Femoral Nerve Mobilization for Patients With Knee Osteoarthritis

NCT07329205 | Not Yet Recruiting

• 1 other identifier: RHPT/025/015
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Knee osteoarthritis (KO) is considered as a cause of disability among the elderly, causing pain, reduced quality of life, and decreased functionality. There is a limited knowledge about using femoral nerve mobilization in treating patients with arthritic changes. Objectives: This study will be designed to determine the efficacy of adding of femoral nerve mobilization on pain intensity, function, quality of life and central sensitization in patients with knee osteoarthritis Methods: Thirty patients (aged ≥50 years with KO Kellgren-Lawrence grades I-II) will be included in this study: Patients will randomly be assigned into two groups: group A will receive traditional physical therapy while group B will receive femoral nerve mobilization in addition to traditional physical therapy. Three sessions will be performed for four weeks by 3 session /week. Patients will be evaluated for pain intensity using the numerical rating scale (NRS), knee function by WOMAC scale, quality of life by 12-item Short Form Survey questionnaire (SF-12) and central sensitization by the Arabic version of central sensitization inventory (CSI).

Conditions

Knee Osteoarthristis

Keywords

NEURAL MOBILIZATION; Knee osteoarthritis; conventional physical therapy

Outcome Measures

Primary Outcomes (2)

• pain intensity

  The pain was assessed by the numerical rating scale (NRS) where zero indicating no pain and 10 indicating maximal pain

  after 4 weeks

• central sensitization

  The CSI is a validated questionnaire designed to identify symptoms associated with central sensitization. It has two components: Scale A assesses 25 common symptoms in individuals with central sensitization, resulting in a score ranging from 0 to 100. This score was interpreted as follows: subclinical (0-29), mild (30-39), moderate (40-49), severe (50-59), and extreme (60-100). Scale B, which is not scored, collects information on previous diagnoses of specific diseases

  after 4 weeks

Study Arms (2)

Control group

ACTIVE COMPARATOR

Traditional physical therapy

Other: traditional physical therapy

Neural mobilization group

EXPERIMENTAL

traditional physical therapy plus femoral nerve mobilization

Other: traditional physical therapy; Other: Femoral nerve mobilization

Interventions

traditional physical therapy OTHER

stretching exercises for hamstring, calf muscles and iliotibial band in addition to isotonic exercise for hip extensors and abductors and isometric quadriceps exercise

Control group; Neural mobilization group

Femoral nerve mobilization OTHER

A physiotherapist guided the patients in performing active mobilization of the femoral nerve. The prescribed method for active neural mobilization involved assuming a prone position supported by the forearms with a slight extension of the spine, flexion of the knee, and extension of the cervical spine. This was followed by performing the opposite movement

Neural mobilization group

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients aged 50 years or older, diagnosed with KO according to theAmerican College of Rheumatology's criteria with knee pain, and grade I or II on the Kellgren-Lawrence radiographic scale

You may not qualify if:

• individuals suffering from chronic conditions considered to be perpetuating factors (e.g., fibromyalgia)
• those with conditions causing lower extremity pain
• individuals who had taken analgesics within 24 h before evaluations
• those who had undergone corticosteroid or local anesthetic infiltration in the year prior to the study or during the follow-up period
• those using substances that could interfere with treatment
• those with a previous diagnosis of neuropathy (lumbosacral plexus) or myopathy
• those with contraindications to mobilization or exercise, and those with cognitive deficits (dementia, Alzheimer's).

Sponsors & Collaborators

• Prince Sattam Bin Abdulaziz University: lead

Study Sites (1)

Prince Sattam bin Abdulaziz University

Al Kharj, 16242, Saudi Arabia

Location

Related Publications (3)

• Pedersini P, Valdes K, Cantero-Tellez R, Cleland JA, Bishop MD, Villafane JH. Effects of Neurodynamic Mobilizations on Pain Hypersensitivity in Patients With Hand Osteoarthritis Compared to Robotic Assisted Mobilization: A Randomized Controlled Trial. Arthritis Care Res (Hoboken). 2021 Feb;73(2):232-239. doi: 10.1002/acr.24103. Epub 2021 Jan 3.

  PMID: 31675184 RESULT

• Serrano-Garcia B, Martinez-Cepa CB, Forriol F, Zuil-Escobar JC. Active Neurodynamic Technique at Home in Patients with Knee Osteoarthritis: An Open Single Arm Clinical Trial. Medicina (Kaunas). 2024 Nov 12;60(11):1857. doi: 10.3390/medicina60111857.

  PMID: 39597042 RESULT

• Serrano-Garcia B, Forriol-Campos F, Zuil-Escobar JC. Active Neurodynamics at Home in Patients with Knee Osteoarthritis: A Feasibility Study. J Clin Med. 2023 Oct 20;12(20):6635. doi: 10.3390/jcm12206635.

  PMID: 37892772 RESULT

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Central Study Contacts

Mohammed Hegazy, Phd

CONTACT

00966566169893; mohamed.mostafa@pt.cu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assisstant professor , department of health and rehabilitation sciences, college of applied medical siences

Study Record Dates

• First Submitted: December 15, 2025
• First Posted: January 9, 2026
• Study Start: December 20, 2025
• Primary Completion: February 10, 2026
• Study Completion: February 25, 2026
• Last Updated: January 9, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

SA (1)