Ultrasound Evaluation in Carpal Tunnel Syndrome

NCT07433166 | Not Yet Recruiting

• 1 other identifier: CTS-PD-DM-2026
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective cohort study aims to evaluate median nerve cross-sectional area and intraneural vascularity using power Doppler ultrasonography in patients with carpal tunnel syndrome. Ultrasonographic findings will be compared between diabetic and non-diabetic patients. Clinical severity and electrophysiological findings will be correlated with ultrasonographic parameters.

Conditions

Carpal Tunnel Syndrome (CTS)

Keywords

carpal tunnel; ultrasound; power doppler

Outcome Measures

Primary Outcomes (2)

• Intraneural Vascularity

  Intraneural blood flow will be evaluated using power Doppler ultrasonography at the level of the carpal tunnel inlet. The presence and degree of intraneural vascularity will be graded using a semi-quantitative scoring system: 0 = No detectable intraneural flow 1. = Single vessel signal 2. = Multiple vessel signals 3. = Marked hypervascularity The total score ranges from 0 to 3. Higher scores indicate increased intraneural vascularity.

  Baseline

• Cross sectional Area

  The cross-sectional area of the median nerve will be measured using ultrasonography at the level of the pisiform bone (carpal tunnel inlet) and proximal to transvers carpal ligament. Measurements will be obtained by tracing the inner border of the hyperechoic epineurium. Values will be recorded in square millimeters (mm²). Higher values indicate greater nerve swelling.

  baseline

Secondary Outcomes (1)

• Boston Carpal Tunnel Questionnaire

  Baseline, 3th and 6th months

Interventions

Doppler ultrasound DIAGNOSTIC_TEST

The predictive power of cross-sectional area and intraneural blood flow measured by ultrasound on surgical outcomes will be tested.

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Carpal Tunnel Syndrome Patients

You may qualify if:

• clinically and electrophysiologically confirmed carpal tunnel syndrome
• symptom duration \> 3 months
• written informed consent

You may not qualify if:

• previous wrist surgery
• cervical radiculopathy
• inflammatory arthritis
• pregnancy

Sponsors & Collaborators

• SB Istanbul Education and Research Hospital: lead

Related Publications (1)

• Erickson M, Lawrence M, Lucado A. The role of diagnostic ultrasound in the examination of carpal tunnel syndrome: an update and systematic review. J Hand Ther. 2022 Apr-Jun;35(2):215-225. doi: 10.1016/j.jht.2021.04.014. Epub 2021 Apr 14.

  PMID: 34261588 BACKGROUND

MeSH Terms

Conditions

Carpal Tunnel Syndrome; Median Neuropathy

Interventions

Ultrasonography, Doppler

Condition Hierarchy (Ancestors)

Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Nerve Compression Syndromes; Cumulative Trauma Disorders; Sprains and Strains; Wounds and Injuries

Intervention Hierarchy (Ancestors)

Ultrasonography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: February 19, 2026
• First Posted: February 25, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): January 1, 2027
• Last Updated: April 9, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share