Effects of Preoperative Whey Protein and Exercise Support on Recovery After Total Hip Arthroplasty

NCT07329010 | Completed

• 1 other identifier: 010203
• Study Type: interventional
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: The aim of this project is to evaluate the effects of preoperative whey protein supplementation and a physical exercise program on postoperative recovery outcomes in patients undergoing total hip arthroplasty (THA). Specifically, inflammatory markers (CRP), nutritional status (albumin), mobilization time, length of hospital stay, and physical and social functioning will be assessed. As one of the first randomized controlled trials in Turkey to focus on the preoperative period and to evaluate a combined nutrition and exercise intervention in elderly surgical patients, this study holds pioneering significance in both clinical and academic contexts. Methods: This study is designed as a randomized controlled trial. The intervention group will receive whey protein supplementation and a home-based exercise program for 14 days preoperatively, while the control group will receive standard preoperative care. Data collection will be performed preoperatively and on postoperative days 3 and 5, focusing on metabolic and functional parameters. Expected Outcomes: The findings of this study are expected to contribute to the improvement of patient care through a multidisciplinary approach, inform health policy development, and provide a foundation for larger-scale clinical research in Turkey.

Conditions

Arthoplasty; Nutrition; Exercise Training; Preoperative; Geriatric Assessment

Keywords

Whey Protein; Exercise; Preoperative Nutrition; Total Hip Arthroplasty (THA); Elderly Patients; Postoperative Recovery; Functional Outcomes

Outcome Measures

Primary Outcomes (2)

• Serum Albumin Level

  Postoperative serum albumin levels measured on days 3 and 5 after total hip arthroplasty.

  5 days

• C-Reactive Protein (CRP) Level

  Postoperative serum CRP levels measured on days 3 and 5 after total hip arthroplasty.

  5 days

Secondary Outcomes (3)

• Time to Mobilization

  5 days

• Length of Hospital Stay

  5 days

• Physical and Social Functioning

  5 days

Study Arms (2)

Intervention Group: "Preoperative Whey Protein Supplementation and Exercise Program

EXPERIMENTAL

The preoperative exercise and protein supplementation program will be conducted by patients in their home environment. Patients will be enrolled in the study 14 days prior to the scheduled surgery. At the start of the program, all patients will receive face-to-face instructions, and data will be collected under the supervision of an experienced orthopedic surgeon at the hospital

Dietary Supplement: Preoperative Whey Protein and Exercise Program

Control Group: "Standard Preoperative Care"

NO INTERVENTION

Patients in the control group will receive only the hospital's standard preoperative care protocol. This care includes: Daily monitoring of vital signs Preoperative laboratory tests Anesthesia pre-assessment Surgical information and counseling Medication management No additional protein supplementation or exercise training will be provided specifically to this group.

Interventions

Preoperative Whey Protein and Exercise Program DIETARY_SUPPLEMENT

The intervention group will receive 14 days of preoperative whey protein supplementation combined with a home-based exercise program. Patients will receive face-to-face instructions at program initiation, and data will be collected under the supervision of an experienced orthopedic surgeon

Also known as: Dietary Supplement + Behavioral (Exercise)

Intervention Group: "Preoperative Whey Protein Supplementation and Exercise Program

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged between 50 and 70 years
• Scheduled for elective total hip arthroplasty (THA)
• Able to participate in the preoperative intervention for at least 2 weeks
• Conscious and able to communicate

You may not qualify if:

• Patients with advanced malnutrition
• Patients with active cancer, malabsorption, liver or kidney failure
• Patients with severe cognitive impairment
• Patients with health conditions that prevent participation in exercise

Sponsors & Collaborators

• TC Erciyes University: lead

Study Sites (1)

Erciyes unıversity

Kayseri, Talas, 38260, Turkey (Türkiye)

Location

Related Publications (1)

• Adebero T, Omana H, Somerville L, Lanting B, Hunter SW. Effectiveness of prehabilitation on outcomes following total knee and hip arthroplasty for osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Disabil Rehabil. 2024 Dec;46(24):5771-5790. doi: 10.1080/09638288.2024.2313128. Epub 2024 Feb 13.

  PMID: 38349251 RESULT

MeSH Terms

Conditions

Motor Activity

Interventions

Dietary Supplements; Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: This is an open-label study. Neither participants nor investigators are blinded to group assignments.
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Participants are randomly assigned to either the intervention group, which receives 14 days of preoperative whey protein supplementation combined with a home-based exercise program, or the control group, which receives standard preoperative care. Both groups are followed for metabolic and functional outcomes on postoperative days 3 and 5

Study Record Dates

• First Submitted: December 2, 2025
• First Posted: January 9, 2026
• Study Start: September 25, 2025
• Primary Completion: January 15, 2026
• Study Completion: April 30, 2026
• Last Updated: May 5, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)