Effects of Whole-Body Vibration in Patients with Knee Osteoarthritis.

NCT06662682 | Completed

• 1 other identifier: RadioSurg1
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Knee osteoarthritis is a chronic joint disease with an impact on quality of life and an increasing incidence what leads to huge costs and burden on the economy. The present study investigates immediate effects of whole-body vibration on pain, neuromuscular performance, and gait quality in patients with knee osteoarthritis. Eligible patients (n=20) with knee osteoarthritis grade 2 or 3 on Kallgren Lawrence will complete a 5 minute WBV training and a control condition in a randomized order (cross over design). Pain, maximum strength of the leg flexors and extensors, the chair rise test and gait parameters will be measured directly before and after the intervention/control.

Conditions

Knee Osteoarthristis

Keywords

Knee OA; whole-body vibration; pain; physical function; gait parameters

Outcome Measures

Primary Outcomes (1)

• Changes in pain of the osteo-arthrotic knee

  Changes in pain of the osteo-arthrotic knee during the treadmill test as determined on a visual analogue scale (VAS 0-10).

  Changes in pain of the osteoarthrotic knee during the treadmill test as determined on a visual analogue scale (VAS 0-10) before and after 5 min of intervention

Secondary Outcomes (12)

• Changes in isometric maximum leg flexion strength of the osteoarthritis knee

  Changes in isometric maximum leg flexion strength of the osteoarthritis knee before and after 5 min of Intervention.

• Changes in isometric maximum leg extension strength of the osteoarthritis knee

  Changes in isometric maximum leg extension strength of the osteoarthritis knee before and after 5 min of Intervention

• Changes of number of repetitions in the 30 s sit to stand (chair rise) test

  Changes in number of repetitions in the 30 s sit-to-stand test before and after 5 min of intervention

• Changes of ipsilateral stride length

  Changes of ipsilateral stride length (cm) at treadmill as determined by the 4D motion high-performance lab ( (Firma Diers Formetric, Germany) before and after 5 min of Intervention

• Changes of ipsilateral stride time

  Changes of ipsilateral stride length (cm) at treadmill as determined by the 4D motion high-performance lab (Firma Diers Formetric, Germany) before and after 5 min of intervention.

Study Arms (2)

Whole-Body Vibration

EXPERIMENTAL

The intervention (IC) will be specified as a five-minute Whole-Body Vibration session.

Other: Whole-Body Vibration

Control Condition

OTHER

The control condition (CC) will conduct the same protocol as the intervention condition. The only difference will be that the vibration plate will be switched off.

Other: Control Condition

Interventions

Whole-Body Vibration OTHER

The intervention (IC) will be specified as a five-minute Whole-Body Vibration session. The WBV take place on a side alternating vibration plate (Wellengang, Germany). The patients stand barefoot on the vibration plate on a prescribed position. In this position the amplitude will be 6-7mm. The WBV protocol contains mobilizing sequences with lower frequencies and activating sequences with higher frequencies

Whole-Body Vibration

Control Condition OTHER

Non-intervention control condition

Control Condition

Eligibility Criteria

• Age: 40 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• x-ray confirmed knee osteoarthritis (Kallgren-Lawrence 2-3)
• knee pain (NRS 0-10 \>2) for 3 months and at least 50% of the last 30 days

You may not qualify if:

• contraindications for WBV (acute injuries of the musculoskeletal system, new joint endoprosthesis, pregnancy, acute thrombosis, Epilepsia, cholecystolithiasis, nephrolithiasis, heart pace maker),
• other pathologies affecting gait or neuromuscular performance (rheumatic
• opioid medications, cortisol medications and intraarticular injections in the knee during the ist 3 months.

Sponsors & Collaborators

• University of Erlangen-Nürnberg Medical School: lead

Study Sites (1)

Oniversity Hospital Erlangen

Erlangen, Bavaria, 91054, Germany

Location

Related Publications (1)

• von Stengel S, Kemmler W, Engelke K, Kalender WA. Effect of whole-body vibration on neuromuscular performance and body composition for females 65 years and older: a randomized-controlled trial. Scand J Med Sci Sports. 2012 Feb;22(1):119-27. doi: 10.1111/j.1600-0838.2010.01126.x. Epub 2010 May 24.

  PMID: 20500555 BACKGROUND

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Marcel Betsch, MD

  University Hospital Erlangen, Germany

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Outcome assessor were unaware of participants status and were not allowed to ask correpondingly
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Research

Study Record Dates

• First Submitted: October 18, 2024
• First Posted: October 29, 2024
• Study Start: July 15, 2024
• Primary Completion: January 15, 2025
• Study Completion: January 16, 2025
• Last Updated: February 3, 2025

Record last verified: 2025-01

Locations

DE (1)