Dis Transpl. 2009 Jan;20(1):35-43.

  PMID: 19112217 BACKGROUND

• Huijbregts HJ, Bots ML, Wittens CH, Schrama YC, Moll FL, Blankestijn PJ; CIMINO study group. Hemodialysis arteriovenous fistula patency revisited: results of a prospective, multicenter initiative. Clin J Am Soc Nephrol. 2008 May;3(3):714-9. doi: 10.2215/CJN.02950707. Epub 2008 Feb 6.

  PMID: 18256379 BACKGROUND

MeSH Terms

Conditions

Arteriovenous Fistula; Hyperphosphatemia

Interventions

Ultrasonography, Doppler

Condition Hierarchy (Ancestors)

Arteriovenous Malformations; Vascular Malformations; Cardiovascular Abnormalities; Cardiovascular Diseases; Vascular Fistula; Vascular Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Fistula; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Phosphorus Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Ultrasonography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Central Study Contacts

kerollos labeeb

CONTACT

+0201228182636; kerels011315@med.aun.edu.eg

mohamed hafez

CONTACT

+0201061685353; M.zain2014@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.B.B.CH , M.Sc

Study Record Dates

• First Submitted: September 27, 2022
• First Posted: October 6, 2022
• Study Start: December 1, 2022
• Primary Completion: December 1, 2023
• Study Completion: January 1, 2024
• Last Updated: October 6, 2022

Record last verified: 2022-10

Locations

EG (1)