Fluid Balance in Acute Kidney Injury in Critically Ill Patients

NCT07338734 | Not Yet Recruiting

• 1 other identifier: Fluid Balance in AKI
• Study Type: observational
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective observational cohort study evaluates if fluid balance in the first 48 hours of ICU admission is linked to acute kidney injury (AKI) in critically ill adults. Patients without AKI at entry will have fluids tracked hourly via charts, weights, and labs to assess AKI risk by KDIGO criteria within 7 days. Findings may guide better fluid management to lower AKI rates.

Conditions

Fluid Balance; Acute Kidney Injury; Critically Ill; Critically Ill Acute Kidney Injury

Keywords

Fluid Balance; acute kidney injury; AKI; critically ill; KDIGO criteria

Outcome Measures

Primary Outcomes (1)

• Incidence of Acute Kidney Injury (AKI)

  Development of AKI defined by KDIGO criteria (increase in serum creatinine by ≥0.3 mg/dL within 48 hours or ≥1.5 times baseline within 7 days, or urine output \<0.5 mL/kg/h for 6 hours).

  Within 7 days after ICU admission

Secondary Outcomes (1)

• AKI Stage by KDIGO Criteria

  Within 7 days after ICU admission

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients aged 18 years or older admitted to the intensive care unit (ICU) at Assiut University Hospital without acute kidney injury (AKI) at admission. Eligible cases include prerenal, renal, postrenal AKI with hypovolemia; postoperative; CKD up to stage IIIb; compensated heart failure needing fluids.

You may qualify if:

• Adults aged 18 years or older admitted to the ICU.
• Patients with no AKI at ICU admission.
• AKI secondary to (prerenal cause-renal and post renal with manifestation of hypovolemia)-postoperative settings-On top of CKD up to Stage 111b-Compansated heart failure with indication of fluid therapy

You may not qualify if:

• Patients with pre-existing end-stage renal disease requiring dialysis.
• Patients with known chronic kidney disease stage 4 or higher.
• ICU readmissions during the same hospitalization.
• Patients who received renal replacement therapy before ICU admission
• Patients with AKI with manifestation of over load as pulmonary edema- pulmonary embolism-Acute decompensated heart failure

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Acute Kidney Injury; Critical Illness

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident at Internal Medicine Department, Assiut University

Study Record Dates

• First Submitted: January 4, 2026
• First Posted: January 14, 2026
• Study Start: January 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: January 14, 2026

Record last verified: 2026-01