Is There Any Prognostic Value of Serum Uromodulin in Sepsis Induced AKI.

NCT07295392 | Not Yet Recruiting

• 1 other identifier: Uromodulin in AKI
• Study Type: observational
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

To determine whether baseline (day 0; day of diagnosis),day 7 and on discharge serum uromodulin levels help predict clinical outcomes in adult patients with sepsis induced AKI.

Conditions

Acute Kidney Injury

Keywords

Serum uromodulin

Outcome Measures

Primary Outcomes (1)

• Serum Uromodulin as a Predictor of Acute Kidney Injury Outcome in Septic Patients

  To assess whether serum uromodulin levels measured at ICU admission (day 0), day 7, and at ICU discharge can predict AKI outcome (complete renal recovery versus progression to chronic kidney disease), length of ICU stay, and 30-day all-cause mortality in adult patients with sepsis-induced acute kidney injury.

  30 days

Secondary Outcomes (1)

• 2.1.Correlation Between Serum Uromodulin Levels and Need for Renal Replacement Therapy. 2.2.Correlation Between Serum Uromodulin Levels and SOFA Score. 2.3.Correlation Between Serum Uromodulin Levels and AKI Severity.

  From ICU admission to ICU discharge.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

People who is recently diagnosed with AKI due to sepsis meeting the previously mentioned criteria and doesn't have the exclusion criteria.

You may qualify if:

• Age ≥ 18 years
• Septic patients with AKI: Diagnosis of sepsis is based on combination of variables including Sepsis-3 criteria within 24 hours of ICU admission(suspected or confirmed infection on clinical , lab and imaging evidence , acute increase in SOFA score =\>2 points( or presence of septic shock). The latter is defined by a vasopressor requirement to maintain a mean arterial pressure of 65 mm Hg or greater and serum lactate level greater than 2 mmol/L (\>18 mg/dL) in the absence of hypovolemia (Singer et al 2016).
• Diagnosis of AKI according to KDIGO-criteria ( increase creatinine by =\>0.3 mg/dl ( =\>26.5 micmol/l ) within 48 hrs or increase cr =\>1.5 × baseline within 7days or urine output \< 0.5 ml / kg / hr for =\> 6hrs)
• Informed consent obtained and in case patient is unable to sign the consent his next of kin or has power

You may not qualify if:

• Patients diagnosed with ESRD or kidney transplantation
• Other causes of AKI
• Pregnancy related causes of AKI
• Active immunosuppressive therapy (e.g., high-dose steroids, chemotherapy)
• Patients with background of adult polycystic kidney disease
• Patients with cardiac failure
• Patients with solitary kidney because of small renal mass that could affect uromodulin level.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resistant doctor in internal medicine department at Assiut university

Study Record Dates

• First Submitted: December 8, 2025
• First Posted: December 19, 2025
• Study Start: March 10, 2026
• Primary Completion (Estimated): December 10, 2026
• Study Completion (Estimated): December 30, 2026
• Last Updated: December 31, 2025

Record last verified: 2025-12