Prevalence of Cerebral Large Vessel Occlusion Among Acute Ischemic Stroke Patients in Assiut University Hospitals

NCT07326410 | Not Yet Recruiting DMC

• 1 other identifier: Prevalence of Cerebral LVO
• Study Type: observational
• Target: 300
• Locations: 0 countries
• Sites: N/A

Brief Summary

Prevalence of Large Vessel Occlusion among acute ischemic stroke patients in Assiut University hospitals

• To describe clinical and radiological characteristics of LVO patients.
• To assess factors associated with LVO (age, sex, stroke severity, comorbidities).
• Study Design
• Type: single center, prospective observational cross-sectional study
• Duration: 12-month recruitment period
• Setting: Assiut university hospitals, stroke unit.
• Study Population
• Adults (≥18 years)
• Diagnosed with acute ischemic stroke within 24 hours of symptom onset
• Underwent vascular imaging (CTA or MRA) on admission Exclusion Criteria:
• Hemorrhagic stroke
• Stroke mimics
• Incomplete imaging data 4. Definitions Large Vessel Occlusion (LVO) defined as occlusion in:
• Intracranial ICA
• M1 or proximal M2 segments of MCA
• Basilar artery ± Optional: A1 6. Data Collection Clinical Data:
• Demographics (age, sex)
• Risk factors (HTN, DM, AF, CAD, smoking)
• NIHSS on admission and discharge mRS on admission and discharge
• Onset-to-door time
• Imaging modality used Imaging Data:
• Site of occlusion
• ASPECTS (optional)
• Collateral status (optional if available) Hospital Data:
• Facility type (public vs private)
• Door-to-CT and door-to-CTA times 8. Analysis Plan
• Primary: Prevalence of LVO = Number of LVO cases / Total AIS patients with vascular imaging
• Subgroup analysis: By age group, sex, region, NIHSS
• Secondary: Logistic regression to identify predictors of LVO

Conditions

Ischemic Stroke

Keywords

Prevalence of cerebral Large Vessel Occlusion among acute ischemic stroke patients

Outcome Measures

Primary Outcomes (1)

• To determine the prevalence of LVO among acute ischemic stroke (AIS) patients presenting to Assiut University hospitals

  Prevalence of LVO = Number of LVO cases / Total AIS patients with vascular imaging

  12 months

Secondary Outcomes (1)

• -To describe clinical and radiological characteristics of LVO patients. - To assess factors associated with LVO (age, sex, stroke severity, comorbidities).

  12 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Large Vessel Occlusion (LVO) defined as occlusion in: * Intracranial ICA * M1 or proximal M2 segments of MCA * Basilar artery ± Optional: A1 Clinical Data: * Demographics (age, sex) * Risk factors (HTN, DM, AF, CAD, smoking) * NIHSS on admission and discharge mRS on admission and discharge * Onset-to-door time * Imaging modality used Imaging Data: * Site of occlusion * ASPECTS (optional) * Collateral status (optional if available) Hospital Data: * Facility type (public vs private) * Door-to-CT and door-to-CTA times

You may qualify if:

• Adults (≥18 years)
• Diagnosed with acute ischemic stroke within 24 hours of symptom onset
• Underwent vascular imaging (CTA or MRA) on admission

You may not qualify if:

• Hemorrhagic stroke
• Stroke mimics
• Incomplete imaging data

Sponsors & Collaborators

• Assiut University: lead

Related Links

• Prevalence of cerebral Large Vessel Occlusion among acute ischemic stroke

MeSH Terms

Conditions

Ischemic Stroke

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Ahmed Nasr Professor of neurology, Professor

CONTACT

+201009949677; d_ahmednasr@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 2 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident of neurology

Study Record Dates

• First Submitted: December 8, 2025
• First Posted: January 8, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): March 1, 2027
• Last Updated: January 8, 2026

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share